{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:45:02Z","timestamp":1782888302176,"version":"3.54.5"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Coronary atherosclerotic heart disease is one of the most serious health and life-threatening diseases. There is no doubt that despite the increasing number of assessment methods used clinically, the prognosis assessment is still not ideal, and newer assessment methods are needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the predictive value of quantitative flow ratio (QFR) for adverse events (vessel-oriented composite endpoint events\/target lesion failure) in patients after percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Eight studies involving 4,173 patients (5,688 vascular lesions) were included. These are studies on the relationship between QFR values and prognosis of adverse cardiac events after PCI. This meta-analysis was performed after quality assessment and data extraction of clinical trials data that met the inclusion criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Each of the eight studies described the cut-off values for the best predictive ability of post-PCI QFR and the hazard ratio (HR) between QFR values and adverse events, respectively. The pooled HR of these studies was 4.72 (95% CI: 3.29\u20136.75). Concurrently, lower post-PCI QFR values were associated with the occurrence of individual clinical events (cardiac death\/myocardial infarction\/target vessel revascularization), with relative risk values of 6.51 (95% CI: 4.96\u20138.53), 4.83 (95% CI: 3.08\u20137.57), and 4.21 (95% CI: 2.66\u20136.68), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>QFR may have great potential in the assessment of prognosis. It is necessary to measure QFR value after PCI. A lower QFR value after PCI was an important predictor for experiencing adverse events.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2023.1164290","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T20:49:48Z","timestamp":1691441388000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Prognostic value of quantitative flow ratio in patients with coronary heart disease after percutaneous coronary intervention therapy: a meta-analysis"],"prefix":"10.3389","volume":"10","author":[{"given":"Huaigang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1161\/01.cir.0000035036.22612.2b","article-title":"World Heart Day 2002: the international burden of cardiovascular disease: responding to the emerging global epidemic","volume":"106","author":"Bonow","year":"2002","journal-title":"Circulation"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1056\/NEJMoa1505532","article-title":"Effect of PCI on long-term survival in patients with stable ischemic heart disease","volume":"373","author":"Sedlis","year":"2015","journal-title":"N Engl J Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1001\/jama.284.7.835","article-title":"The TIMI risk score for unstable angina\/non-ST elevation MI: a method for prognostication and therapeutic decision making","volume":"284","author":"Antman","year":"2000","journal-title":"JAMA"},{"key":"B4","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1093\/ejcts\/ezs043","article-title":"EuroSCORE II","volume":"41","author":"Nashef","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2541","DOI":"10.1093\/eurheartj\/ehu278","article-title":"2014 ESC\/EACTS guidelines on myocardial revascularization: the task force on myocardial revascularization of the European society of cardiology (ESC) and the European association for cardio-thoracic surgery (EACTS) developed with the special contribution of the European association of percutaneous cardiovascular interventions (EAPCI)","volume":"37","author":"Windecker","year":"2014","journal-title":"Eur Heart J"},{"key":"B6","first-page":"219","article-title":"The SYNTAX score: an angiographic tool grading the complexity of coronary artery disease","volume":"2","author":"Sianos","year":"2005","journal-title":"EuroIntervention"},{"key":"B7","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/S0140-6736(13)60108-7","article-title":"Anatomical and clinical characteristics to guide decision making between coronary artery bypass surgery and percutaneous coronary intervention for individual patients: development and validation of SYNTAX score II","volume":"9867","author":"Farooq","year":"2013","journal-title":"Lancet"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.4244\/EIJY19M01_01","article-title":"2018 ESC\/EACTS guidelines on myocardial revascularization","volume":"14","author":"Neumann","year":"2019","journal-title":"EuroIntervention"},{"key":"B9","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1093\/ehjqcco\/qcac053","article-title":"Predictive value of post-percutaneous coronary intervention fractional flow reserve: a systematic review and meta-analysis","volume":"9","author":"Andersen","year":"2023","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e2232842","DOI":"10.1001\/jamanetworkopen","article-title":"Prognostic implications of fractional flow reserve after coronary stenting: a systematic review and meta-analysis","volume":"5","author":"Hwang","year":"2022","journal-title":"JAMA Netw Open"},{"key":"B11","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1093\/eurheartj\/ehz918","article-title":"Fractional flow reserve in clinical practice: from wire-based invasive measurement to image-based computation","volume":"41","author":"Tu","year":"2020","journal-title":"Eur Heart J"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1016\/j.jcin.2016.07.013","article-title":"Diagnostic accuracy of fast computational approaches to drive fractional flow reserve from diagnostic coronary angiography: the international multicenter FAVOR pilot study","volume":"9","author":"Tu","year":"2016","journal-title":"JACC Cardiovasc Interv"},{"key":"B13","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1002\/ccd.28283","article-title":"Diagnostic performance of quantitative flow ratio in prospectively enrolled patients: an individual patient-data meta-analysis","volume":"94","author":"Westra","year":"2019","journal-title":"Catheter Cardiovasc Interv"},{"key":"B14","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1097\/MCA.0000000000000650","article-title":"Quantitative flow ratio and instantaneous wave-free ratio for the assessment of the functional severity of intermediate coronary artery stenosis","volume":"29","author":"Emori","year":"2018","journal-title":"Coron Artery Dis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1016\/j.jcin.2019.06.003","article-title":"Prognostic value of QFR measured immediately after successful stent implantation: the international multicenter prospective HAWKEYE study","volume":"12","author":"Biscaglia","year":"2019","journal-title":"JACC Cardiovasc Interv"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1016\/j.jcin.2019.08.009","article-title":"Clinical implication of quantitative flow ratio after percutaneous coronary intervention for 3-vessel disease","volume":"12","author":"Kogame","year":"2019","journal-title":"JACC Cardiovasc Interv"},{"key":"B17","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1007\/s10554-020-02068-0","article-title":"Clinical implication of QFR in patients with ST-segment elevation myocardial infarction after drug-eluting stent implantation","volume":"37","author":"Tang","year":"2021","journal-title":"Int J Cardiovasc Imaging"},{"key":"B18","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1002\/clc.23630","article-title":"Clinical implication of quantitative flow ratio to predict clinical events after drug-coated balloon angioplasty in patients with in-stent restenosis","volume":"44","author":"Tang","year":"2021","journal-title":"Clin Cardiol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e19052","DOI":"10.1161\/JAHA.120.019052","article-title":"Quantitative flow ratio to predict nontarget vessel-related events at 5 years in patients with ST-segment-elevation myocardial infarction undergoing angiography-guided revascularization","volume":"10","author":"Bar","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"B20","doi-asserted-by":"publisher","first-page":"167","DOI":"10.5603\/CJ.a2021.0154","article-title":"Prognostic value of post-procedural uQFR for drug-coated balloons in the treatment of in-stent restenosis","volume":"30","author":"Liu","year":"2021","journal-title":"Cardiol J"},{"key":"B21","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1002\/clc.23816","article-title":"Post-PCI quantitative flow ratio predicts 3-year outcome after rotational atherectomy in patients with heavily calcified lesions","volume":"45","author":"You","year":"2022","journal-title":"Clin Cardiol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"109839","DOI":"10.1016\/j.diabres.2022.109839","article-title":"Effects of diabetes mellitus on post-intervention coronary physiological assessment derived by quantitative flow ratio in patients with coronary artery disease underwent percutaneous coronary intervention","volume":"186","author":"Zhang","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: is blinding necessary?","volume":"17","author":"Jadad","year":"1996","journal-title":"Control Clin Trials"},{"key":"B24","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur J Epidemiol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1016\/S0140-6736(21)02248-0","article-title":"Angiographic quantitative flow ratio-guided coronary intervention (FAVOR III China): a multicentre, randomised, sham-controlled trial","volume":"398","author":"Xu","year":"2021","journal-title":"Lancet"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1016\/j.jcin.2019.05.054","article-title":"Blinded physiological assessment of residual ischemia after successful angiographic percutaneous coronary intervention: the DEFINE PCI study","volume":"12","author":"Jeremias","year":"2019","journal-title":"JACC Cardiovasc Interv"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.jcin.2016.01.046","article-title":"Utilizing post-intervention fractional flow reserve to optimize acute results and the relationship to long-term outcomes","volume":"9","author":"Agarwal","year":"2016","journal-title":"JACC Cardiovasc Interv"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1016\/j.jcin.2019.05.054","article-title":"Blinded physiological assessment of residual ischemia after successful angiographic percutaneous coronary intervention: the DEFINE PCI study","volume":"12","author":"Jeremias","year":"2019","journal-title":"J Am Coll Cardiol Interv"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e007428","DOI":"10.1161\/CIRCINTERVENTIONS.118.007428","article-title":"Routine fractional flow reserve measurement after percutaneous coronary intervention: the FFR-SEARCH study","volume":"12","author":"Van-Bommel","year":"2019","journal-title":"Circ Cardiovasc Interv"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1161\/01.cir.99.8.1015","article-title":"Comparison of quantitative coronary angiography, intravascular ultrasound, and coronary pressure measurement to assess optimum stent deployment","volume":"99","author":"Hanekamp","year":"1999","journal-title":"Circulation"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1161\/hc4101.097539","article-title":"Fractional flow reserve compared with intravascular ultrasound guidance for optimizing stent deployment","volume":"104","author":"Fearon","year":"2001","journal-title":"Circulation"},{"key":"B32","first-page":"222","article-title":"Correlation between OCT-derived intrastent dimensions and fractional flow reserve measurements after coronary stent implantation and impact on clinical outcome","volume":"27","author":"Reith","year":"2015","journal-title":"J Invasive Cardiol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s10554-017-1262-4","article-title":"In-stent fractional flow reserve variations and related optical coherence tomography findings: the FFR\u2013OCT co-registration study","volume":"34","author":"Pyxaras","year":"2018","journal-title":"Int J Cardiovasc Imaging"},{"key":"B34","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ijcard.2015.03.043","article-title":"Assessment of stent edge dissections by fractional flow reserve","volume":"185","author":"Chung","year":"2015","journal-title":"Int J Cardiol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.ijcard.2016.11.005","article-title":"Assessment of the hemodynamic characteristics of absorb BVS in a porcine coronary artery model","volume":"227","author":"Tenekecioglu","year":"2017","journal-title":"Int J Cardiol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1002\/ccd.30681","article-title":"Quantitative flow ratio modulated by intracoronary optical coherence tomography for predicting physiological efficacy of percutaneous coronary intervention","volume":"102","author":"Ding","year":"2023","journal-title":"Catheter Cardiovasc Interv"},{"key":"B37","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.rec.2021.04.008","article-title":"Quantitative flow ratio for evaluation of borderline coronary lesions in patients with severe aortic stenosis","volume":"75","author":"Kleczynski","year":"2022","journal-title":"Rev Esp Cardiol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"118","DOI":"10.5114\/aic.2022.118527","article-title":"Comparison of FFR, iFR, and QFR assessment in patients with severe aortic stenosis and coronary heart disease","volume":"18","author":"Zasada","year":"2022","journal-title":"Postepy Kardiol Interwencyjnej"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1002\/ccd.29592","article-title":"Diagnostic accuracy of quantitative flow ratio for assessment of coronary stenosis significance from a single angiographic view: a novel method based on bifurcation fractal law","volume":"97","author":"Tu","year":"2021","journal-title":"Catheter Cardiovasc Interv"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2023.1164290\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T20:49:52Z","timestamp":1691441392000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2023.1164290\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,7]]},"references-count":39,"alternative-id":["10.3389\/fcvm.2023.1164290"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2023.1164290","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,7]]},"article-number":"1164290"}}