{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:00:11Z","timestamp":1791165611944,"version":"4.1.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Aortic aneurysm is a chronic arterial disease that can lead to aortic rupture, causing severe complications and life-threatening risks for patients, and it is one of the common causes of death among the elderly. Increasing evidence suggests that inflammation plays an important role in the progression of aortic aneurysm. However, there is a lack of literature-based quantitative analysis in this field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Up to March 30, 2023, we collected 3,993 articles related to aortic aneurysm and inflammation from the Web of Science Core Collection (WoSCC) database for bibliometric analysis. The collected literature data were subjected to visual analysis of regional distribution, institutions, authors, keywords, and other information using tools such as CiteSpace, VOSviewer, the R package \u201cbibliometric,\u201d and online platforms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of publications in this research field has been steadily increasing each year, with the United States and China being the main contributing countries. Harvard University in the United States emerged as the most active and influential research institution in this field. Jonathan Golledge and Peter Libby were identified as the authors with the highest publication output and academic impact, respectively. Researchers in this field tend to publish their findings in influential journals such as the Journal of Vascular Surgery and Arteriosclerosis Thrombosis and Vascular Biology. \u201cAbdominal aortic aneurysm,\u201d \u201cgiant cell arteritis,\u201d \u201carterial stiffness,\u201d and \u201csmooth muscle cells\u201d were identified as the hottest topics in the field of aortic aneurysm and inflammation. In terms of keyword co-occurrence analysis, \u201cClinical relevant studies of AA\u201c (red), \u201cInflammatory activation\u201d (green), \u201cInflammatory mechanisms related to pathogenesis\u201d (dark blue), \u201cCytokines\u201d (yellow), \u201cRisk factors\u201d (purple), and \u201cPathological changes in vascular wall\u201d (cyan) formed the major research framework in this field. \u201cInflammation-related pathogenesis\u201d and \u201cinflammation activation\u201d have emerged as recent hot research directions, with \u201cmonocytes,\u201d \u201cprogression,\u201d and \u201cproliferation\u201d being the prominent topics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provides a comprehensive analysis of the knowledge network framework and research hotspots in the field of aortic aneurysm and inflammation through a literature-based quantitative approach. It offers valuable insights to guide scholars in identifying meaningful research directions in this field.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2023.1260935","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T04:54:10Z","timestamp":1701665650000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Global research status analysis of the association between aortic aneurysm and inflammation: a bibliometric analysis from 1999 to 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