{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:43:21Z","timestamp":1791315801463,"version":"4.3.1"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hypertrophic cardiomyopathy (HCM) is a serious hereditary cardiomyopathy. It is characterized morphologically by an increased left ventricular wall thickness and mass and functionally by enhanced global chamber function and myocellular contractility, diastolic dysfunction, and myocardial fibrosis development. Typically, patients with HCM experience atrial fibrillation (AF), syncope, and ventricular fibrillation (VF), causing severe symptoms and cardiac arrest. In contrast, sinoatrial node (SAN) arrest in the setting of HCM is uncommon. In particular, during VF, it has not been described so far.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case summary<\/jats:title><jats:p>In this study, we report an 18-year-old woman patient with sudden cardiac arrest due to VF and successful cardiopulmonary resuscitation as the first clinical manifestation of non-obstructive HCM. Subsequently, a subcutaneous implantable cardioverter-defibrillator (ICD) was implanted for secondary VF prophylaxis. However, additional episodes of VF occurred. During these, device interrogation revealed a combined occurrence of VF, bradycardia, and SAN arrest, requiring a device exchange into a dual-chamber ICD. A heterozygous, pathogenic variant of the <jats:italic>MYH7<\/jats:italic> gene (c.2155C&amp;gt;T; p.Arg719Trp) was identified as causative for HCM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>First published in 1994, the particular <jats:italic>MYH7<\/jats:italic> variant (p.Arg719Trp) was described in HCM patients with a high incidence of premature cardiac death and a reduced life expectancy. Electrophysiological studies on HCM patients are mainly performed to treat AF and ventricular tachycardia. Further extraordinary arrhythmic phenotypes were reported only in a few HCM patients. Taken together, the present case with documented co-existing VF and SAN arrest is rare and also emphasizes addressing the presence of SAN arrest (in particular, during VF episodes) in HCM patients when a distinct ICD device is considered for implantation.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2023.1240189","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T13:45:24Z","timestamp":1699019124000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Hypertrophic cardiomyopathy with recurrent episodes of ventricular fibrillation and concurrent sinus arrest"],"prefix":"10.3389","volume":"10","author":[{"given":"Jassin","family":"Hamidi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Dittmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Schulze-Bahr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"E16","DOI":"10.1002\/clc.20520","article-title":"A novel mutation of the beta myosin heavy chain gene responsible for familial hypertrophic cardiomyopathy","volume":"32","author":"Wang","year":"2009","journal-title":"Clin Cardiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s12872-021-01927-5","article-title":"Diagnostic yield of genetic testing in a heterogeneous cohort of 1376 HCM patients","volume":"21","author":"Hathaway","year":"2021","journal-title":"BMC Cardiovasc Disord"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cm.10014","article-title":"The myosin power stroke","volume":"51","author":"Tyska","year":"2002","journal-title":"Cell Motil Cytoskelet"},{"key":"B4","first-page":"26","article-title":"Update on sick sinus syndrome, a cardiac disorder of aging","volume":"45","author":"Rodriguez","year":"1990","journal-title":"Geriatrics"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1016\/j.jacc.2018.10.044","article-title":"2018 ACC\/AHA\/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: a report of the American College of Cardiology\/American Heart Association task force on clinical practice guidelines and the Heart Rhythm Society","volume":"74","author":"Kusumoto","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.ccep.2018.02.002","article-title":"Sick sinus syndrome","volume":"10","author":"De Ponti","year":"2018","journal-title":"Card Electrophysiol Clin"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2160","DOI":"10.1001\/jama.1983.03340160046030","article-title":"Arrhythmias associated with sinus node dysfunction. 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