{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:40:36Z","timestamp":1790026836221,"version":"4.0.1"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Bicuspid aortic valve (BAV) is the most common congenital heart disease with an increased risk of infective endocarditis (IE). Few data are available on isolated native BAV-IE. The aim of this study was to compare patients with tricuspid aortic valve (TAV) IE and BAV-IE in terms of characteristics, management and prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>We included 728 consecutive patients with IE on isolated native aortic valve in 3 centres: Amiens and Marseille Hospitals in France and Salerno Hospital in Italy. We studied in hospital and long-term mortality before and after matching for age, sex and comorbidity index. Median follow-up was 67.2 [IQR: 19\u2013120] months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 728 patients, 123 (16.9%) had BAV. Compared with patients with TAV-IE, patients with BAV-IE were younger, had fewer co-morbidities and were more likely to be male. They presented more major neurological events and perivalvular complications (both <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). Early surgery (&amp;lt;30 days) was performed in 52% of BAV-IE cases vs. 42.8% for TAV-IE (<jats:italic>p<\/jats:italic>\u2009=\u20090.061). The 10-year survival rate was 74\u2009\u00b1\u20095% in BAV-IE patients compared with 66\u2009\u00b1\u20092% in TAV-IE patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.047). After propensity score matching (for age, gender and comorbidities), there was no difference in mortality between the two groups, with an estimated 10-year survival of 73\u2009\u00b1\u20095% vs. 76\u2009\u00b1\u20094% respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.91).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BAV is a frequent finding in patients with isolated aortic valve IE and is associated with more perivalvular complications and neurological events. The differences in survival with TAV-IE are probably related to the age and comorbidity differences between these two populations.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2023.1304957","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T13:44:57Z","timestamp":1702561497000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Characteristics and prognosis of isolated aortic valve infective endocarditis in patients with bicuspid aortic valves: a propensity matched study"],"prefix":"10.3389","volume":"10","author":[{"given":"Yohann","family":"Bohbot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyhan","family":"Denev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella M.","family":"Benvenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Philip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector I.","family":"Michelena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Citro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Habib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Tribouilloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3948","DOI":"10.1093\/eurheartj\/ehad193","article-title":"ESC scientific document group. 2023 ESC guidelines for the management of endocarditis","volume":"44","author":"Delgado","year":"2023","journal-title":"Eur Heart J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1086\/313646","article-title":"Bicuspid aortic valve: a silent danger: analysis of 50 cases of infective endocarditis","volume":"30","author":"Lamas","year":"2000","journal-title":"Clin Infect Dis"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1136\/hrt.2009.189050","article-title":"Clinical characteristics and outcome of infective endocarditis in adults with bicuspid aortic valves: a multicentre observational study","volume":"96","author":"Tribouilloy","year":"2010","journal-title":"Heart"},{"key":"B4","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.mayocp.2020.04.047","article-title":"Clinical outcomes of adults with bicuspid aortic valve: a European perspective","volume":"96","author":"Cheng","year":"2021","journal-title":"Mayo Clin 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Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2023.1304957\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T13:44:59Z","timestamp":1702561499000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2023.1304957\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,14]]},"references-count":9,"alternative-id":["10.3389\/fcvm.2023.1304957"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2023.1304957","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,14]]},"article-number":"1304957"}}