{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T21:18:51Z","timestamp":1778879931341,"version":"3.51.4"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of Guangdong","doi-asserted-by":"publisher","award":["2022A1515010157"],"award-info":[{"award-number":["2022A1515010157"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Anomalous papillary muscle (APM) insertion into the mitral valve leaflet is rare but clinically important in hypertrophic obstructive cardiomyopathy (HOCM). In this study, we report the detection rate of APM insertion into the mitral valve using preoperative imaging modalities and the surgical outcomes of the patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>By retrospectively reviewing the clinical records of patients with HOCM who underwent surgical treatment by a single operation group at our center from January 2020 to June 2023, patients with APM insertion into the mitral valve lea\ufb02et were identified. Baseline data, image characteristics, and surgical outcomes were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of APM insertion into the mitral valve lea\ufb02et was 5.1% (8\/157). The insertion site was located at A3 in six cases, which was more common than at A2 (<jats:italic>n\u2009<\/jats:italic>=<jats:italic>\u2009<\/jats:italic>2). Preoperative echocardiography was used to identify two patients (25%) with APM insertion. We observed a particular echocardiographic feature for APM in HOCM patients, which was noted as a \u201clip nevus sign\u201d, with a higher detection rate (62.5%). All patients successfully underwent septal myectomy with concomitant APM excision or mitral valve replacement via the transaortic (<jats:italic>n\u2009<\/jats:italic>=<jats:italic>\u2009<\/jats:italic>5) or transmitral (<jats:italic>n\u2009<\/jats:italic>=<jats:italic>\u2009<\/jats:italic>3) approach. The mean age was 49.0\u2009\u00b1\u200917.4 years and seven patients (87.5%) were female. Interventricular septum thickness (17.0\u2005mm vs. 13.3\u2005mm, <jats:italic>P\u2009<\/jats:italic>=<jats:italic>\u2009<\/jats:italic>0.012) and left ventricular outflow gradient (117.5\u2005mmHg vs. 7.5\u2005mmHg, <jats:italic>P\u2009<\/jats:italic>=<jats:italic>\u2009<\/jats:italic>0.012) were significantly decreased after surgery. Residual outflow obstruction, systolic anterior motion, and \u22653+ mitral regurgitation were negative. During the follow-up of 26.2\u2009\u00b1\u200912.2 months, there were no reported operations, adverse events, mitral regurgitation aggravations, recurrences of outflow obstruction, or instances of SAM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Papillary muscles inserted into the mitral valve lea\ufb02et are a subtype of subvalvular malformation in HOCM that requires surgical correction. The lip nevus sign on echocardiography is a characteristic of APM insertion in HOCM and may improve the preoperative detection rate. Adequate myectomy with anomalous papillary muscle excision has achieved good results in reducing the outflow gradient and eliminating mitral regurgitation, with good outcomes at short-to-intermediate follow-up.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2023.1292142","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T08:23:06Z","timestamp":1701850986000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Anomalous papillary muscle insertion into the mitral valve leaflet in hypertrophic obstructive cardiomyopathy: a lip nevus sign in 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