{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:43:26Z","timestamp":1790718206137,"version":"4.1.0"},"reference-count":126,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>For a long time, cardiovascular clinicians have focused their research on coronary atherosclerotic cardiovascular disease and acute myocardial infarction due to their high morbidity, high mortality, high disability rate, and limited treatment options. Despite the continuous optimization of the therapeutic methods and pharmacological therapies for myocardial ischemia\u2013reperfusion, the incidence rate of heart failure continues to increase year by year. This situation is speculated to be caused by the current therapies, such as reperfusion therapy after ischemic injury, drugs, rehabilitation, and other traditional treatments, that do not directly target the infarcted myocardium. Consequently, these therapies cannot fundamentally solve the problems of myocardial pathological remodeling and the reduction of cardiac function after myocardial infarction, allowing for the progression of heart failure after myocardial infarction. Coupled with the decline in mortality caused by acute myocardial infarction in recent years, this combination leads to an increase in the incidence of heart failure. As a new promising therapy rising at the beginning of the twenty-first century, cardiac regenerative medicine provides a new choice and hope for the recovery of cardiac function and the prevention and treatment of heart failure after myocardial infarction. In the past two decades, regeneration engineering researchers have explored and summarized the elements, such as cells, scaffolds, and cytokines, required for myocardial regeneration from all aspects and various levels day and night, paving the way for our later scholars to carry out relevant research and also putting forward the current problems and directions for us. Here, we describe the advantages and challenges of cardiac tissue engineering, a contemporary innovative therapy after myocardial infarction, to provide a reference for clinical treatment.<\/jats:p>","DOI":"10.3389\/fcvm.2023.1251669","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T15:25:39Z","timestamp":1696433139000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["New treatment methods for myocardial infarction"],"prefix":"10.3389","volume":"10","author":[{"given":"Bingbing","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenmin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.1016\/j.jacc.2019.04.036","article-title":"Epidemiology of cardiovascular disease in China and opportunities for improvement: JACC international","volume":"73","author":"Du","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1056\/NEJM200106073442303","article-title":"Evidence that human cardiac myocytes divide after myocardial infarction","volume":"344","author":"Beltrami","year":"2001","journal-title":"N Engl J Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1126\/science.1164680","article-title":"Evidence for cardiomyocyte renewal in humans","volume":"324","author":"Bergmann","year":"2009","journal-title":"Science"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1126\/science.1200708","article-title":"Transient regenerative potential of the neonatal mouse heart","volume":"331","author":"Porrello","year":"2011","journal-title":"Science"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2798","DOI":"10.1161\/CIRCULATIONAHA.117.031542","article-title":"Early regenerative capacity in the porcine heart","volume":"138","author":"Ye","year":"2018","journal-title":"Circulation"},{"key":"B6","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/nature20173","article-title":"Hypoxia induces heart regeneration in adult mice","volume":"541","author":"Nakada","year":"2017","journal-title":"Nature"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1038\/s41418-020-0492-5","article-title":"Targeting LncDACH1 promotes cardiac repair and regeneration after myocardium infarction","volume":"27","author":"Cai","year":"2020","journal-title":"Cell Death Differ"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1152\/japplphysiol.00328.2017","article-title":"Hypoxia-induced myocardial regeneration","volume":"123","author":"Kimura","year":"2017","journal-title":"J Appl Physiol (1985)"},{"key":"B9","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1161\/CIRCRESAHA.115.307017","article-title":"Functional recovery of a human neonatal heart after severe myocardial infarction","volume":"118","author":"Haubner","year":"2016","journal-title":"Circ Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1001\/jamacardio.2016.2225","article-title":"Adult stem cell therapy and heart failure, 2000 to 2016: a systematic review","volume":"1","author":"Nguyen","year":"2016","journal-title":"JAMA Cardiol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. 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