{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:37:00Z","timestamp":1793738220543,"version":"4.6.1"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Heart transplantation (HTx) represents the current best surgical treatment for patients affected by end-stage heart failure. However, with the improvement of medical and interventional therapies, the population of HTx candidates is increasingly old and at high-risk for mortality and complications. Moreover, the use of \u201cextended donor criteria\u201d to deal with the shortage of donors could increase the risk of worse outcomes after HTx. In this setting, the strategy of donor organ preservation could significantly affect HTx results. The most widely used technique for donor organ preservation is static cold storage in ice. New techniques that are clinically being used for donor heart preservation include static controlled hypothermia and machine perfusion (MP) systems. Controlled hypothermia allows for a monitored cold storage between 4\u00b0C and 8\u00b0C. This simple technique seems to better preserve the donor heart when compared to ice, probably avoiding tissue injury due to sub-zero \u00b0C temperatures. MP platforms are divided in normothermic and hypothermic, and continuously perfuse the donor heart, reducing ischemic time, a well-known independent risk factor for mortality after HTx. Also, normothermic MP permits to evaluate marginal donor grafts, and could represent a safe and effective technique to expand the available donor pool. However, despite the increasing number of donor hearts preserved with these new approaches, whether these techniques could be considered superior to traditional CS still represents a matter of debate. The aim of this review is to summarize and critically assess the available clinical data on donor heart preservation strategies employed for HTx.<\/jats:p>","DOI":"10.3389\/fcvm.2023.1253579","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T16:43:29Z","timestamp":1691772209000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Graft preservation in heart transplantation: current approaches"],"prefix":"10.3389","volume":"10","author":[{"given":"Andrea","family":"Lechiancole","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Sponga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Benedetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Semeraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Guzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Daffarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Meneguzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Nalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Piani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Bressan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugolino","family":"Livi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Vendramin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.healun.2014.02.027","article-title":"Report from a consensus conference on primary graft dysfunction after cardiac transplantation","volume":"33","author":"Kobashigawa","year":"2014","journal-title":"J Heart Lung Transplant"},{"key":"B2","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1007\/s10741-019-09794-1","article-title":"Primary graft dysfunction after heart transplantation: a thorn amongst the roses","volume":"24","author":"Singh","year":"2019","journal-title":"Heart Fail Rev"},{"key":"B3","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/ejcts\/ezw271","article-title":"Application of the international society for heart and lung transplantation (ISHLT) criteria for primary graft dysfunction after cardiac transplantation: outcomes from a high-volume centre","volume":"51","author":"Squiers","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"B4","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1097\/TP.0000000000002220","article-title":"ISHLT primary graft dysfunction - incidence, risk factors, and outcome: a UK national study","volume":"103","author":"Avtaar Singh","year":"2019","journal-title":"Transplantation"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.healun.2017.07.019","article-title":"International society for heart and lung transplantation. 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