{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:09:52Z","timestamp":1758478192142,"version":"3.41.2"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Aneurysms in systemic arteries are rare, and little is known about their relationship with aortic aneurysms. In this study, we aimed to evaluate the prevalence of aortic aneurysms and dissections (AAD) in patients with other systemic vessel aneurysms and dissections (OVAD) and identify their potential risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross-sectional study used a nationwide representative cohort sample from the Korea National Health Insurance Service-National Sample Cohort database. We defined OVAD as systemic vessel aneurysms and dissections excluding intracranial and aortic dissections and aneurysms. With a total of 690 OVAD patients and 2,760 non-OVAD matched controls, we investigated the prevalence of AAD in patients with OVAD and potential risk factors for their concurrence using the <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> test and logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of AAD in patients with OVAD was 10.6% (73\/690) and 0.3% (9\/2,760) in patients with non-OVAD. The adjusted odds ratio (OR) for having concurrent AAD with OVAD was 37.56 (95% CI: 18.29\u201377.12, <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001) after stratification by sex, age, income, region of residence and after adjustment for hypertension, diabetes mellitus, dyslipidemia, and extent of disability. The adjusted ORs of AAD were significantly higher in females [adjusted OR\u2009=\u200947.63 (95% CI: 10.72\u2013211.55)], and individuals aged \u226560 years [adjusted OR\u2009=\u200928.18 (95% CI: 13.42\u201359.17)], as well as those without hypertension [adjusted OR\u2009=\u200995.44 (95% CI: 18.21\u2013500.23)], diabetes mellitus [adjusted OR\u2009=\u200946.39 (95% CI: 18.85\u2013114.17)], without dyslipidemia [adjusted OR\u2009=\u200960.99 (95% CI: 20.83\u2013178.56), <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001 for all]. The prevalence of AAD significantly differed by according to specific sites of OVAD in carotid artery, upper extremity artery, iliac artery, lower extremity artery, and splanchnic artery (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001 for all).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of AAD in patients with OVAD was 37.56 times higher than that in the matched population. We may approach aneurysms as systemic diseases and further investigations of pathophysiology would help to clarify the relationships between AAD and OVAD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2023.1266430","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T08:59:13Z","timestamp":1698051553000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence of aortic aneurysms and dissections in patients with systemic vessel aneurysms and dissections; matched case-control study using a national sample cohort"],"prefix":"10.3389","volume":"10","author":[{"given":"Jihye","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Cheol","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1161\/CIRCULATIONAHA.109.880724","article-title":"Site specificity of aneurysmal disease","volume":"121","author":"Norman","year":"2010","journal-title":"Circulation"},{"key":"B2","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s00701-006-1077-x","article-title":"Risk factors for the association of intracranial and aortic aneurysms","volume":"149","author":"Miyazawa","year":"2007","journal-title":"Acta Neurochir (Wien)"},{"key":"B3","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ejvs.2005.02.046","article-title":"Is assessment of popliteal artery diameter in patients undergoing screening for abdominal aortic aneurysms a worthwhile procedure","volume":"30","author":"Morris-Stiff","year":"2005","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"B4","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.ejvs.2020.10.002","article-title":"Systematic review of the co-prevalence of arterial aneurysms within the vasculature","volume":"61","author":"van Laarhoven","year":"2021","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"B5","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/bjs.1800830122","article-title":"Thoracic and thoracoabdominal aortic aneurysm and dissection: an investigation based on autopsy","volume":"83","author":"Svensjo","year":"1996","journal-title":"Br J Surg"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1002\/bjs.6063","article-title":"Nationwide study of the outcome of popliteal artery aneurysms treated surgically (Br J Surg 2007; 94: 970\u2013977)","volume":"94","author":"Oshin","year":"2007","journal-title":"Br J Surg"},{"key":"B7","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/S1474-4422(11)70109-0","article-title":"Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis","volume":"10","author":"Vlak","year":"2011","journal-title":"Lancet Neurol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1016\/S0140-6736(15)00128-2","article-title":"Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990\u20132013: a systematic analysis for the global burden of disease study 2013","volume":"386","author":"Forouzanfar","year":"2015","journal-title":"Lancet"},{"key":"B9","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1053\/ejvs.1999.0980","article-title":"Treatment of ruptured abdominal aortic aneurysm, a permanent challenge or a waste of resources? 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