{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:29:23Z","timestamp":1779103763310,"version":"3.51.4"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Adenovirus (AdV) has been suggested to be involved in pathogenesis of atrial fibrillation (AF). We aimed to evaluate an association between AdV-specific immunoglobulins G in the serum (AdV-IgG) and AF. The present case-control study comprised two cohorts, including cohort 1 of patients with AF and cohort 2 of asymptomatic subjects. Initially, two groups, MA and MB, were selected from the cohorts 1 and 2, respectively, for serum proteome profiling using an antibody microarray to identify possible relevant protein targets. The data of microarray analysis indicated a possible overall increase in the total adenovirus signals in the group MA vs. group MB, suggesting potential relevance of adenoviral infection to AF. Then, the groups A (with AF) and B (control) were selected from the cohorts 1 and 2, respectively, to assay the presence and levels of AdV-IgG- by ELSA. The prevalence of AdV-IgG-positive status demonstrated a 2-fold increase in the group A (AF) compared with that in the group B (asymptomatic subjects); odds ratio 2.06 (95%CI: 1.11\u20133.84; <jats:italic>P<\/jats:italic>\u2009=\u20090.02). The prevalence of obesity demonstrated an approximately 3-fold increase in AdV-IgG-positive patients of the group A compared with that in AdV-IgG-negative patients of the same group A (odds ratio 2.7; 95% CI: 1.02\u20137.1; <jats:italic>P<\/jats:italic>\u2009=\u20090.04). Thus, AdV-IgG-positive reactivity was independently associated with AF, and AF was independently associated with BMI, indicating that adenoviral infection may be a possible etiological factor for AF.<\/jats:p>","DOI":"10.3389\/fcvm.2023.1190051","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T05:46:30Z","timestamp":1684907190000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Associations of adenovirus-reactive immunoglobulins with atrial fibrillation and body mass index"],"prefix":"10.3389","volume":"10","author":[{"given":"Nadezhda G.","family":"Gumanova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polina D.","family":"Zlobina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalya L.","family":"Bogdanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakob A.","family":"Brutyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena N.","family":"Kalemberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria A.","family":"Metelskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karapet V.","family":"Davtyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana M.","family":"Drapkina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.ymthe.2005.05.008","article-title":"The influence of adenovirus fiber structure and function on vector development for gene therapy","volume":"12","author":"Nicklin","year":"2005","journal-title":"Mol Ther"},{"key":"B2","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/B978-0-323-35761-6.00010-9","article-title":"Adenovirus vaccines","author":"Gray","year":"2018","journal-title":"Plotkin\u2019s Vaccines"},{"key":"B3","doi-asserted-by":"publisher","first-page":"9694","DOI":"10.1096\/fj.202000667R","article-title":"Adenovirus targets transcriptional and posttranslational mechanisms to limit gap junction function","volume":"34","author":"Calhoun","year":"2020","journal-title":"FASEB J"},{"key":"B4","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1093\/europace\/eut395","article-title":"The European heart rhythm association symptom classification for atrial fibrillation: validation and improvement through a simple modification","volume":"16","author":"Wynn","year":"2014","journal-title":"Europace"},{"key":"B5","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1186\/s12872-021-02300-2","article-title":"The predictive role of early recurrences of atrial arrhythmias after pulmonary vein cryoballoon ablation. Is blanking period an outdated concept? Insights from 12-month continuous cardiac monitoring","volume":"21","author":"Davtyan","year":"2021","journal-title":"BMC Cardiovasc Disord"},{"key":"B6","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1093\/eurheartj\/ehaa612","article-title":"(2020) ESC guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European association for cardio-thoracic surgery (EACTS): the task force for the diagnosis and management of atrial fibrillation of the European society of cardiology (ESC) developed with the special contribution of the European heart rhythm association (EHRA) of the ESC","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur Heart J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e12454","DOI":"10.1111\/micc.12454","article-title":"Increase in perfused boundary region of endothelial glycocalyx is associated with higher prevalence of ischemic heart disease and lesions of microcirculation and vascular wall","volume":"25","author":"Gorshkov","year":"2018","journal-title":"Microcirculation"},{"key":"B8","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.bbrc.2017.03.136","article-title":"Direct labeling of serum proteins by fluorescent dye for antibody microarray","volume":"486","author":"Klimushina","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"B9","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.bbrc.2022.09.053","article-title":"Application of an antibody microarray for serum protein profiling of coronary artery stenosis","volume":"631","author":"Gumanova","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"key":"B10","first-page":"337","article-title":"Multianalyte microspot immunoassay. The microanalytical \u201ccompact disk\u201d of the future","volume":"50","author":"Ekins","year":"1992","journal-title":"Ann Biol Clin (Paris)"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1126\/science.1062191","article-title":"Global analysis of protein activities using proteome chips","volume":"293","author":"Zhu","year":"2001","journal-title":"Science"},{"key":"B12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/978-1-59745-372-1_5","article-title":"Antibody-based microarrays","volume":"509","author":"Wingren","year":"2009","journal-title":"Methods Mol Biol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/bs.acc.2015.01.002","article-title":"Antibody arrays in biomarker discovery","volume":"69","author":"Wilson","year":"2015","journal-title":"Adv Clin Chem"},{"key":"B14","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/pmic.201400261","article-title":"Array-based proteomic approaches to study signal transduction pathways: prospects, merits and challenges","volume":"15","author":"Gahoi","year":"2015","journal-title":"Proteomics"},{"key":"B15","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00430-019-00645-2","article-title":"Human adenovirus binding to host cell receptors: a structural view","volume":"209","author":"Stasiak","year":"2020","journal-title":"Med Microbiol Immunol"},{"key":"B16","first-page":"804","volume-title":"Adenoviruses. Principles of virology","author":"Flint","year":"2004"},{"key":"B17","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.jcv.2008.05.012","article-title":"A myocarditis outbreak with fatal cases associated with adenovirus subgenera C among children from Havana City in 2005","volume":"43","author":"Sav\u00f3n","year":"2008","journal-title":"J Clin Virol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/s0735-1097(03)00648-x","article-title":"Detection of viruses in myocardial tissues by polymerase chain reaction. Evidence of adenovirus as a common cause of myocarditis in children and adults","volume":"42","author":"Bowles","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1093\/eurheartj\/ehn296","article-title":"Acute viral myocarditis","volume":"29","author":"Dennert","year":"2008","journal-title":"Eur Heart J"},{"key":"B20","doi-asserted-by":"publisher","first-page":"12125","DOI":"10.1128\/JVI.79.19.12125-12131.2005","article-title":"Adenovirus receptors","volume":"79","author":"Zhang","year":"2005","journal-title":"J Virol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"880","DOI":"10.3109\/10715762.2011.571684","article-title":"New insights into how adenovirus might lead to obesity: an oxidative stress theory","volume":"45","author":"Waye","year":"2011","journal-title":"Free Radic Res"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e2255","DOI":"10.1002\/rmv.2255","article-title":"Association of adenovirus 36 infection and obesity; an updated meta-analysis of community-based studies","volume":"32","author":"Marjani","year":"2022","journal-title":"Rev Med Virol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"3719","DOI":"10.3390\/v7072787","article-title":"Adenovirus 36 and obesity: an overview","volume":"7","author":"Ponterio","year":"2015","journal-title":"Viruses"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1001\/jama.292.20.2471","article-title":"Obesity and the risk of new-onset atrial fibrillation","volume":"292","author":"Wang","year":"2004","journal-title":"JAMA"},{"key":"B25","doi-asserted-by":"publisher","first-page":"28","DOI":"10.15420\/aer.2018.76.2","article-title":"Obesity and atrial fibrillation: epidemiology, pathophysiology and novel therapeutic opportunities","volume":"8","author":"Vyas","year":"2019","journal-title":"Arrhythm Electrophysiol Rev"},{"key":"B26","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ahj.2015.11.016","article-title":"Body mass index and the risk of new-onset atrial fibrillation in middle-aged adults","volume":"173","author":"Berkovitch","year":"2016","journal-title":"Am Heart J"},{"key":"B27","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.ijcard.2017.03.103","article-title":"Atrial fibrillation risk in metabolically healthy obesity: a nationwide population-based study","volume":"240","author":"Lee","year":"2017","journal-title":"Int J Cardiol"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2023.1190051\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T05:46:35Z","timestamp":1684907195000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2023.1190051\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,24]]},"references-count":27,"alternative-id":["10.3389\/fcvm.2023.1190051"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2023.1190051","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,24]]},"article-number":"1190051"}}