{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:48:56Z","timestamp":1769834936016,"version":"3.49.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>HIV-associated lipodystrophy (HIVLD) is a metabolic condition with an irregularity in the production of lipoprotein particles, and its occurrence varies among HIV-infected patients. <jats:italic>MTP<\/jats:italic> and <jats:italic>ABCG2<\/jats:italic> genes have a role in the transport of lipoproteins. The polymorphisms of <jats:italic>MTP<\/jats:italic> -493G\/T and <jats:italic>ABCG2<\/jats:italic> 34G\/A affect its expression and influence the secretion and transportation of lipoproteins. Hence, we investigated the <jats:italic>MTP -<\/jats:italic>493G\/T and <jats:italic>ABCG2<\/jats:italic> 34G\/A polymorphisms in 187 HIV-infected patients (64 with HIVLD and 123 without HIVLD) along with 139 healthy controls using polymerase chain reaction (PCR)-restriction fragment length polymorphism and expression analysis using real-time PCR. <jats:italic>ABCG2<\/jats:italic> 34A allele showed an insignificantly reduced risk of LDHIV severity [<jats:italic>P<\/jats:italic>\u2009=\u20090.07, odds ratio (OR)\u2009=\u20090.55]. <jats:italic>MTP<\/jats:italic> -493T allele exhibited a non-significantly reduced risk for the development of dyslipidemia (<jats:italic>P<\/jats:italic>\u2009=\u20090.08, OR\u2009=\u20090.71). In patients with HIVLD<jats:italic>, the ABCG2<\/jats:italic> 34GA genotype was linked with impaired low-density lipoprotein levels and showed a reduced risk for LDHIV severity (<jats:italic>P<\/jats:italic>\u2009=\u20090.04, OR\u2009=\u20090.17). In patients without HIVLD, <jats:italic>the ABCG2<\/jats:italic> 34GA genotype was associated with impaired triglyceride levels with marginal significance and showed an increased risk for the development of dyslipidemia (<jats:italic>P<\/jats:italic>\u2009=\u20090.07, OR\u2009=\u20092.76). The expression level of <jats:italic>MTP<\/jats:italic> gene was 1.22-fold decreased in patients without HIVLD compared with that in patients with HIVLD. <jats:italic>ABCG2<\/jats:italic> gene was upregulated 2.16-fold in patients with HIVLD than in patients without HIVLD. In conclusion, <jats:italic>MTP<\/jats:italic> -493C\/T polymorphism influences the expression level of <jats:italic>MTP<\/jats:italic> in patients without HIVLD. Individuals without HIVLD having <jats:italic>ABCG2<\/jats:italic> 34GA genotype with impaired triglyceride levels may facilitate dyslipidemia risk.<\/jats:p>","DOI":"10.3389\/fcvm.2023.1177054","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T09:27:47Z","timestamp":1685438867000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative analysis of MTP -493G\/T and ABCG2 34G\/A polymorphisms and theirs expression in HIV-associated lipodystrophy 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