{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:40:08Z","timestamp":1787240408531,"version":"build-2736575974"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"\n Aim<\/jats:title>\n Patients with unstable angina pectoris (UAP) usually present anxiety or depression during percutaneous coronary intervention (PCI). This study sought to investigate the instant and short-term effects of acupuncture for anxiety and depression in UAP patients with PCI.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A total of 210 UAP patients who underwent PCI were recruited and randomly assigned (1:1:1) to acupuncture, placebo, or control groups. Enzyme-linked immunosorbent assay was used to detect the levels of fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), interleukin-6 (IL-6), high-sensitivity C-reactive protein (Hs-CRP), advanced oxidation protein products (AoPPs), and oxidized low-density lipoprotein (OX-LDL). Serial questionnaires with the Hamilton Anxiety (HAMA) scale and the Pittsburgh Sleep Quality Index were evaluated, and heart rate variability indicators were obtained.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Primary end-point: low frequency\/high frequency (HF) was lower in the electroacupuncture group (\n p<\/jats:italic>\n \u2009=\u20090.014), while standard deviation of normal-to-normal intervals, average standard deviation of normal-to-normal intervals, percentage of successive intervals that differ more than 50\u2005ms, and HF were increased with acupuncture (\n p<\/jats:italic>\n \u2009=\u20090.018,\n p<\/jats:italic>\n \u2009=\u20090.043,\n p<\/jats:italic>\n \u2009=\u20090.016, and\n p<\/jats:italic>\n \u2009=\u20090.002, respectively). Secondary end-point: significant improvements in anxiety levels (HAMA) were observed in the three groups (\n p<\/jats:italic>\n \u2009&lt;\u20090.001). The fasting insulin and HOMA-IR levels were similar between the control group and the acupuncture group (\n p<\/jats:italic>\n \u2009=\u20090.285 and\n p<\/jats:italic>\n \u2009=\u20090.165, respectively). The levels of IL-6 and AoPPs differed among the three groups (\n p<\/jats:italic>\n \u2009=\u20090.021 and\n p<\/jats:italic>\n \u2009&lt;\u20090.001, respectively). However, no significant differences were found in fasting plasma glucose, fasting c-peptide, Hs-CRP, and OX-LDL levels among the three groups (\n p<\/jats:italic>\n \u2009=\u20090.585,\n p<\/jats:italic>\n \u2009=\u20090.611,\n p<\/jats:italic>\n \u2009=\u20090.902, and\n p<\/jats:italic>\n \u2009=\u20090.756, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In this study, short-term acupuncture may potentially relieve clinical symptoms before PCI treatment.<\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n ClinicalTrials.gov<\/jats:ext-link>\n , identifier (NCT03789344).\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fcvm.2024.1173080","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T23:19:38Z","timestamp":1705619978000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Instant and short-term effects of acupuncture for 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