{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T16:06:20Z","timestamp":1772121980543,"version":"3.50.1"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Corin is a protease in the natriuretic peptide system. Deleterious <jats:italic>CORIN<\/jats:italic> variants are associated with hypertension and heart disease. It remains unclear if and to what extent corin deficiency may contribute to heart failure (HF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>Corin<\/jats:italic> knockout (KO) mice were used as a model. Cardiac function was assessed by echocardiography and tissue analysis in <jats:italic>Corin<\/jats:italic> KO mice at different ages or subjected to transverse aortic constriction (TAC), which increased pressure overload. Heart and lung tissues were analyzed for cardiac hypertrophy and lung edema using wheat germ agglutinin, Sirius red, Masson's trichrome, and Prussian blue staining. Recombinant corin was tested for its effect on cardiac function in the TAC-operated <jats:italic>Corin<\/jats:italic> KO mice. Selected gene expression in the heart was examined by RT-PCR. ELISA was used to analyze factors in plasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Corin<\/jats:italic> KO mice had progressive cardiac dysfunction with cardiac hypertrophy and fibrosis after 9 months of age, likely due to chronic hypertension. When <jats:italic>Corin<\/jats:italic> KO mice were subjected to TAC at 10\u201312 weeks of age, cardiac function decreased more rapidly than in similarly treated wild-type mice. When the TAC-operated <jats:italic>Corin<\/jats:italic> KO mice were treated with recombinant corin protein, cardiac dysfunction, hypertrophy, and fibrosis were ameliorated. The corin treatment also decreased the gene expression associated with cardiac hypertrophy and fibrosis, increased plasma cGMP levels, lowered plasma levels of N-terminal pro-atrial natriuretic peptide, angiotensin II, and aldosterone, and lessened lung edema in the <jats:italic>Corin<\/jats:italic> KO mice subjected to TAC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Corin deficiency impairs cardiac function and exacerbates HF development in mice. Corin protein may be used to reduce cardiac hypertrophy and fibrosis, suppress the renin-angiotensin-aldosterone system, and improve cardiac function in HF.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2023.1164524","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T16:05:18Z","timestamp":1691769918000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Corin deficiency impairs cardiac function in mouse models of heart 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