{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:34:43Z","timestamp":1787168083143,"version":"build-2736575974"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>LACHT (Lung Agenesis, Congenital Heart, and Thumb anomalies) syndrome is an extremely rare congenital anomaly and presents significant challenges in adults due to its poor survival rates. Herein, we report a case of late diagnosis and successful transcatheter treatment of aortic coarctation in a 58-year-old male patient with LACHT syndrome, medically resistant arterial hypertension, and left lung agenesis. Baseline CT angiography showed isthmic aortic coarctation and left lung agenesis, with compensatory right pulmonary artery and vein thickenings. The patient underwent balloon dilation and subsequent implantation of a covered NuMED 45\u2005mm 8-ZIG CP stent with satisfactory outcomes. The pressure gradient decreased from 43 to 23\u2005mmHg. The arterial pressures normalized during the follow-up with fewer medications. Genetic testing identified a heterozygous mutation (c.6583C\u2009&amp;gt;\u2009T) in the FBN2, supporting the diagnosis of variant Marfan syndrome.<\/jats:p>","DOI":"10.3389\/fcvm.2023.1239624","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T02:28:51Z","timestamp":1701311331000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Transcatheter treatment of aortic coarctation in a 58-year-old patient with LACHT syndrome and left lung agenesis"],"prefix":"10.3389","volume":"10","author":[{"given":"Qingxian","family":"Tu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanqu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujia","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaji","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianfeng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1002\/ppul.25754","article-title":"Horseshoe lung in LACHT syndrome (Mardini-Nyhan association): a plethora of anomalies","volume":"57","author":"Ramegowda","year":"2022","journal-title":"Pediatr Pulmonol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1002\/ajmg.a.61746","article-title":"LACHT syndrome (Mardini-Nyhan association) with tracheal stenosis in a Thai newborn","volume":"182","author":"Rojnueangnit","year":"2020","journal-title":"Am J Med Genet A"},{"key":"B3","doi-asserted-by":"publisher","first-page":"781","DOI":"10.4067\/s0370-41062017000600781","article-title":"LACHT association with hypoplasia of the upper airway. 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