{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:02:38Z","timestamp":1792202558176,"version":"4.4.0"},"reference-count":305,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000199","name":"United States Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["#2020-67001-30716"],"award-info":[{"award-number":["#2020-67001-30716"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007812","name":"University of Washington","doi-asserted-by":"publisher","award":["U01 AI22285"],"award-info":[{"award-number":["U01 AI22285"]}],"id":[{"id":"10.13039\/100007812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Serum amyloid A (SAA) subtypes 1\u20133 are well-described acute phase reactants that are elevated in acute inflammatory conditions such as infection, tissue injury, and trauma, while SAA4 is constitutively expressed. SAA subtypes also have been implicated as playing roles in chronic metabolic diseases including obesity, diabetes, and cardiovascular disease, and possibly in autoimmune diseases such as systemic lupus erythematosis, rheumatoid arthritis, and inflammatory bowel disease. Distinctions between the expression kinetics of SAA in acute inflammatory responses and chronic disease states suggest the potential for differentiating SAA functions. Although circulating SAA levels can rise up to 1,000-fold during an acute inflammatory event, elevations are more modest (\u223c5-fold) in chronic metabolic conditions. The majority of acute-phase SAA derives from the liver, while in chronic inflammatory conditions SAA also derives from adipose tissue, the intestine, and elsewhere. In this review, roles for SAA subtypes in chronic metabolic disease states are contrasted to current knowledge about acute phase SAA. Investigations show distinct differences between SAA expression and function in human and animal models of metabolic disease, as well as sexual dimorphism of SAA subtype responses.<\/jats:p>","DOI":"10.3389\/fcvm.2023.1197432","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T01:55:33Z","timestamp":1686794133000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":78,"title":["Serum amyloid A and metabolic disease: evidence for a critical role in chronic inflammatory conditions"],"prefix":"10.3389","volume":"10","author":[{"given":"Laura J.","family":"den Hartigh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolline S.","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Song","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Chait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Blaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1136\/adc.68.2.210","article-title":"Serum amyloid A protein in acute viral infections","volume":"68","author":"Miwata","year":"1993","journal-title":"Arch Dis Child"},{"key":"B2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1080\/00365540050165848","article-title":"C-reactive protein and serum amyloid A protein in neonatal infections","volume":"32","author":"Pizzini","year":"2000","journal-title":"Scand J Infect Dis"},{"key":"B3","first-page":"58","article-title":"Serum amyloid A in the assessment of early inflammatory arthritis","volume":"27","author":"Cunnane","year":"2000","journal-title":"J Rheumatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s002960050114","article-title":"Serum amyloid A--an indicator of inflammation in ankylosing spondylitis","volume":"19","author":"Lange","year":"2000","journal-title":"Rheumatol Int"},{"key":"B5","first-page":"890","article-title":"Activation of the cytokine network in familial Mediterranean fever","volume":"26","author":"Gang","year":"1999","journal-title":"J Rheumatol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/ar78","article-title":"Acute-phase serum amyloid A production by rheumatoid arthritis synovial tissue","volume":"2","author":"O\u2019Hara","year":"2000","journal-title":"Arthritis Res"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2801","DOI":"10.4049\/jimmunol.166.4.2801","article-title":"Serum amyloid A (apoSAA) expression is up-regulated in rheumatoid arthritis and induces transcription of matrix metalloproteinases","volume":"166","author":"Vallon","year":"2001","journal-title":"J Immunol"},{"key":"B8","first-page":"90","article-title":"Inflammatory mediators and acute phase proteins in patients with Crohn\u2019s disease and ulcerative colitis","volume":"44","author":"Niederau","year":"1997","journal-title":"Hepatogastroenterology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e287","DOI":"10.1371\/journal.pmed.0030287","article-title":"Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications","volume":"3","author":"Yang","year":"2006","journal-title":"PLoS Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1002\/oby.20657","article-title":"Decrease of circulating SAA is correlated with reduction of abdominal SAA secretion during weight loss","volume":"22","author":"Yang","year":"2014","journal-title":"Obesity (Silver Spring)"},{"key":"B11","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1530\/EJE-07-0598","article-title":"Serum concentrations and expressions of serum amyloid A and leptin in adipose tissue are interrelated: the Genobin study","volume":"158","author":"Lappalainen","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1158\/1055-9965.EPI-12-1020","article-title":"Serum amyloid a is associated with obesity and estrogen receptor-negative tumors in postmenopausal women with breast cancer","volume":"22","author":"Santana","year":"2013","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"B13","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s00011-010-0163-y","article-title":"Association between serum amyloid A and obesity: a meta-analysis and systematic review","volume":"59","author":"Zhao","year":"2010","journal-title":"Inflamm Res"},{"key":"B14","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/s0021-9150(02)00371-4","article-title":"Insulin resistance and adiposity correlate with acute-phase reaction and soluble cell adhesion molecules in type 2 diabetes","volume":"166","author":"Leinonen","year":"2003","journal-title":"Atherosclerosis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.2337\/dc12-1514","article-title":"Acute-phase serum amyloid A protein and its implication in the development of type 2 diabetes in the KORA S4\/F4 study","volume":"36","author":"Marzi","year":"2013","journal-title":"Diabetes Care"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2914","DOI":"10.1161\/01.CIR.96.9.2914","article-title":"Association between serum amyloid A proteins and coronary artery disease: evidence from two distinct arteriosclerotic processes","volume":"96","author":"Fyfe","year":"1997","journal-title":"Circulation"},{"key":"B17","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1253\/circj.71.186","article-title":"Serum amyloid A is a better predictor of clinical outcomes than C-reactive protein in non-ST-segment elevation acute coronary syndromes","volume":"71","author":"Kosuge","year":"2007","journal-title":"Circ J"},{"key":"B18","doi-asserted-by":"publisher","first-page":"3186","DOI":"10.1073\/pnas.91.8.3186","article-title":"Expression of apolipoprotein serum amyloid A mRNA in human atherosclerotic lesions and cultured vascular cells: implications for serum amyloid A function","volume":"91","author":"Meek","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B19","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1161\/01.CIR.0000115516.54550.B1","article-title":"Serum amyloid A as a predictor of coronary artery disease and cardiovascular outcome in women: the national heart, lung, and blood institute-sponsored women\u2019s ischemia syndrome evaluation (WISE)","volume":"109","author":"Johnson","year":"2004","journal-title":"Circulation"},{"key":"B20","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s10020-018-0047-0","article-title":"Serum amyloid A\u2014a review","volume":"24","author":"Sack","year":"2018","journal-title":"Mol Med"},{"key":"B21","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1097\/MOL.0000000000000331","article-title":"Serum amyloid A and atherosclerosis","volume":"27","author":"Getz","year":"2016","journal-title":"Curr Opin Lipidol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1006\/geno.1994.1052","article-title":"Evolution of the serum amyloid A (SAA) protein superfamily","volume":"19","author":"Uhlar","year":"1994","journal-title":"Genomics"},{"key":"B23","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.fsi.2022.02.038","article-title":"Serum amyloid protein (SAA) as a healthy marker for immune function in Tridacna crocea","volume":"122","author":"Wang","year":"2022","journal-title":"Fish Shellfish Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"4025","DOI":"10.1073\/pnas.74.9.4025","article-title":"Amyloid protein SAA is associated with high density lipoprotein from human serum","volume":"74","author":"Benditt","year":"1977","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B25","doi-asserted-by":"publisher","first-page":"4092","DOI":"10.1073\/pnas.76.8.4092","article-title":"Amyloid protein SAA is an apoprotein of mouse plasma high density lipoprotein","volume":"76","author":"Benditt","year":"1979","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B26","doi-asserted-by":"publisher","first-page":"4004","DOI":"10.4049\/jimmunol.155.8.4004","article-title":"Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway","volume":"155","author":"Badolato","year":"1995","journal-title":"J Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1074\/jbc.RA119.010626","article-title":"Serum amyloid A exhibits pH dependent antibacterial action and contributes to host defense against","volume":"295","author":"Zheng","year":"2020","journal-title":"J Biol Chem"},{"key":"B28","doi-asserted-by":"publisher","first-page":"6128","DOI":"10.1128\/JVI.02627-06","article-title":"Human serum amyloid A protein inhibits hepatitis C virus entry into cells","volume":"81","author":"Cai","year":"2007","journal-title":"J Virol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3109\/13506120209072440","article-title":"Channel formation by serum amyloid A: a potential mechanism for amyloid pathogenesis and host defense","volume":"9","author":"Hirakura","year":"2002","journal-title":"Amyloid"},{"key":"B30","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1002\/jlb.67.3.381","article-title":"Serum amyloid A is an activator of PMN antimicrobial functions: induction of degranulation, phagocytosis, and enhancement of anti-Candida activity","volume":"67","author":"Badolato","year":"2000","journal-title":"J Leukoc Biol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1084\/jem.180.1.203","article-title":"Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes","volume":"180","author":"Badolato","year":"1994","journal-title":"J Exp Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1006\/bbrc.2000.2416","article-title":"Serum amyloid A is a chemotactic agonist at FPR2, a low-affinity N-formylpeptide receptor on mouse neutrophils","volume":"270","author":"Liang","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"B33","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1084\/jem.189.2.395","article-title":"A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells","volume":"189","author":"Su","year":"1999","journal-title":"J Exp Med"},{"key":"B34","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1006\/bbrc.1998.9911","article-title":"Serum amyloid A induces chemotaxis of human mast cells by activating a pertussis toxin-sensitive signal transduction pathway","volume":"254","author":"Olsson","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"B35","doi-asserted-by":"publisher","first-page":"9644","DOI":"10.1016\/S0021-9258(18)67562-3","article-title":"Serum amyloid A-containing human high density lipoprotein 3. Density, size, and apolipoprotein composition","volume":"261","author":"Coetzee","year":"1986","journal-title":"J Biol Chem"},{"key":"B36","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1749-6632.1982.tb22136.x","article-title":"SAA, an apoprotein of HDL: its structure and function","volume":"389","author":"Benditt","year":"1982","journal-title":"Ann N Y Acad Sci"},{"key":"B37","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1002\/oby.20126","article-title":"Serum amyloid A is found on ApoB-containing lipoproteins in obese humans with diabetes","volume":"21","author":"Jahangiri","year":"2013","journal-title":"Obesity (Silver Spring)"},{"key":"B38","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1189\/jlb.3VMR0315-080R","article-title":"Emerging functions of serum amyloid A in inflammation","volume":"98","author":"Ye","year":"2015","journal-title":"J Leukoc Biol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s11883-020-00901-4","article-title":"High-density lipoproteins and serum amyloid A (SAA)","volume":"23","author":"Webb","year":"2021","journal-title":"Curr Atheroscler Rep"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1084\/jem.164.6.2006","article-title":"Amyloid A gene family expression in different mouse tissues","volume":"164","author":"Meek","year":"1986","journal-title":"J Exp Med"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.14670\/HH-20.1295","article-title":"Extrahepatic production of acute phase serum amyloid A","volume":"20","author":"Upragarin","year":"2005","journal-title":"Histol Histopathol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"10397","DOI":"10.1038\/s41598-020-66898-7","article-title":"Presence of serum amyloid A3 in mouse plasma is dependent on the nature and extent of the inflammatory stimulus","volume":"10","author":"Chait","year":"2020","journal-title":"Sci Rep"},{"key":"B43","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1089\/dna.1991.10.651","article-title":"Nonexpression of the human serum amyloid A three (SAA3) gene","volume":"10","author":"Kluve-Beckerman","year":"1991","journal-title":"DNA Cell Biol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.2174\/0929867323666160418114600","article-title":"Structure and expression of different Serum amyloid A (SAA) variants and their concentration-dependent functions during host insults","volume":"23","author":"De Buck","year":"2016","journal-title":"Curr Med Chem"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1016\/S0006-291X(03)00045-7","article-title":"Induction of human mammary-associated serum amyloid A3 expression by prolactin or lipopolysaccharide","volume":"301","author":"Larson","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"B46","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1046\/j.1432-1327.1999.00657.x","article-title":"Serum amyloid A, the major vertebrate acute-phase reactant","volume":"265","author":"Uhlar","year":"1999","journal-title":"Eur J Biochem"},{"key":"B47","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1006\/geno.1996.0253","article-title":"Structure of the mouse Saa4 gene and its linkage to the serum amyloid A gene family","volume":"34","author":"de Beer","year":"1996","journal-title":"Genomics"},{"key":"B48","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1124\/mol.105.022103","article-title":"Serum amyloid A induces contrary immune responses via formyl peptide receptor-like 1 in human monocytes","volume":"70","author":"Lee","year":"2006","journal-title":"Mol Pharmacol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1182\/blood-2002-05-1431","article-title":"Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1\/LXA4R","volume":"101","author":"He","year":"2003","journal-title":"Blood"},{"key":"B50","doi-asserted-by":"publisher","first-page":"302","DOI":"10.3858\/emm.2010.42.4.029","article-title":"A pertussis toxin sensitive G-protein-independent pathway is involved in serum amyloid A-induced formyl peptide receptor 2-mediated CCL2 production","volume":"42","author":"Lee","year":"2010","journal-title":"Exp Mol Med"},{"key":"B51","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1189\/jlb.0507276","article-title":"Serum amyloid A inhibits apoptosis of human neutrophils via a P2X7-sensitive pathway independent of formyl peptide receptor-like 1","volume":"83","author":"Christenson","year":"2008","journal-title":"J Leukoc Biol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"515","DOI":"10.2119\/molmed.2015.00109","article-title":"Serum amyloid A stimulates PKR expression and HMGB1 release possibly through TLR4\/RAGE receptors","volume":"21","author":"Li","year":"2015","journal-title":"Mol Med"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1016\/S0002-9440(10)63917-X","article-title":"Advanced glycation end products and receptor for advanced glycation end products in AA amyloidosis","volume":"162","author":"R\u00f6cken","year":"2003","journal-title":"Am J Pathol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/76216","article-title":"Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis","volume":"6","author":"Yan","year":"2000","journal-title":"Nat Med"},{"key":"B55","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3109\/13506129.2015.1112782","article-title":"The pattern recognition reagents RAGE VC1 and peptide p5 share common binding sites and exhibit specific reactivity with AA amyloid in mice","volume":"23","author":"Kennel","year":"2016","journal-title":"Amyloid"},{"key":"B56","doi-asserted-by":"publisher","first-page":"22","DOI":"10.4049\/jimmunol.181.1.22","article-title":"Cutting edge: TLR2 is a functional receptor for acute-phase serum amyloid A","volume":"181","author":"Cheng","year":"2008","journal-title":"J Immunol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"12804","DOI":"10.1074\/jbc.M114.635763","article-title":"Hepatic serum amyloid A1 aggravates T cell-mediated hepatitis by inducing chemokines via Toll-like receptor 2 in mice","volume":"290","author":"Ji","year":"2015","journal-title":"J Biol Chem"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1038\/ncb1794","article-title":"The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase","volume":"10","author":"Hiratsuka","year":"2008","journal-title":"Nat Cell Biol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1189\/jlb.0407203","article-title":"Is serum amyloid A an endogenous TLR4 agonist?","volume":"83","author":"Sandri","year":"2008","journal-title":"J Leukoc Biol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.4049\/jimmunol.1201996","article-title":"Serum amyloid A3 binds MD-2 to activate p38 and NF-\u03baB pathways in a MyD88-dependent manner","volume":"191","author":"Deguchi","year":"2013","journal-title":"J Immunol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"B62","doi-asserted-by":"publisher","first-page":"e0118835","DOI":"10.1371\/journal.pone.0118835","article-title":"Human serum amyloid A3 (SAA3) protein, expressed as a fusion protein with SAA2, binds the oxidized low density lipoprotein receptor","volume":"10","author":"Tomita","year":"2015","journal-title":"PLoS One"},{"key":"B63","doi-asserted-by":"publisher","first-page":"2954","DOI":"10.1074\/jbc.M411555200","article-title":"Serum amyloid A is a ligand for scavenger receptor class B type I and inhibits high density lipoprotein binding and selective lipid uptake","volume":"280","author":"Cai","year":"2005","journal-title":"J Biol Chem"},{"key":"B64","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1056\/NEJMoa065644","article-title":"Eprodisate for the treatment of renal disease in AA amyloidosis","volume":"356","author":"Dember","year":"2007","journal-title":"N Engl J Med"},{"key":"B65","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.metabol.2010.05.011","article-title":"Expression of the selenoprotein S (SELS) gene in subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors","volume":"60","author":"Olsson","year":"2011","journal-title":"Metab Clin Exp"},{"key":"B66","doi-asserted-by":"publisher","first-page":"35890","DOI":"10.1074\/jbc.M505685200","article-title":"Serum amyloid A promotes cholesterol efflux mediated by scavenger receptor B-I","volume":"280","author":"van der Westhuyzen","year":"2005","journal-title":"J Biol Chem"},{"key":"B67","doi-asserted-by":"publisher","first-page":"8031","DOI":"10.1074\/jbc.M405009200","article-title":"Serum amyloid A binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1\/2 and p38 mitogen-activated protein kinases","volume":"280","author":"Baranova","year":"2005","journal-title":"J Biol Chem"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.2337\/diabetes.51.6.1859","article-title":"Tanis: a link between type 2 diabetes and inflammation?","volume":"51","author":"Walder","year":"2002","journal-title":"Diabetes"},{"key":"B69","doi-asserted-by":"publisher","first-page":"25395","DOI":"10.1016\/S0021-9258(19)74405-6","article-title":"Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains","volume":"268","author":"Gao","year":"1993","journal-title":"J Biol Chem"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1119227","DOI":"10.3389\/fendo.2023.1119227","article-title":"Acute-serum amyloid A and A-SAA-derived peptides as formyl peptide receptor (FPR) 2 ligands","volume":"14","author":"Abouelasrar Salama","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B71","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.cytogfr.2015.12.010","article-title":"The cytokine-serum amyloid A-chemokine network","volume":"30","author":"De Buck","year":"2016","journal-title":"Cytokine Growth Factor Rev"},{"key":"B72","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.4049\/jimmunol.177.4.2601","article-title":"Inflammation-responsive transcription factor SAF-1 activity is linked to the development of amyloid A amyloidosis","volume":"177","author":"Ray","year":"2006","journal-title":"J Immunol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.2337\/diabetes.53.6.1424","article-title":"Relationship between serum amyloid A level and Tanis\/SelS mRNA expression in skeletal muscle and adipose tissue from healthy and type 2 diabetic subjects","volume":"53","author":"Karlsson","year":"2004","journal-title":"Diabetes"},{"key":"B74","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1042\/bj3340489","article-title":"Regulation of serum amyloid A protein expression during the acute-phase response","volume":"334","author":"Jensen","year":"1998","journal-title":"Biochem J"},{"key":"B75","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/sj.jp.7211682","article-title":"Serum amyloid A: an early and accurate marker of neonatal early-onset sepsis","volume":"27","author":"Arnon","year":"2007","journal-title":"J Perinatol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.intimp.2018.07.024","article-title":"Prognostic value of the biomarkers serum amyloid A and nitric oxide in patients with sepsis","volume":"62","author":"Yu","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"e28880","DOI":"10.1097\/MD.0000000000028880","article-title":"Prognostic value of serum amyloid A in COVID-19: a meta-analysis","volume":"101","author":"Li","year":"2022","journal-title":"Medicine (Baltimore)"},{"key":"B78","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1093\/clinchem\/39.2.293","article-title":"Monitoring both serum amyloid protein A and C-reactive protein as inflammatory markers in infectious diseases","volume":"39","author":"Nakayama","year":"1993","journal-title":"Clin Chem"},{"key":"B79","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.abb.2019.07.013","article-title":"Acute phase protein response to viral infection and vaccination","volume":"671","author":"Perez","year":"2019","journal-title":"Arch Biochem Biophys"},{"key":"B80","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.1016\/j.ajpath.2015.06.016","article-title":"Hepatic expression of serum amyloid A1 is induced by traumatic brain injury and modulated by telmisartan","volume":"185","author":"Villapol","year":"2015","journal-title":"Am J Pathol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1007\/s10571-020-00808-3","article-title":"Serum amyloid A is expressed in the brain after traumatic brain injury in a sex-dependent manner","volume":"40","author":"Soriano","year":"2020","journal-title":"Cell Mol Neurobiol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"e108564","DOI":"10.1371\/journal.pone.0108564","article-title":"Deletion of serum amyloid A3 improves high fat high sucrose diet-induced adipose tissue inflammation and hyperlipidemia in female mice","volume":"9","author":"den Hartigh","year":"2014","journal-title":"PLoS One"},{"key":"B83","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1161\/ATVBAHA.111.232348","article-title":"Age as a modulator of inflammatory cardiovascular risk factors","volume":"31","author":"Anuurad","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"754","DOI":"10.3389\/fimmu.2018.00754","article-title":"Role of C-reactive protein at sites of inflammation and infection","volume":"9","author":"Sproston","year":"2018","journal-title":"Front Immunol"},{"key":"B85","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/s0065-2776(08)60379-x","article-title":"Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein","volume":"34","author":"Pepys","year":"1983","journal-title":"Adv Immunol"},{"key":"B86","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1042\/cs0680233","article-title":"Comparative study of serum amyloid A protein and C-reactive protein in disease","volume":"68","author":"Maury","year":"1985","journal-title":"Clin Sci (Lond)"},{"key":"B87","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1136\/ard.50.10.677","article-title":"Comparative study of C reactive protein and serum amyloid A protein in experimental inflammation","volume":"50","author":"Chambers","year":"1991","journal-title":"Ann Rheum Dis"},{"key":"B88","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1210\/jc.2004-1011","article-title":"Diet-induced weight loss is associated with decreases in plasma serum amyloid a and C-reactive protein independent of dietary macronutrient composition in obese subjects","volume":"90","author":"O\u2019Brien","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"B89","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/j.0300-9475.2004.01369.x","article-title":"Regulation of the human acute phase serum amyloid A genes by tumour necrosis factor-alpha, interleukin-6 and glucocorticoids in hepatic and epithelial cell lines","volume":"59","author":"Thorn","year":"2004","journal-title":"Scand J Immunol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.3390\/cells11142163","article-title":"The association of acute phase proteins in stress and inflammation-induced T2D","volume":"11","author":"Speelman","year":"2022","journal-title":"Cells"},{"key":"B91","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1515\/hsz-2021-0209","article-title":"Acute-phase protein synthesis: a key feature of innate immune functions of the liver","volume":"402","author":"Ehlting","year":"2021","journal-title":"Biol Chem"},{"key":"B92","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/s12020-013-9938-6","article-title":"Relationship of thyroid hormone levels and cardiovascular events in patients with type 2 diabetes","volume":"45","author":"Moura Neto","year":"2014","journal-title":"Endocrine"},{"key":"B93","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s12020-015-0651-5","article-title":"Relation of thyroid hormone abnormalities with subclinical inflammatory activity in patients with type 1 and type 2 diabetes mellitus","volume":"51","author":"Moura Neto","year":"2016","journal-title":"Endocrine"},{"key":"B94","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1136\/jcp.36.7.798","article-title":"Comparison of serum amyloid A protein and C-reactive protein concentrations in cancer and non-malignant disease","volume":"36","author":"Raynes","year":"1983","journal-title":"J Clin Pathol"},{"key":"B95","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1093\/ageing\/26.2.153","article-title":"Acute phase proteins, C-reactive protein and serum amyloid A protein, as prognostic markers in the elderly inpatient","volume":"26","author":"Hogarth","year":"1997","journal-title":"Age Ageing"},{"key":"B96","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1007\/s00125-004-1654-6","article-title":"Serum amyloid A: production by human white adipocyte and regulation by obesity and nutrition","volume":"48","author":"Poitou","year":"2005","journal-title":"Diabetologia"},{"key":"B97","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1210\/jc.2004-1830","article-title":"A microarray search for genes predominantly expressed in human omental adipocytes: adipose tissue as a major production site of serum amyloid A","volume":"90","author":"Sj\u00f6holm","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"B98","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/oby.2006.40","article-title":"Serum amyloid A: a marker of adiposity-induced low-grade inflammation but not of metabolic status","volume":"14","author":"Poitou","year":"2006","journal-title":"Obesity (Silver Spring)"},{"key":"B99","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1161\/01.CIR.0000158479.58589.0A","article-title":"Inflammatory markers at the site of ruptured plaque in acute myocardial infarction: locally increased interleukin-6 and serum amyloid A but decreased C-reactive protein","volume":"111","author":"Maier","year":"2005","journal-title":"Circulation"},{"key":"B100","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1111\/j.1440-1827.1996.tb03552.x","article-title":"Both acute phase and constitutive serum amyloid A are present in atherosclerotic lesions","volume":"46","author":"Yamada","year":"1996","journal-title":"Pathol Int"},{"key":"B101","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1172\/JCI107985","article-title":"Variation with age and disease of an amyloid A protein-related serum component","volume":"55","author":"Rosenthal","year":"1975","journal-title":"J Clin Invest"},{"key":"B102","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1016\/j.bbalip.2013.06.004","article-title":"Aging affects high-density lipoprotein composition and function","volume":"1831","author":"Holzer","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"B103","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1053\/euhj.1998.1309","article-title":"Risk factors for coronary heart disease and acute-phase proteins. A population-based study","volume":"20","author":"Danesh","year":"1999","journal-title":"Eur Heart J"},{"key":"B104","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1210\/jc.2008-0701","article-title":"Adipokines, inflammation, and visceral adiposity across the menopausal transition: a prospective study","volume":"94","author":"Lee","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1194\/jlr.M900089-JLR200","article-title":"Serum amyloid A3 does not contribute to circulating SAA levels","volume":"50","author":"Chiba","year":"2009","journal-title":"J Lipid Res"},{"key":"B106","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1096\/fj.05-5678fje","article-title":"Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression","volume":"20","author":"Jern\u00e5s","year":"2006","journal-title":"FASEB J"},{"key":"B107","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.cyto.2009.08.005","article-title":"Association of serum amyloid A levels with adipocyte size and serum levels of adipokines: differences between men and women","volume":"48","author":"Sj\u00f6holm","year":"2009","journal-title":"Cytokine"},{"key":"B108","doi-asserted-by":"publisher","first-page":"E1176","DOI":"10.1210\/jc.2011-2380","article-title":"Adipose tissue secretion and expression of adipocyte-produced and stromavascular fraction-produced adipokines vary during multiple phases of weight-reducing dietary intervention in obese women","volume":"97","author":"Siklova-Vitkova","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"B109","doi-asserted-by":"publisher","first-page":"2314","DOI":"10.1158\/0008-5472.CAN-11-3092","article-title":"Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight\/obese postmenopausal women: a randomized controlled trial","volume":"72","author":"Imayama","year":"2012","journal-title":"Cancer Res"},{"key":"B110","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1007\/s11695-008-9424-z","article-title":"Proinflammatory cytokines in obesity: impact of type 2 diabetes mellitus and gastric bypass","volume":"17","author":"Catal\u00e1n","year":"2007","journal-title":"Obes Surg"},{"key":"B111","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1084\/jem.169.5.1841","article-title":"Expression of the third member of the serum amyloid A gene family in mouse adipocytes","volume":"169","author":"Benditt","year":"1989","journal-title":"J Exp Med"},{"key":"B112","doi-asserted-by":"publisher","first-page":"7949","DOI":"10.1073\/pnas.89.17.7949","article-title":"Murine serum amyloid A3 is a high density apolipoprotein and is secreted by macrophages","volume":"89","author":"Meek","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B113","doi-asserted-by":"publisher","first-page":"3849","DOI":"10.4049\/jimmunol.139.11.3849","article-title":"Differential expression of the amyloid SAA 3 gene in liver and peritoneal macrophages of mice undergoing dissimilar inflammatory episodes","volume":"139","author":"Rokita","year":"1987","journal-title":"J Immunol"},{"key":"B114","doi-asserted-by":"publisher","first-page":"42077","DOI":"10.1074\/jbc.M107101200","article-title":"Hyperglycemia-induced production of acute phase reactants in adipose tissue","volume":"276","author":"Lin","year":"2001","journal-title":"J Biol Chem"},{"key":"B115","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1101\/gad.14.8.963","article-title":"Leptin-specific patterns of gene expression in white adipose tissue","volume":"14","author":"Soukas","year":"2000","journal-title":"Genes Dev"},{"key":"B116","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1161\/ATVBAHA.107.157685","article-title":"Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese LDL receptor-deficient mice","volume":"28","author":"Subramanian","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1194\/jlr.M016246","article-title":"Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice","volume":"52","author":"Subramanian","year":"2011","journal-title":"J Lipid Res"},{"key":"B118","doi-asserted-by":"publisher","first-page":"107818","DOI":"10.1016\/j.celrep.2020.107818","article-title":"Adipocyte-derived versican and macrophage-derived biglycan control adipose tissue inflammation in obesity","volume":"31","author":"Han","year":"2020","journal-title":"Cell Rep"},{"key":"B119","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1161\/ATVBAHA.116.308749","article-title":"Adipocyte-specific deficiency of NADPH oxidase 4 delays the onset of insulin resistance and attenuates adipose tissue inflammation in obesity","volume":"37","author":"Den Hartigh","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B120","doi-asserted-by":"publisher","first-page":"230837","DOI":"10.1155\/2008\/230837","article-title":"Acute-phase serum amyloid A as a marker of insulin resistance in mice","volume":"2008","author":"Scheja","year":"2008","journal-title":"Exp Diabetes Res"},{"key":"B121","doi-asserted-by":"publisher","first-page":"38697","DOI":"10.1038\/srep38697","article-title":"Serum amyloid A3 gene expression in adipocytes is an indicator of the interaction with macrophages","volume":"6","author":"Sanada","year":"2016","journal-title":"Sci Rep"},{"key":"B122","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1194\/jlr.M080887","article-title":"Serum amyloid A3 is a high density lipoprotein-associated acute-phase protein","volume":"59","author":"Tannock","year":"2018","journal-title":"J Lipid Res"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.3390\/nu9030311","article-title":"Serum amyloid A production is triggered by sleep deprivation in mice and humans: is that the link between sleep loss and associated comorbidities?","volume":"9","author":"de Oliveira","year":"2017","journal-title":"Nutrients"},{"key":"B124","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1161\/01.CIR.0000089091.09527.B8","article-title":"Serum amyloid a in obstructive sleep apnea","volume":"108","author":"Svatikova","year":"2003","journal-title":"Circulation"},{"key":"B125","doi-asserted-by":"publisher","first-page":"467","DOI":"10.5664\/jcsm.26910","article-title":"Relationship of metabolic syndrome and obstructive sleep apnea","volume":"3","author":"Parish","year":"2007","journal-title":"J Clin Sleep Med"},{"key":"B126","doi-asserted-by":"publisher","first-page":"e19609","DOI":"10.1371\/journal.pone.0019609","article-title":"Establishment of a transgenic mouse model specifically expressing human serum amyloid A in adipose tissue","volume":"6","author":"Olsson","year":"2011","journal-title":"PLoS One"},{"key":"B127","doi-asserted-by":"publisher","first-page":"e72204","DOI":"10.1371\/journal.pone.0072204","article-title":"No evidence for a role of adipose tissue-derived Serum amyloid A in the development of insulin resistance or obesity-related inflammation in hSAA1(+\/-) transgenic mice","volume":"8","author":"Ahlin","year":"2013","journal-title":"PLoS One"},{"key":"B128","doi-asserted-by":"publisher","first-page":"e0192352","DOI":"10.1371\/journal.pone.0192352","article-title":"Serum amyloid A3 is required for normal weight and immunometabolic function in mice","volume":"13","author":"Ather","year":"2018","journal-title":"PLoS One"},{"key":"B129","doi-asserted-by":"publisher","first-page":"e0266688","DOI":"10.1371\/journal.pone.0266688","article-title":"Serum amyloid A is not obligatory for high-fat, high-sucrose, cholesterol-fed diet-induced obesity and its metabolic and inflammatory complications","volume":"17","author":"Ji","year":"2022","journal-title":"PLoS One"},{"key":"B130","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1080\/21623945.2021.1916220","article-title":"Serum amyloid A3 deficiency impairs in vitro and in vivo adipocyte differentiation","volume":"10","author":"Vercalsteren","year":"2021","journal-title":"Adipocyte"},{"key":"B131","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1007\/s00125-016-3970-z","article-title":"Serum amyloid A links endotoxaemia to weight gain and insulin resistance in mice","volume":"59","author":"de Oliveira","year":"2016","journal-title":"Diabetologia"},{"key":"B132","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1101\/gad.1550907","article-title":"Mechanisms of obesity-associated insulin resistance: many choices on the menu","volume":"21","author":"Qatanani","year":"2007","journal-title":"Genes Dev"},{"key":"B133","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cphy.c170040","article-title":"Contribution of adipose tissue inflammation to the development of type 2 diabetes Mellitus","volume":"9","author":"Burhans","year":"2018","journal-title":"Compr Physiol"},{"key":"B134","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1038\/nature05482","article-title":"Mechanisms linking obesity to insulin resistance and type 2 diabetes","volume":"444","author":"Kahn","year":"2006","journal-title":"Nature"},{"key":"B135","doi-asserted-by":"publisher","first-page":"5366","DOI":"10.1210\/jcem.86.11.7992","article-title":"Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians","volume":"86","author":"Raji","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"B136","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.2337\/diacare.22.8.1310","article-title":"Dual energy x-ray absorptiometry assessment of fat mass distribution and its association with the insulin resistance syndrome","volume":"22","author":"Paradisi","year":"1999","journal-title":"Diabetes Care"},{"key":"B137","doi-asserted-by":"publisher","first-page":"1314864","DOI":"10.1155\/2017\/1314864","article-title":"Type 2 diabetes in young females results in increased Serum amyloid A and changes to features of high density lipoproteins in both HDL2 and HDL3","volume":"2017","author":"Griffiths","year":"2017","journal-title":"J Diabetes Res"},{"key":"B138","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.atherosclerosis.2013.10.008","article-title":"Impact of serum amyloid A on cellular cholesterol efflux to serum in type 2 diabetes mellitus","volume":"231","author":"Tsun","year":"2013","journal-title":"Atherosclerosis"},{"key":"B139","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.3760\/cma.j.issn.0366-6999.2009.21.007","article-title":"Effects of five-year intensive multifactorial intervention on the serum amyloid A and macroangiopathy in patients with short-duration type 2 diabetes mellitus","volume":"122","author":"Du","year":"2009","journal-title":"Chin Med J (Engl)"},{"key":"B140","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/0009-9120(94)00044-v","article-title":"Serum amyloid A protein in patients with non-insulin-dependent diabetes mellitus","volume":"27","author":"Kumon","year":"1994","journal-title":"Clin Biochem"},{"key":"B141","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1161\/01.CIR.0000124718.99562.91","article-title":"Association of type 2 diabetes with cyclooxygenase-mediated inflammation and oxidative stress in an elderly population","volume":"109","author":"Helmersson","year":"2004","journal-title":"Circulation"},{"key":"B142","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1038\/oby.2009.443","article-title":"Subcutaneous and visceral adipose tissue gene expression of serum adipokines that predict type 2 diabetes","volume":"18","author":"Samaras","year":"2010","journal-title":"Obesity (Silver Spring)"},{"key":"B143","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1161\/01.CIR.0000136819.93989.E1","article-title":"Increase in serum amyloid a evoked by dietary cholesterol is associated with increased atherosclerosis in mice","volume":"110","author":"Lewis","year":"2004","journal-title":"Circulation"},{"key":"B144","doi-asserted-by":"publisher","first-page":"e0115320","DOI":"10.1371\/journal.pone.0115320","article-title":"Serum amyloid a truncations in type 2 diabetes mellitus","volume":"10","author":"Yassine","year":"2015","journal-title":"PLoS One"},{"key":"B145","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1097\/00029330-200807010-00003","article-title":"Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus","volume":"121","author":"Du","year":"2008","journal-title":"Chin Med J (Engl)"},{"key":"B146","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1007\/BF03346510","article-title":"Serum amyloid A attenuates cellular insulin sensitivity by increasing JNK activity in 3T3-L1 adipocytes","volume":"32","author":"Ye","year":"2009","journal-title":"J Endocrinol Invest"},{"key":"B147","doi-asserted-by":"publisher","first-page":"e24283","DOI":"10.1002\/jcla.24283","article-title":"Associations of serum amyloid A and 25-hydroxyvitamin D with diabetic nephropathy: a cross-sectional study","volume":"36","author":"Liu","year":"2022","journal-title":"J Clin Lab Anal"},{"key":"B148","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1900\/RDS.2007.4.98","article-title":"Association between low-grade systemic inflammation and type 2 diabetes mellitus among men and women from the ATTICA study","volume":"4","author":"Pitsavos","year":"2007","journal-title":"Rev Diabet Stud"},{"key":"B149","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1007\/s001250051315","article-title":"Troglitazone reduces hyperglycaemia and selectively acute-phase serum proteins in patients with type II diabetes","volume":"42","author":"Ebeling","year":"1999","journal-title":"Diabetologia"},{"key":"B150","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1186\/s13023-019-1188-0","article-title":"The cardiovascular phenotype of adult patients with phenylketonuria","volume":"14","author":"Azabdaftari","year":"2019","journal-title":"Orphanet J Rare Dis"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051069","article-title":"Cytokine levels in human vitreous in proliferative diabetic retinopathy","volume":"10","author":"Loporchio","year":"2021","journal-title":"Cells"},{"key":"B152","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1016\/j.jdiacomp.2016.07.018","article-title":"Serum amyloid a and risk of death and end-stage renal disease in diabetic kidney disease","volume":"30","author":"Dieter","year":"2016","journal-title":"J Diabetes Complications"},{"key":"B153","doi-asserted-by":"publisher","first-page":"S78","DOI":"10.1681\/asn.2004110961","article-title":"Acute-phase markers of inflammation and glomerular structure in patients with type 2 diabetes","volume":"16","author":"Dalla Vestra","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020899","article-title":"Serum amyloid A3 promoter-driven luciferase activity enables visualization of diabetic kidney disease","volume":"23","author":"Saliu","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B155","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.3109\/09513590.2012.705371","article-title":"Association of serum amyloid A with subclinical atherosclerosis in women with gestational diabetes","volume":"28","author":"Eren","year":"2012","journal-title":"Gynecol Endocrinol"},{"key":"B156","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1002\/oby.21617","article-title":"Maternal diet, gestational weight gain, and inflammatory markers during pregnancy","volume":"24","author":"Hrolfsdottir","year":"2016","journal-title":"Obesity (Silver Spring)"},{"key":"B157","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/dmrr.1170","article-title":"Decreased variation of inflammatory markers in gestational diabetes","volume":"27","author":"P\u00f6yh\u00f6nen-Alho","year":"2011","journal-title":"Diabetes Metab Res Rev"},{"key":"B158","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1210\/edrv.18.6.0318","article-title":"Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocr Rev"},{"key":"B159","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1385\/ENDO:30:1:13","article-title":"Insulin resistance in PCOS","volume":"30","author":"Diamanti-Kandarakis","year":"2006","journal-title":"Endocrine"},{"key":"B160","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.atherosclerosis.2010.08.069","article-title":"The anti-atherogenic aspect of metformin treatment in insulin resistant women with the polycystic ovary syndrome: role of the newly established pro-inflammatory adipokine acute-phase serum amyloid A; evidence of an adipose tissue-monocyte axis","volume":"216","author":"Tan","year":"2011","journal-title":"Atherosclerosis"},{"key":"B161","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.biochi.2004.11.012","article-title":"Effects of testosterone on fat cell lipolysis. Species differences and possible role in polycystic ovarian syndrome","volume":"87","author":"Arner","year":"2005","journal-title":"Biochimie"},{"key":"B162","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/S2213-8587(14)70032-4","article-title":"Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome","volume":"2","author":"Yki-J\u00e4rvinen","year":"2014","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B163","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1161\/01.CIR.0000111245.75752.C6","article-title":"Definition of metabolic syndrome: report of the national heart, lung, and blood institute\/American heart association conference on scientific issues related to definition","volume":"109","author":"Grundy","year":"2004","journal-title":"Circulation"},{"key":"B164","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.cca.2019.06.019","article-title":"Metabolic syndrome is an inflammatory disorder: a conspiracy between adipose tissue and phagocytes","volume":"496","author":"Reddy","year":"2019","journal-title":"Clin Chim Acta"},{"key":"B165","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.arcmed.2011.05.002","article-title":"Lower serum paraoxonase-1 activity is related to higher serum amyloid a levels in metabolic syndrome","volume":"42","author":"Kappelle","year":"2011","journal-title":"Arch Med Res"},{"key":"B166","doi-asserted-by":"publisher","first-page":"6440","DOI":"10.3748\/wjg.v25.i43.6440","article-title":"Serum amyloid A levels in patients with liver diseases","volume":"25","author":"Yuan","year":"2019","journal-title":"World J Gastroenterol"},{"key":"B167","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.metabol.2010.09.006","article-title":"The association between the metabolic syndrome and alanine amino transferase is mediated by insulin resistance via related metabolic intermediates (the cohort on diabetes and atherosclerosis Maastricht [CODAM] study)","volume":"60","author":"Jacobs","year":"2011","journal-title":"Metab Clin Exp"},{"key":"B168","doi-asserted-by":"publisher","first-page":"101462","DOI":"10.1016\/j.molmet.2022.101462","article-title":"Serum amyloid A1 exacerbates hepatic steatosis via TLR4-mediated NF-\u03baB signaling pathway","volume":"59","author":"Jiang","year":"2022","journal-title":"Mol Metab"},{"key":"B169","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.bbrc.2021.02.124","article-title":"Hepatocytes derived increased SAA1 promotes intrahepatic platelet aggregation and aggravates liver inflammation in NAFLD","volume":"555","author":"Li","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"B170","doi-asserted-by":"publisher","first-page":"e0184084","DOI":"10.1371\/journal.pone.0184084","article-title":"Interleukin-1\u03b1 and interleukin-1\u03b2 play a central role in the pathogenesis of fulminant hepatic failure in mice","volume":"12","author":"Sultan","year":"2017","journal-title":"PLoS One"},{"key":"B171","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1056\/NEJM198602203140806","article-title":"The pathogenesis of atherosclerosis--an update","volume":"314","author":"Ross","year":"1986","journal-title":"N Engl J Med"},{"key":"B172","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N Engl J Med"},{"key":"B173","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1056\/NEJM200003233421202","article-title":"C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women","volume":"342","author":"Ridker","year":"2000","journal-title":"N Engl J Med"},{"key":"B174","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/s0021-9150(00)00681-x","article-title":"The association of c-reactive protein, serum amyloid a and fibrinogen with prevalent coronary heart disease--baseline findings of the PAIS project","volume":"156","author":"Jousilahti","year":"2001","journal-title":"Atherosclerosis"},{"key":"B175","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1161\/01.ATV.0000158383.65277.2b","article-title":"Serum amyloid A and lipoprotein retention in murine models of atherosclerosis","volume":"25","author":"O\u2019Brien","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B176","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.2119\/molmed.2011.00186","article-title":"Serum amyloid A directly accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice","volume":"17","author":"Dong","year":"2011","journal-title":"Mol Med"},{"key":"B177","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1194\/jlr.M054015","article-title":"A brief elevation of serum amyloid A is sufficient to increase atherosclerosis","volume":"56","author":"Thompson","year":"2015","journal-title":"J Lipid Res"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.001858","article-title":"Serum amyloid A facilitates early lesion development in ldlr-\/- mice","volume":"4","author":"Krishack","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"B179","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1093\/cvr\/cvu224","article-title":"The role of the FPR2\/ALX receptor in atherosclerosis development and plaque stability","volume":"105","author":"Petri","year":"2015","journal-title":"Cardiovasc Res"},{"key":"B180","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1161\/ATVBAHA.114.304776","article-title":"Deficiency of endogenous acute-phase Serum amyloid A protects apoE-\/- mice from angiotensin II-induced abdominal aortic aneurysm formation","volume":"35","author":"Webb","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B181","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.atherosclerosis.2017.11.011","article-title":"Serum amyloid A3 is pro-atherogenic","volume":"268","author":"Thompson","year":"2017","journal-title":"Atherosclerosis"},{"key":"B182","doi-asserted-by":"publisher","first-page":"ATVBAHA121316066","DOI":"10.1161\/ATVBAHA.121.316066","article-title":"Sexually dimorphic relationships among Saa3 (Serum amyloid A3) inflammation, and cholesterol metabolism modulate atherosclerosis in mice","author":"Chait","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B183","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1161\/CIRCULATIONAHA.109.872796","article-title":"Human C-reactive protein does not promote atherosclerosis in transgenic rabbits","volume":"120","author":"Koike","year":"2009","journal-title":"Circulation"},{"key":"B184","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1161\/ATVBAHA.121.317225","article-title":"Adipocyte-Derived Serum amyloid A promotes angiotensin II-induced abdominal aortic aneurysms in obese C57BL\/6J mice","volume":"42","author":"Shridas","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B185","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1046\/j.1365-3083.2000.00734.x","article-title":"Serum amyloid A secretion from monocytic leukaemia cell line THP-1 and cultured human peripheral monocytes","volume":"52","author":"Yamada","year":"2000","journal-title":"Scand J Immunol"},{"key":"B186","doi-asserted-by":"publisher","first-page":"4662","DOI":"10.1021\/bi9624595","article-title":"Involvement of an SAF-like transcription factor in the activation of serum amyloid A gene in monocyte\/macrophage cells by lipopolysaccharide","volume":"36","author":"Ray","year":"1997","journal-title":"Biochemistry"},{"key":"B187","first-page":"650","article-title":"Human serum amyloid A genes are expressed in monocyte\/macrophage cell lines","volume":"145","author":"Urieli-Shoval","year":"1994","journal-title":"Am J Pathol"},{"key":"B188","doi-asserted-by":"publisher","first-page":"4941379","DOI":"10.1155\/2017\/4941379","article-title":"Serum amyloid A induces a vascular smooth muscle cell phenotype switch through the p38 MAPK signaling pathway","volume":"2017","author":"Zhang","year":"2017","journal-title":"Biomed Res Int"},{"key":"B189","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1007\/s13105-015-0462-4","article-title":"Serum amyloid A stimulates vascular endothelial growth factor receptor 2 expression and angiogenesis","volume":"72","author":"Lv","year":"2016","journal-title":"J Physiol Biochem"},{"key":"B190","doi-asserted-by":"publisher","first-page":"386","DOI":"10.2337\/db09-0925","article-title":"Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation","volume":"59","author":"Yeop Han","year":"2010","journal-title":"Diabetes"},{"key":"B191","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1172\/JCI83475","article-title":"Serum amyloid A impairs the antiinflammatory properties of HDL","volume":"126","author":"Han","year":"2016","journal-title":"J Clin Invest"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.142635","article-title":"Serum amyloid A-containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its antiinflammatory properties","volume":"5","author":"Han","year":"2020","journal-title":"JCI Insight"},{"key":"B193","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1194\/jlr.M059089","article-title":"Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity","volume":"56","author":"Vaisar","year":"2015","journal-title":"J Lipid Res"},{"key":"B194","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1161\/01.cir.98.6.519","article-title":"Comparison of apolipoprotein and proteoglycan deposits in human coronary atherosclerotic plaques: colocalization of biglycan with apolipoproteins","volume":"98","author":"O\u2019Brien","year":"1998","journal-title":"Circulation"},{"key":"B195","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1161\/ATVBAHA.111.226159","article-title":"Serum amyloid A facilitates the binding of high-density lipoprotein from mice injected with lipopolysaccharide to vascular proteoglycans","volume":"31","author":"Chiba","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B196","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1097\/00041433-199810000-00012","article-title":"The response-to-retention hypothesis of atherogenesis reinforced","volume":"9","author":"Williams","year":"1998","journal-title":"Curr Opin Lipidol"},{"key":"B197","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.atherosclerosis.2008.04.049","article-title":"Serum amyloid A may potentiate prothrombotic and proinflammatory events in acute coronary syndromes","volume":"202","author":"Song","year":"2009","journal-title":"Atherosclerosis"},{"key":"B198","doi-asserted-by":"publisher","first-page":"3102","DOI":"10.1038\/s41598-019-39056-x","article-title":"Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation","volume":"9","author":"Page","year":"2019","journal-title":"Sci Rep"},{"key":"B199","doi-asserted-by":"publisher","first-page":"M111.012203","DOI":"10.1074\/mcp.M111.012203","article-title":"Discovery and validation of serum protein changes in type 1 diabetes patients using high throughput two dimensional liquid chromatography-mass spectrometry and immunoassays","volume":"10","author":"Zhi","year":"2011","journal-title":"Mol Cell Proteomics"},{"key":"B200","doi-asserted-by":"publisher","first-page":"351601","DOI":"10.1155\/2015\/351601","article-title":"A cross-sectional study demonstrating increased Serum amyloid A related inflammation in high-density lipoproteins from subjects with type 1 diabetes Mellitus and how this association was augmented by poor glycaemic control","volume":"2015","author":"McEneny","year":"2015","journal-title":"J Diabetes Res"},{"key":"B201","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","article-title":"The mechanisms of alloxan- and streptozotocin-induced diabetes","volume":"51","author":"Lenzen","year":"2008","journal-title":"Diabetologia"},{"key":"B202","first-page":"91","article-title":"Studies on the diabetogenic action of streptozotocin (NSC-37917)","volume":"29","author":"Rakieten","year":"1963","journal-title":"Cancer Chemother Rep"},{"key":"B203","doi-asserted-by":"publisher","first-page":"6519785","DOI":"10.1155\/2017\/6519785","article-title":"Gut microbiome and inflammation: a study of diabetic inflammasome-knockout mice","volume":"2017","author":"Pahwa","year":"2017","journal-title":"J Diabetes Res"},{"key":"B204","doi-asserted-by":"publisher","first-page":"2964","DOI":"10.1194\/jlr.M035188","article-title":"10E,12Z-conjugated Linoleic acid impairs adipocyte triglyceride storage by enhancing fatty acid oxidation, lipolysis, and mitochondrial reactive oxygen species","volume":"54","author":"den Hartigh","year":"2013","journal-title":"J Lipid Res"},{"key":"B205","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.3892\/mmr.2014.2804","article-title":"Increased serum amyloid A and its association with autoantibodies, acute phase reactants and disease activity in patients with rheumatoid arthritis","volume":"11","author":"Shen","year":"2015","journal-title":"Mol Med Rep"},{"key":"B206","first-page":"993","article-title":"Biological markers in inflammatory rheumatic diseases","volume":"41","author":"Hilliquin","year":"1995","journal-title":"Cell Mol Biol (Noisy-le-Grand)"},{"key":"B207","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1136\/ard.41.3.268","article-title":"Relationship between urinary sialylated saccharides, serum amyloid A protein, and C-reactive protein in rheumatoid arthritis and systemic lupus erythematosus","volume":"41","author":"Maury","year":"1982","journal-title":"Ann Rheum Dis"},{"key":"B208","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1194\/jlr.M072165","article-title":"Commensal bacteria at the crossroad between cholesterol homeostasis and chronic inflammation in atherosclerosis","volume":"58","author":"Kasahara","year":"2017","journal-title":"J Lipid Res"},{"key":"B209","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.cell.2019.11.026","article-title":"Serum amyloid A proteins induce pathogenic Th17 cells and promote inflammatory disease","volume":"180","author":"Lee","year":"2020","journal-title":"Cell"},{"key":"B210","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.autrev.2006.10.002","article-title":"Autoimmune inflammation from the Th17 perspective","volume":"6","author":"Furuzawa-Carballeda","year":"2007","journal-title":"Autoimmun Rev"},{"key":"B211","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1136\/ard.42.6.665","article-title":"Serum amyloid-A protein concentration in rheumatoid arthritis and its role in monitoring disease activity","volume":"42","author":"Chambers","year":"1983","journal-title":"Ann Rheum Dis"},{"key":"B212","doi-asserted-by":"publisher","first-page":"e66769","DOI":"10.1371\/journal.pone.0066769","article-title":"Acute-phase serum amyloid a in osteoarthritis: regulatory mechanism and proinflammatory properties","volume":"8","author":"de Seny","year":"2013","journal-title":"PLoS One"},{"key":"B213","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1002\/art.20301","article-title":"Local expression of the serum amyloid A and formyl peptide receptor-like 1 genes in synovial tissue is associated with matrix metalloproteinase production in patients with inflammatory arthritis","volume":"50","author":"O\u2019Hara","year":"2004","journal-title":"Arthritis Rheum"},{"key":"B214","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1038\/mt.2009.182","article-title":"Computational design and application of endogenous promoters for transcriptionally targeted gene therapy for rheumatoid arthritis","volume":"17","author":"Geurts","year":"2009","journal-title":"Mol Ther"},{"key":"B215","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1002\/art.33455","article-title":"Acute-phase serum amyloid A regulates tumor necrosis factor \u03b1 and matrix turnover and predicts disease progression in patients with inflammatory arthritis before and after biologic therapy","volume":"64","author":"Connolly","year":"2012","journal-title":"Arthritis Rheum"},{"key":"B216","first-page":"535","article-title":"Serum amyloid A protein induces production of matrix metalloproteinases by human synovial fibroblasts","volume":"78","author":"Migita","year":"1998","journal-title":"Lab Invest"},{"key":"B217","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s13075-016-1009-y","article-title":"Differential response of serum amyloid A to different therapies in early rheumatoid arthritis and its potential value as a disease activity biomarker","volume":"18","author":"Hwang","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"B218","doi-asserted-by":"publisher","first-page":"6016","DOI":"10.3748\/wjg.v23.i33.6016","article-title":"Dextran sodium sulfate colitis murine model: an indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis","volume":"23","author":"Eichele","year":"2017","journal-title":"World J Gastroenterol"},{"key":"B219","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41572-020-0156-2","article-title":"Crohn\u2019s disease","volume":"6","author":"Roda","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"B220","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3389\/fmed.2019.00251","article-title":"A combined set of four serum inflammatory biomarkers reliably predicts endoscopic disease activity in inflammatory bowel disease","volume":"6","author":"Bourgonje","year":"2019","journal-title":"Front Med (Lausanne)"},{"key":"B221","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1111\/j.1365-2362.1987.tb01143.x","article-title":"Serum amyloid A protein compared with C-reactive protein, alpha 1-antichymotrypsin and alpha 1-acid glycoprotein as a monitor of inflammatory bowel disease","volume":"17","author":"Chambers","year":"1987","journal-title":"Eur J Clin Invest"},{"key":"B222","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s12876-020-01229-8","article-title":"Serum amyloid A is a better predictive biomarker of mucosal healing than C-reactive protein in ulcerative colitis in clinical remission","volume":"20","author":"Wakai","year":"2020","journal-title":"BMC Gastroenterol"},{"key":"B223","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1093\/ibd\/izab253","article-title":"Effects of JAK1-preferential inhibitor filgotinib on circulating biomarkers and whole blood genes\/pathways of patients with moderately to severely active Crohn\u2019s disease","volume":"28","author":"Roblin","year":"2022","journal-title":"Inflamm Bowel Dis"},{"key":"B224","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/1471-230X-10-133","article-title":"Intestinal epithelial serum amyloid A modulates bacterial growth in vitro and pro-inflammatory responses in mouse experimental colitis","volume":"10","author":"Eckhardt","year":"2010","journal-title":"BMC Gastroenterol"},{"key":"B225","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1097\/MIB.0000000000000991","article-title":"Serum amyloid A as a surrogate marker for mucosal and histologic inflammation in patients with Crohn\u2019s disease","volume":"23","author":"Yarur","year":"2017","journal-title":"Inflamm Bowel Dis"},{"key":"B226","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/j.cgh.2020.05.026","article-title":"Low-Fat, high-fiber diet reduces markers of inflammation and dysbiosis and improves quality of life in patients with ulcerative colitis","volume":"19","author":"Fritsch","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"B227","doi-asserted-by":"publisher","first-page":"3572","DOI":"10.3748\/wjg.v25.i27.3572","article-title":"Mucosal healing progression after acute colitis in mice","volume":"25","author":"Vidal-Lletj\u00f3s","year":"2019","journal-title":"World J Gastroenterol"},{"key":"B228","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.3389\/fimmu.2018.01503","article-title":"Elevated expression of serum amyloid A 3 protects colon epithelium against acute injury through TLR2-dependent induction of neutrophil IL-22 expression in a mouse model of colitis","volume":"9","author":"Zhang","year":"2018","journal-title":"Front Immunol"},{"key":"B229","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.lfs.2013.01.028","article-title":"Efficacy of drugs used in the treatment of IBD and combinations thereof in acute DSS-induced colitis in mice","volume":"92","author":"Sann","year":"2013","journal-title":"Life Sci"},{"key":"B230","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.clnu.2012.05.016","article-title":"Spores from two distinct colony types of the strain Bacillus subtilis PB6 substantiate anti-inflammatory probiotic effects in mice","volume":"31","author":"Folign\u00e9","year":"2012","journal-title":"Clin Nutr"},{"key":"B231","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.crohns.2009.09.006","article-title":"Anti-colitis and -adhesion effects of daikenchuto via endogenous adrenomedullin enhancement in Crohn\u2019s disease mouse model","volume":"4","author":"Kono","year":"2010","journal-title":"J Crohns Colitis"},{"key":"B232","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/j.jcmgh.2021.06.016","article-title":"Serum amyloid A promotes inflammation-associated damage and tumorigenesis in a mouse model of colitis-associated cancer","volume":"12","author":"Davis","year":"2021","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B233","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1111\/j.1365-2362.1989.tb00236.x","article-title":"Murine tissue macrophages synthesize and secrete amyloid proteins different to amyloid A (AA)","volume":"19","author":"Ramadori","year":"1989","journal-title":"Eur J Clin Invest"},{"key":"B234","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.bbrc.2003.12.096","article-title":"IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system","volume":"314","author":"Hagihara","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"B235","doi-asserted-by":"publisher","first-page":"631414","DOI":"10.1155\/2008\/631414","article-title":"Comparison of C-reactive protein and serum amyloid a protein in septic shock patients","volume":"2008","author":"Cicarelli","year":"2008","journal-title":"Mediators Inflamm"},{"key":"B236","doi-asserted-by":"publisher","first-page":"4718","DOI":"10.1073\/pnas.78.8.4718","article-title":"Induction of hepatic synthesis of serum amyloid A protein and actin","volume":"78","author":"Morrow","year":"1981","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B237","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1124\/dmd.114.061317","article-title":"Establishment of a hepatocyte-kupffer cell coculture model for assessment of proinflammatory cytokine effects on metabolizing enzymes and drug transporters","volume":"43","author":"Nguyen","year":"2015","journal-title":"Drug Metab Dispos"},{"key":"B238","doi-asserted-by":"publisher","first-page":"8453","DOI":"10.1016\/S0021-9258(19)83933-9","article-title":"Transcriptional regulation of serum amyloid A gene expression","volume":"261","author":"Lowell","year":"1986","journal-title":"J Biol Chem"},{"key":"B239","doi-asserted-by":"publisher","first-page":"e0150893","DOI":"10.1371\/journal.pone.0150893","article-title":"Serum amyloid A induces inflammation, proliferation and cell death in activated hepatic stellate cells","volume":"11","author":"Siegmund","year":"2016","journal-title":"PLoS One"},{"key":"B240","doi-asserted-by":"publisher","first-page":"25624","DOI":"10.1016\/S0021-9258(19)74435-4","article-title":"The role of NF-kappa B and NF-IL6 transactivating factors in the synergistic activation of human serum amyloid A gene expression by interleukin-1 and interleukin-6","volume":"268","author":"Betts","year":"1993","journal-title":"J Biol Chem"},{"key":"B241","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.atherosclerosis.2009.05.007","article-title":"Serum amyloid A induction of cytokines in monocytes\/macrophages and lymphocytes","volume":"207","author":"Song","year":"2009","journal-title":"Atherosclerosis"},{"key":"B242","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1038\/ijo.2011.193","article-title":"Serum amyloid A is a growth factor for 3T3-L1 adipocytes, inhibits differentiation and promotes insulin resistance","volume":"36","author":"Filippin-Monteiro","year":"2012","journal-title":"Int J Obes (Lond)"},{"key":"B243","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1038\/oby.2011.176","article-title":"Serum amyloid A induces lipolysis by downregulating perilipin through ERK1\/2 and PKA signaling pathways","volume":"19","author":"Liu","year":"2011","journal-title":"Obesity (Silver Spring)"},{"key":"B244","doi-asserted-by":"publisher","first-page":"703370","DOI":"10.3389\/fphys.2021.703370","article-title":"Mechanism-based biomarker prediction for low-grade inflammation in liver and adipose tissue","volume":"12","author":"van Bilsen","year":"2021","journal-title":"Front Physiol"},{"key":"B245","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1002\/jcb.21782","article-title":"The adipokine SAA3 is induced by interleukin-1beta in mouse adipocytes","volume":"104","author":"Sommer","year":"2008","journal-title":"J Cell Biochem"},{"key":"B246","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1177\/1753425910393370","article-title":"Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: potential link with metabolic complications","volume":"18","author":"Nakarai","year":"2012","journal-title":"Innate Immun"},{"key":"B247","doi-asserted-by":"publisher","first-page":"55","DOI":"10.4161\/gmic.1.1.10514","article-title":"Microbial regulation of SAA3 expression in mouse colon and adipose tissue","volume":"1","author":"Reigstad","year":"2010","journal-title":"Gut Microbes"},{"key":"B248","doi-asserted-by":"publisher","first-page":"399","DOI":"10.4049\/jimmunol.169.1.399","article-title":"Differential glucocorticoid enhancement of the cytokine-driven transcriptional activation of the human acute phase serum amyloid A genes, SAA1 and SAA2","volume":"169","author":"Thorn","year":"2002","journal-title":"J Immunol"},{"key":"B249","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/j.chom.2021.06.014","article-title":"Maternal cecal microbiota transfer rescues early-life antibiotic-induced enhancement of type 1 diabetes in mice","volume":"29","author":"Zhang","year":"2021","journal-title":"Cell Host Microbe"},{"key":"B250","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/s0022-1759(96)00220-7","article-title":"Use of the acute phase serum amyloid A2 (SAA2) gene promoter in the analysis of pro- and anti-inflammatory mediators: differential kinetics of SAA2 promoter induction by IL-1 beta and TNF-alpha compared to IL-6","volume":"203","author":"Uhlar","year":"1997","journal-title":"J Immunol Methods"},{"key":"B251","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.febslet.2004.05.072","article-title":"Lipopolysaccharide signaling induces serum amyloid A (SAA) synthesis in human hepatocytes in vitro","volume":"569","author":"Migita","year":"2004","journal-title":"FEBS Lett"},{"key":"B252","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/1043-4666(91)90041-b","article-title":"Constitutive and NF-kappa B-like proteins in the regulation of the serum amyloid A gene by interleukin 1","volume":"3","author":"Edbrooke","year":"1991","journal-title":"Cytokine"},{"key":"B253","doi-asserted-by":"publisher","first-page":"e34031","DOI":"10.1371\/journal.pone.0034031","article-title":"The acute phase protein Serum amyloid A induces lipolysis and inflammation in human adipocytes through distinct pathways","volume":"7","author":"Faty","year":"2012","journal-title":"PLoS One"},{"key":"B254","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.jnutbio.2009.01.004","article-title":"Docosahexaenoic acid regulates serum amyloid A protein to promote lipolysis through down regulation of perilipin","volume":"21","author":"Wang","year":"2010","journal-title":"J Nutr Biochem"},{"key":"B255","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/978-1-0716-2087-8_19","article-title":"Analysis of single-cell\/nucleus transcriptome data in adipose tissue","volume":"2448","author":"Sun","year":"2022","journal-title":"Methods Mol Biol"},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21134773","article-title":"The impact of single-cell genomics on adipose tissue research","volume":"21","author":"Deutsch","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B257","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1016\/j.cmet.2021.10.012","article-title":"Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin","volume":"33","author":"B\u00e4ckdahl","year":"2021","journal-title":"Cell Metab"},{"key":"B258","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1530\/EJE-11-0431","article-title":"RBP4: a controversial adipokine","volume":"165","author":"Kotnik","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"B259","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1194\/jlr.R094060","article-title":"Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication","volume":"60","author":"Funcke","year":"2019","journal-title":"J Lipid Res"},{"key":"B260","doi-asserted-by":"publisher","DOI":"10.3390\/cells8070727","article-title":"Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis","volume":"8","author":"Doyle","year":"2019","journal-title":"Cells"},{"key":"B261","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1080\/21623945.2021.1983242","article-title":"Composition, isolation, identification and function of adipose tissue-derived exosomes","volume":"10","author":"Zhao","year":"2021","journal-title":"Adipocyte"},{"key":"B262","doi-asserted-by":"publisher","first-page":"140172","DOI":"10.1016\/j.bbapap.2018.11.009","article-title":"Exosomal proteins constitute an essential part of the human adipose tissue secretome","volume":"1867","author":"Hartwig","year":"2019","journal-title":"Biochim Biophys Acta Proteins Proteom"},{"key":"B263","doi-asserted-by":"publisher","first-page":"4051","DOI":"10.1158\/0008-5472.CAN-16-0651","article-title":"Adipocyte exosomes promote melanoma aggressiveness through fatty acid oxidation: a novel mechanism linking obesity and cancer","volume":"76","author":"Lazar","year":"2016","journal-title":"Cancer Res"},{"key":"B264","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1007\/s00109-016-1446-8","article-title":"Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress","volume":"94","author":"Eguchi","year":"2016","journal-title":"J Mol Med (Berl)"},{"key":"B265","doi-asserted-by":"publisher","first-page":"351","DOI":"10.7150\/ijbs.28522","article-title":"Exosomal transfer of obesity adipose tissue for decreased miR-141-3p mediate insulin resistance of hepatocytes","volume":"15","author":"Dang","year":"2019","journal-title":"Int J Biol Sci"},{"key":"B266","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.mam.2017.11.010","article-title":"Extracellular vesicles in obesity and diabetes mellitus","volume":"60","author":"Pardo","year":"2018","journal-title":"Mol Aspects Med"},{"key":"B267","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fcvm.2020.00010","article-title":"Monocytes and macrophages as protagonists in vascular complications of diabetes","volume":"7","author":"Kanter","year":"2020","journal-title":"Front Cardiovasc Med"},{"key":"B268","first-page":"778","article-title":"Serum amyloid A changes high density lipoprotein\u2019s cellular affinity. A clue to serum amyloid A\u2019s principal function","volume":"66","author":"Kisilevsky","year":"1992","journal-title":"Lab Invest"},{"key":"B269","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1111\/j.1365-2249.1997.287-c31178.x","article-title":"Serum amyloid A gene expression in rabbit, mink and mouse","volume":"107","author":"Marhaug","year":"1997","journal-title":"Clin Exp Immunol"},{"key":"B270","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1369\/jhc.5A6645.2005","article-title":"Expression of serum amyloid A, in normal, dysplastic, and neoplastic human colonic mucosa: implication for a role in colonic tumorigenesis","volume":"54","author":"Gutfeld","year":"2006","journal-title":"J Histochem Cytochem"},{"key":"B271","doi-asserted-by":"publisher","first-page":"e5842","DOI":"10.1371\/journal.pone.0005842","article-title":"Regulation of serum amyloid A3 (SAA3) in mouse colonic epithelium and adipose tissue by the intestinal microbiota","volume":"4","author":"Reigstad","year":"2009","journal-title":"PLoS One"},{"key":"B272","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.cell.2015.08.061","article-title":"An IL-23R\/IL-22 circuit regulates epithelial Serum amyloid A to promote local effector Th17 responses","volume":"163","author":"Sano","year":"2015","journal-title":"Cell"},{"key":"B273","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/s0005-2760(96)00143-9","article-title":"LPS And cytokines regulate extra hepatic mRNA levels of apolipoproteins during the acute phase response in Syrian hamsters","volume":"1344","author":"Hardard\u00f3ttir","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"B274","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/s41586-019-1237-9","article-title":"Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases","volume":"569","author":"Lloyd-Price","year":"2019","journal-title":"Nature"},{"key":"B275","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1136\/gutjnl-2011-301104","article-title":"Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88","volume":"61","author":"Larsson","year":"2012","journal-title":"Gut"},{"key":"B276","doi-asserted-by":"publisher","first-page":"16140","DOI":"10.1038\/nmicrobiol.2016.140","article-title":"Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice","volume":"1","author":"Livanos","year":"2016","journal-title":"Nat Microbiol"},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.37816","article-title":"Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity","volume":"7","author":"Zhang","year":"2018","journal-title":"Elife"},{"key":"B278","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033","article-title":"Induction of intestinal Th17 cells by segmented filamentous bacteria","volume":"139","author":"Ivanov","year":"2009","journal-title":"Cell"},{"key":"B279","doi-asserted-by":"publisher","first-page":"e1007381","DOI":"10.1371\/journal.ppat.1007381","article-title":"Intestinal Serum amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization","volume":"15","author":"Murdoch","year":"2019","journal-title":"PLoS Pathog"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201745517","article-title":"Serum amyloid A promotes LPS clearance and suppresses LPS-induced inflammation and tissue injury","author":"Cheng","year":"2018","journal-title":"EMBO Rep"},{"key":"B281","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.4049\/jimmunol.1700470","article-title":"Suppression of lipopolysaccharide-induced inflammatory response by fragments from Serum amyloid A","volume":"199","author":"Zhou","year":"2017","journal-title":"J Immunol"},{"key":"B282","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12915-017-0352-z","article-title":"The landscape of sex-differential transcriptome and its consequent selection in human adults","volume":"15","author":"Gershoni","year":"2017","journal-title":"BMC Biol"},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba3066","article-title":"The impact of sex on gene expression across human tissues","volume":"369","author":"Oliva","year":"2020","journal-title":"Science"},{"key":"B284","doi-asserted-by":"publisher","first-page":"107795","DOI":"10.1016\/j.celrep.2020.107795","article-title":"Sex differences in gene expression and regulatory networks across 29 human tissues","volume":"31","author":"Lopes-Ramos","year":"2020","journal-title":"Cell Rep"},{"key":"B285","doi-asserted-by":"publisher","first-page":"18758","DOI":"10.1038\/s41598-021-98059-9","article-title":"Sex-dependent gene co-expression in the human body","volume":"11","author":"Hartman","year":"2021","journal-title":"Sci Rep"},{"key":"B286","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1471-2172-7-2","article-title":"Sexual dimorphism in immune response genes as a function of puberty","volume":"7","author":"Lamason","year":"2006","journal-title":"BMC Immunol"},{"key":"B287","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/j.1365-2796.2009.02120.x","article-title":"Serum amyloid A is independently associated with metabolic risk factors but not with early atherosclerosis: the cardiovascular risk in young finns study","volume":"266","author":"Jylh\u00e4v\u00e4","year":"2009","journal-title":"J Intern Med"},{"key":"B288","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00301-17","article-title":"Feminization of male mouse liver by persistent growth hormone stimulation: activation of sex-biased transcriptional networks and dynamic changes in chromatin states","volume":"37","author":"Lau-Corona","year":"2017","journal-title":"Mol Cell Biol"},{"key":"B289","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1055\/s-2002-38265","article-title":"Adipose tissue intracrinology: potential importance of local androgen\/estrogen metabolism in the regulation of adiposity","volume":"34","author":"B\u00e9langer","year":"2002","journal-title":"Horm Metab Res"},{"key":"B290","doi-asserted-by":"publisher","first-page":"929246","DOI":"10.1155\/2015\/929246","article-title":"Sexual dimorphisms of adrenal steroids, sex hormones, and immunological biomarkers and possible risk factors for developing rheumatoid arthritis","volume":"2015","author":"Masi","year":"2015","journal-title":"Int J Endocrinol"},{"key":"B291","doi-asserted-by":"publisher","first-page":"e164","DOI":"10.1161\/01.ATV.0000140198.16664.8e","article-title":"Contrasting effects of oral versus transdermal estrogen on serum amyloid A (SAA) and high-density lipoprotein-SAA in postmenopausal women","volume":"24","author":"Abbas","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B292","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.1538-7836.2005.01690.x","article-title":"Treatment with combined oral contraceptives induces a rise in serum C-reactive protein in the absence of a general inflammatory response","volume":"4","author":"van Rooijen","year":"2006","journal-title":"J Thromb Haemost"},{"key":"B293","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1161\/hc1202.105945","article-title":"Effect of medroxyprogesterone acetate on vascular inflammatory markers in postmenopausal women receiving estrogen","volume":"105","author":"Wakatsuki","year":"2002","journal-title":"Circulation"},{"key":"B294","doi-asserted-by":"publisher","first-page":"13250","DOI":"10.1074\/jbc.M114.634568","article-title":"Differences in hematopoietic stem cells contribute to sexually dimorphic inflammatory responses to high fat diet-induced obesity","volume":"290","author":"Singer","year":"2015","journal-title":"J Biol Chem"},{"key":"B295","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11185360","article-title":"Tocilizumab for the treatment of familial Mediterranean fever-A randomized, double-blind, placebo-controlled phase II study","volume":"11","author":"Henes","year":"2022","journal-title":"J Clin Med"},{"key":"B296","doi-asserted-by":"publisher","first-page":"610","DOI":"10.3109\/14397595.2014.908810","article-title":"Successful treatment with humanized anti-interleukin-6 receptor antibody (tocilizumab) in a case of AA amyloidosis complicated by familial Mediterranean fever","volume":"26","author":"Hamanoue","year":"2016","journal-title":"Mod Rheumatol"},{"key":"B297","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1080\/24725625.2020.1739193","article-title":"Long term administration of tocilizumab improves renal amyloid A (AA) amyloidosis deposition in Familial Mediterranean fever","volume":"4","author":"Inui","year":"2020","journal-title":"Mod Rheumatol Case Rep"},{"key":"B298","doi-asserted-by":"publisher","first-page":"232","DOI":"10.5414\/CN109273","article-title":"Tocilizumab histologically improved AA renal amyloidosis in a patient with multicentric castleman disease: a case report","volume":"90","author":"Yamada","year":"2018","journal-title":"Clin Nephrol"},{"key":"B299","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1002\/art.22118","article-title":"Successful use of a humanized anti-interleukin-6 receptor antibody, tocilizumab, to treat amyloid A amyloidosis complicating juvenile idiopathic arthritis","volume":"54","author":"Okuda","year":"2006","journal-title":"Arthritis Rheum"},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57101049","article-title":"Amyloidosis and glomerular diseases in familial Mediterranean fever","volume":"57","author":"Siligato","year":"2021","journal-title":"Medicina (Kaunas)"},{"key":"B301","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10787-020-00753-z","article-title":"Effect of canakinumab on clinical and biochemical parameters in acute gouty arthritis: a meta-analysis","volume":"29","author":"Jena","year":"2021","journal-title":"Inflammopharmacology"},{"key":"B302","doi-asserted-by":"publisher","first-page":"1135695","DOI":"10.3389\/fmed.2023.1135695","article-title":"Serum amyloid A-A potential therapeutic target for hyper-inflammatory syndrome associated with COVID-19","volume":"10","author":"Almusalami","year":"2023","journal-title":"Front Med (Lausanne)"},{"key":"B303","doi-asserted-by":"publisher","first-page":"7172","DOI":"10.1074\/jbc.274.11.7172","article-title":"The heparin\/heparan sulfate-binding site on apo-serum amyloid A. Implications for the therapeutic intervention of amyloidosis","volume":"274","author":"Ancsin","year":"1999","journal-title":"J Biol Chem"},{"key":"B304","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1194\/jlr.M500191-JLR200","article-title":"Peptides derived from serum amyloid A prevent, and reverse, aortic lipid lesions in apoE-\/- mice","volume":"46","author":"Tam","year":"2005","journal-title":"J Lipid Res"},{"key":"B305","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1517\/14656566.9.12.2175","article-title":"Eprodisate in amyloid A amyloidosis: a novel therapeutic approach?","volume":"9","author":"Manenti","year":"2008","journal-title":"Expert Opin Pharmacother"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2023.1197432\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T01:55:48Z","timestamp":1686794148000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2023.1197432\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,15]]},"references-count":305,"alternative-id":["10.3389\/fcvm.2023.1197432"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2023.1197432","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,15]]},"article-number":"1197432"}}