{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:36:57Z","timestamp":1789763817216,"version":"4.0.1"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recently, heart failure (HF) and inflammatory bowel disease (IBD) have been considered to be related diseases with increasing incidence rates; both diseases are related to immunity. This study aims to analyze and identify immune-related gene (IRG) markers of HF and IBD through bioinformatics and machine learning (ML) methods and to explore their immune infiltration characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study used gene expressiondata (GSE120895, GSE21610, GSE4183) from the Gene Expression Omnibus (GEO) database to screen differentially expressed genes (DEGs) and compare them with IRGs from the ImmPort database to obtain differentially expressed immune-related genes (DIRGs). Functional enrichment analysis of IRGs was performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, three machine models and protein\u2013protein interactions (PPIs) were established to identify diagnostic biomarkers. The receiver operating characteristic (ROC) curves were applied to evaluate the diagnostic value of the candidate biomarkersin the validation set (GSE1145, GSE36807) and obtain their correlations with immune cells through the Spearman algorithm. Finally, the CIBERSORT algorithm was used to evaluate the immune cell infiltration of the two diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-four DIRGs were screened and GO and KEGG analysis results showed that these genes are mainly related to inflammatory and immune responses. CCL2, CXCR2 and S100A9 were identified as biomarkers.The immune correlation results indicated in both diseases that CCL2 is positively correlated with mast cell activation, CXCR2 is positively correlated with neutrophils and S100A9 is positively correlated with neutrophils and mast cell activation. Analysis of immune characteristics showed that macrophages M2, macrophages M0 and neutrophils were present in both diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CCL2, CXCR2 and S100A9 are promising biomarkers that will become potential immunogenetic biomarkers for diagnosing comorbidities of HF and IBD. macrophages M2, macrophages M0, neutrophil-mediated inflammation and immune regulation play important roles in the development of HF and IBD and may become diagnostic and therapeutic targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2023.1268675","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T07:56:11Z","timestamp":1700121371000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Identification CCL2,CXCR2,S100A9 of the immune-related gene markers and immune infiltration characteristics of inflammatory bowel disease and heart failure via bioinformatics analysis and machine learning"],"prefix":"10.3389","volume":"10","author":[{"given":"Xu","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e876","DOI":"10.1161\/CIR.0000000000001062","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","article-title":"Global burden of heart failure: a comprehensive and updated review of epidemiology","volume":"118","author":"Savarese","year":"2023","journal-title":"Cardiovasc Res"},{"key":"B3","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1161\/CIRCRESAHA.116.308030","article-title":"Chronic heart failure and inflammation: what do we really know?","volume":"119","author":"Dick","year":"2016","journal-title":"Circ Res"},{"key":"B4","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s10741-020-09987-z","article-title":"Pathogenesis of chronic heart failure: cardiovascular aging, risk factors, comorbidities, and disease modifiers","volume":"27","author":"Triposkiadis","year":"2022","journal-title":"Heart Fail Rev"},{"key":"B5","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1001\/jama.2023.2020","article-title":"Heart failure with preserved ejection fraction: a review","volume":"329","author":"Redfield","year":"2023","journal-title":"JAMA"},{"key":"B6","doi-asserted-by":"publisher","first-page":"100691","DOI":"10.1016\/j.cpcardiol.2020.100691","article-title":"Physiopathology and diagnosis of congestive heart failure: consolidated certainties and new perspectives","volume":"46","author":"La Franca","year":"2021","journal-title":"Curr Probl Cardiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/nrneph.2016.113","article-title":"Heart failure and kidney dysfunction: epidemiology, mechanisms and management","volume":"12","author":"Schefold","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1002\/ejhf.942","article-title":"Immune mechanisms in heart failure","volume":"19","author":"Zhang","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"B9","doi-asserted-by":"publisher","first-page":"732794","DOI":"10.3389\/fimmu.2021.732794","article-title":"Regulatory T cells in chronic heart failure","volume":"12","author":"Lu","year":"2021","journal-title":"Front Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"294","DOI":"10.12688\/f1000research.20805.1","article-title":"Ulcerative colitis: recent advances in the understanding of disease pathogenesis","volume":"9","author":"Porter","year":"2020","journal-title":"F1000Res"},{"key":"B11","doi-asserted-by":"publisher","first-page":"12445","DOI":"10.3390\/ijms232012445","article-title":"Etiology of IBD-is it still a mystery?","volume":"23","author":"Kofla-Dlubacz","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1002\/ueg2.12317","article-title":"Implications of the changing epidemiology of inflammatory bowel disease in a changing world","volume":"10","author":"Agrawal","year":"2022","journal-title":"United European Gastroenterol J"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1002\/ueg2.12350","article-title":"The epidemiology of inflammatory bowel disease in Asia and Asian immigrants to western countries","volume":"10","author":"Aniwan","year":"2022","journal-title":"United European Gastroenterol J"},{"key":"B14","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.mayocp.2018.09.013","article-title":"Mechanisms of disease: inflammatory bowel diseases","volume":"94","author":"Ramos","year":"2019","journal-title":"Mayo Clin Proc"},{"key":"B15","doi-asserted-by":"publisher","first-page":"7618","DOI":"10.3390\/ijms22147618","article-title":"Innate lymphoid cells in intestinal homeostasis and inflammatory bowel disease","volume":"22","author":"Saez","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B16","article-title":"Extraintestinal manifestations of inflammatory bowel disease","author":"Malik","year":"2023","journal-title":"StatPearls"},{"key":"B17","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/MEG.0000000000001648","article-title":"Incident heart failure is a predictor of adverse outcomes in inflammatory bowel disease","volume":"32","author":"Kumar","year":"2020","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/j.amjmed.2022.08.012","article-title":"Inflammatory bowel disease and cardiovascular diseases","volume":"135","author":"Chen","year":"2022","journal-title":"Am J Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.3390\/ijms24021526","article-title":"Pathophysiology of inflammatory bowel disease: innate immune system","volume":"24","author":"Saez","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1161\/CIRCULATIONAHA.119.041694","article-title":"Single-cell sequencing of mouse heart immune infiltrate in pressure overload-driven heart failure reveals extent of immune activation","volume":"140","author":"Martini","year":"2019","journal-title":"Circulation"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.3390\/ijms22062903","article-title":"Incorporating machine learning into established bioinformatics frameworks","volume":"22","author":"Auslander","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B22","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s12887-023-03896-4","article-title":"Bioinformatic analysis of underlying mechanisms of kawasaki disease via weighted gene correlation network analysis (WGCNA) and the least absolute shrinkage and selection operator method (LASSO) regression model","volume":"23","author":"Xie","year":"2023","journal-title":"BMC Pediatr"},{"key":"B23","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1471-2105-8-25","article-title":"Bias in random forest variable importance measures: illustrations, sources and a solution","volume":"8","author":"Strobl","year":"2007","journal-title":"BMC Bioinformatics"},{"key":"B24","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1186\/s12859-018-2451-4","article-title":"SVM-RFE: selection and visualization of the most relevant features through non-linear kernels","volume":"19","author":"Sanz","year":"2018","journal-title":"BMC Bioinformatics"},{"key":"B25","doi-asserted-by":"publisher","first-page":"6687096","DOI":"10.1155\/2021\/6687096","article-title":"NETosis as a pathogenic factor for heart failure","volume":"2021","author":"Ling","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"B26","article-title":"Inflammatory bowel disease","author":"McDowell","year":"2023","journal-title":"StatPearls"},{"key":"B27","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/s10557-020-07071-0","article-title":"Inflammatory cytokines and chemokines as therapeutic targets in heart failure","volume":"34","author":"Hanna","year":"2020","journal-title":"Cardiovasc Drugs Ther"},{"key":"B28","doi-asserted-by":"publisher","first-page":"4","DOI":"10.2174\/18755305MTAwENDE80","article-title":"Mini review on antimicrobial peptides, sources, mechanism and recent applications","volume":"27","author":"Boparai","year":"2020","journal-title":"Protein Pept Lett"},{"key":"B29","doi-asserted-by":"publisher","first-page":"7402","DOI":"10.3748\/wjg.v27.i43.7402","article-title":"Antimicrobial peptides and the gut microbiome in inflammatory bowel disease","volume":"27","author":"Gubatan","year":"2021","journal-title":"World J Gastroenterol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1038\/s41401-020-00580-6","article-title":"Interleukin-17 upregulation participates in the pathogenesis of heart failure in mice via NF-kappaB-dependent suppression of SERCA2a and Cav1.2 expression","volume":"42","author":"Xue","year":"2021","journal-title":"Acta Pharmacol Sin"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-021-07304-w","article-title":"MicroRNA-30a-5p promotes chronic heart failure in rats by targeting sirtuin-1 to activate the nuclear factor-kappaB\/NOD-like receptor 3 signaling pathway","author":"Wu","year":"2022","journal-title":"Cardiovasc Drugs Ther"},{"key":"B32","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1161\/CIRCULATIONAHA.119.042336","article-title":"SNO-MLP (S-Nitrosylation of muscle LIM protein) facilitates myocardial hypertrophy through TLR3 (toll-like receptor 3)-mediated RIP3 (receptor-interacting protein kinase 3) and NLRP3 (NOD-like receptor pyrin domain containing 3) inflammasome activation","volume":"141","author":"Tang","year":"2020","journal-title":"Circulation"},{"key":"B33","doi-asserted-by":"publisher","first-page":"102429","DOI":"10.1016\/j.autrev.2019.102429","article-title":"Critical role of interleukin (IL)-17 in inflammatory and immune disorders: an updated review of the evidence focusing in controversies","volume":"19","author":"G","year":"2020","journal-title":"Autoimmun Rev"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1136\/annrheumdis-2020-217927","article-title":"Paradoxical gastrointestinal effects of interleukin-17 blockers","volume":"79","author":"Fauny","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.it.2021.09.005","article-title":"RORgammat protein modifications and IL-17-mediated inflammation","volume":"42","author":"Kumar","year":"2021","journal-title":"Trends Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"107598","DOI":"10.1016\/j.intimp.2021.107598","article-title":"MCP-1: function, regulation, and involvement in disease","volume":"101","author":"Singh","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S1359-6101(99)00005-2","article-title":"The MCP\/eotaxin subfamily of CC chemokines","volume":"10","author":"Van Coillie","year":"1999","journal-title":"Cytokine Growth Factor Rev"},{"key":"B38","doi-asserted-by":"publisher","first-page":"9912","DOI":"10.1016\/S0021-9258(18)92905-4","article-title":"Alveolar macrophage-derived cytokines induce monocyte chemoattractant protein-1 expression from human pulmonary type II-like epithelial cells","volume":"266","author":"Standiford","year":"1991","journal-title":"J Biol Chem"},{"key":"B39","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1089\/jir.2008.0027","article-title":"Monocyte chemoattractant protein-1 (MCP-1): an overview","volume":"29","author":"Deshmane","year":"2009","journal-title":"J Interferon Cytokine Res"},{"key":"B40","doi-asserted-by":"publisher","first-page":"975367","DOI":"10.3389\/fimmu.2022.975367","article-title":"Role of the CCL2-CCR2 axis in cardiovascular disease: pathogenesis and clinical implications","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.cophys.2020.10.004","article-title":"Chemokines in cardiac fibrosis","volume":"19","author":"Li","year":"2021","journal-title":"Curr Opin Physiol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"e835","DOI":"10.1002\/iid3.835","article-title":"TFRC in cardiomyocytes promotes macrophage infiltration and activation during the process of heart failure through regulating Ccl2 expression mediated by hypoxia inducible factor-1alpha","volume":"11","author":"Pan","year":"2023","journal-title":"Immun Inflamm Dis"},{"key":"B43","doi-asserted-by":"publisher","first-page":"406","DOI":"10.3390\/antiox11020406","article-title":"Coriolus versicolor downregulates TLR4\/NF-kappaB signaling cascade in dinitrobenzenesulfonic acid-treated mice: a possible mechanism for the anti-colitis effect","volume":"11","author":"Impellizzeri","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.3390\/ijms23042168","article-title":"CXCR2 receptor: regulation of expression, signal transduction, and involvement in cancer","volume":"23","author":"Korbecki","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B45","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.bbcan.2019.01.005","article-title":"Potential roles and targeted therapy of the CXCLs\/CXCR2 axis in cancer and inflammatory diseases","volume":"1871","author":"Cheng","year":"2019","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"B46","doi-asserted-by":"publisher","first-page":"165551","DOI":"10.1016\/j.bbadis.2019.165551","article-title":"Chronic inhibition of chemokine receptor CXCR2 attenuates cardiac remodeling and dysfunction in spontaneously hypertensive rats","volume":"1865","author":"Zhang","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1093\/eurheartj\/ehy085","article-title":"CXCL1-CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltration","volume":"39","author":"Wang","year":"2018","journal-title":"Eur Heart J"},{"key":"B48","doi-asserted-by":"publisher","first-page":"896645","DOI":"10.3389\/fimmu.2022.896645","article-title":"Neutrophil infiltration characterized by upregulation of S100A8, S100A9, S100A12 and CXCR2 is associated with the co-occurrence of crohn\u2019s disease and peripheral artery disease","volume":"13","author":"Yao","year":"2022","journal-title":"Front Immunol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.1038\/s41467-021-22810-z","article-title":"Selection of a picomolar antibody that targets CXCR2-mediated neutrophil activation and alleviates EAE symptoms","volume":"12","author":"Shi","year":"2021","journal-title":"Nat Commun"},{"key":"B50","doi-asserted-by":"publisher","first-page":"113405","DOI":"10.1016\/j.yexcr.2022.113405","article-title":"S100a9 induces reactive oxygen species-dependent formation of neutrophil extracellular traps in abdominal sepsis","volume":"421","author":"Du","year":"2022","journal-title":"Exp Cell Res"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1161\/CIRCULATIONAHA.114.013789","article-title":"Myocardial hypertrophic preconditioning attenuates cardiomyocyte hypertrophy and slows progression to heart failure through upregulation of S100A8\/A9","volume":"131","author":"Wei","year":"2015","journal-title":"Circulation"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1093\/eurheartj\/ehz461","article-title":"Inhibition of pro-inflammatory myeloid cell responses by short-term S100A9 blockade improves cardiac function after myocardial infarction","volume":"40","author":"Marinkovic","year":"2019","journal-title":"Eur Heart J"},{"key":"B53","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ajg.2019.07.002","article-title":"The value of mRNA expression of S100A8 and S100A9 as blood-based biomarkers of inflammatory bowel disease","volume":"20","author":"Azramezani Kopi","year":"2019","journal-title":"Arab J Gastroenterol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1182\/blood.2021012295","article-title":"Neutrophils in acute inflammation: current concepts and translational implications","volume":"139","author":"Margraf","year":"2022","journal-title":"Blood"},{"key":"B55","doi-asserted-by":"publisher","first-page":"107424","DOI":"10.1016\/j.pharmthera.2019.107424","article-title":"Role of neutrophils in ischemic heart failure","volume":"205","author":"Kain","year":"2020","journal-title":"Pharmacol Ther"},{"key":"B56","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3390\/cells10010051","article-title":"Role of cardiac macrophages on cardiac inflammation, fibrosis and tissue repair","volume":"10","author":"Lafuse","year":"2020","journal-title":"Cells"},{"key":"B57","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3390\/ijms23010144","article-title":"Macrophage polarity and disease control","volume":"23","author":"Kadomoto","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B58","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s40824-022-00260-y","article-title":"M2-like macrophages transplantation protects against the doxorubicin-induced heart failure via mitochondrial transfer","volume":"26","author":"Liu","year":"2022","journal-title":"Biomater Res"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.3389\/fimmu.2018.02733","article-title":"Origin, differentiation, and function of intestinal macrophages","volume":"9","author":"Bain","year":"2018","journal-title":"Front Immunol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/s41575-019-0172-4","article-title":"Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD","volume":"16","author":"Na","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.ejphar.2017.09.044","article-title":"Impact of mast cells in mucosal immunity of intestinal inflammation: inhibitory effect of IL-37","volume":"818","author":"Conti","year":"2018","journal-title":"Eur J Pharmacol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1161\/01.ATV.0000174797.71708.97","article-title":"Mast cell tryptase in mast cell granules enhances MCP-1 and interleukin-8 production in human endothelial cells","volume":"25","author":"Kinoshita","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1080\/00365521.2016.1235224","article-title":"Neutrophils in ulcerative colitis: a review of selected biomarkers and their potential therapeutic implications","volume":"52","author":"Muthas","year":"2017","journal-title":"Scand J Gastroenterol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"708770","DOI":"10.3389\/fimmu.2021.708770","article-title":"Transcriptional profiling and functional analysis of N1\/N2 neutrophils reveal an immunomodulatory effect of S100A9-blockade on the pro-inflammatory N1 subpopulation","volume":"12","author":"Mihaila","year":"2021","journal-title":"Front Immunol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.7150\/thno.67174","article-title":"Overexpression of S100A9 in obesity impairs macrophage differentiation via TLR4-NFkB-signaling worsening inflammation and wound healing","volume":"12","author":"Franz","year":"2022","journal-title":"Theranostics"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2023.1268675\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T07:56:14Z","timestamp":1700121374000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2023.1268675\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,16]]},"references-count":65,"alternative-id":["10.3389\/fcvm.2023.1268675"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2023.1268675","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,16]]},"article-number":"1268675"}}