{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:47:23Z","timestamp":1783532843605,"version":"3.55.0"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Coronary heart disease (CHD) is representative of cardiovascular disease and the leading cause of death in humans. Previous studies have shown that kidney disease is associated with CHD, and current treatment options that can improve both cardiac and renal functions still have some limitations. The traditional Chinese medicine Bu-Shen-Huo-Xue granule (BSHXG) can promote blood rheology, inhibit platelet agglutination, and improve heart and kidney functions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a multicenter, randomized, double-blind, placebo-controlled clinical trial. A total of 210 participants will be randomized to the intervention group and the placebo group. The Guang\u2019anmen Hospital of China Academy of Chinese Medical Sciences is the leading center, and the Affiliated Hospital of Shandong University of Chinese Medicine and the First Affiliated Hospital of Guangzhou University of Chinese Medicine are the participating units. In addition to conventional pharmacotherapy for angina, the intervention group will receive BSHXG while the placebo group will receive BSHXG placebo. All participants will receive 2\u2005months of treatment with 6\u2005months of follow-up. The primary outcome is the efficacy of angina pectoris symptoms in CHD. Secondary outcomes are nitroglycerin arrest, ECG efficacy, Seattle Angina Questionnaire score, serology indicators, assessment of safety, and cardiovascular endpoint events. The transcriptome and metabolome will be used to screen biomarkers for diagnosis and efficacy evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This study aimed to evaluate the efficacy and safety of Bu-Shen-Huo-Xue granule in the treatment of coronary heart disease, and to evaluate the benefits to patients with coronary heart disease from both cardiac and renal indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p>This trial is approved by the Ethical Review Committee of the Guang\u2019anmen Hospital China Academy of Chinese Medical Sciences with the number 2022-224-KY-01, and has been registered on the <jats:ext-link>Chinese Clinical Trials Registry<\/jats:ext-link> with the number ChiCTR2300070977 on 27 April 2023.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2024.1293818","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T05:55:28Z","timestamp":1717480528000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and safety of the Chinese herbal medicine Bu-Shen-Huo-Xue granule for the treatment of coronary heart disease: study protocol for a multicenter, randomized, double-blinded, placebo-controlled clinical trial"],"prefix":"10.3389","volume":"11","author":[{"given":"Lanchun","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyuan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyang","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongcheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuli","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"B1","volume-title":"World Health Statistics 2019: Monitoring Health for the SDGs, Sustainable Development Goals","year":"2019"},{"key":"B2","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3969\/j.issn.1000-3614.2022.06.001","article-title":"Overview of Chinese cardiovascular health and disease report 2021","volume":"37","author":"Hu","year":"2022","journal-title":"Chin J Circ"},{"key":"B3","doi-asserted-by":"publisher","first-page":"5541228","DOI":"10.1155\/2021\/5541228","article-title":"The effectiveness and safety of Bushen Huoxue decoction on treating coronary heart disease: a meta-analysis","volume":"2021","author":"Liu","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"780431","DOI":"10.3389\/fgene.2021.780431","article-title":"Identification of two long non-coding RNAs AC010082.1 and AC011443.1 as biomarkers of coronary heart disease based on logistic stepwise regression prediction model","volume":"12","author":"Liu","year":"2021","journal-title":"Front Genet"},{"key":"B5","doi-asserted-by":"publisher","first-page":"920","DOI":"10.13288\/j.11-2166\/r.2007.10.029","article-title":"Study on the combination of angina syndrome and indications in coronary heart disease","volume":"48","author":"Wang","year":"2007","journal-title":"J Trad Chin Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"211","DOI":"10.3969\/j.issn.1006-3250.2008.03.024","article-title":"Study on the extraction and combination of angina syndrome elements in 1069 cases of coronary heart disease by entropy accumulation pile method in complex systems","volume":"3","author":"Wang","year":"2008","journal-title":"Chin J Basic Med Trad Chin Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.19540\/j.cnki.cjcmm.20201221.601","article-title":"Correlation between estrogen levels and kidney deficiency syndrome in coronary heart disease and the intervention effect of kidney-tonifying traditional Chinese medicine","volume":"46","author":"Liu","year":"2021","journal-title":"Chin J Trad Chin Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jclinepi.2010.03.004","article-title":"CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials","volume":"63","author":"Moher","year":"2010","journal-title":"J Clin Epidemiol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1001\/jamainternmed.2019.2407","article-title":"Acupuncture as adjunctive therapy for chronic stable angina: a randomized clinical trial","volume":"179","author":"Zhao","year":"2019","journal-title":"JAMA Intern Med"},{"key":"B10","first-page":"841","article-title":"Its application and research in the treatment of coronary heart disease from the effect of kidney tonification on blood veins","volume":"33","author":"Liu","year":"2018","journal-title":"Chin J Trad Chin Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.3969\/j.issn.1672-1349.2017.14.041","article-title":"Application and research of kidney tonification and blood revitalization method in cardiovascular disease","volume":"15","author":"He","year":"2017","journal-title":"J Cardiovasc Cerebrovasc Dis Integr Trad West Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.16281\/j.cnki.jocml.2015.09.083","article-title":"Research progress on the pharmacological effects and clinical application of chuanxiongzine in cardiovascular and cerebrovascular diseases","volume":"2","author":"Wu","year":"2015","journal-title":"Electron J Clin Med Lit"},{"key":"B13","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3969\/j.issn.1673-7555.2009.07.100","article-title":"Pharmacological effects and clinical application progress of chuanxiongzine on cardiovascular protection","volume":"4","author":"Zhang","year":"2009","journal-title":"China Pract Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3969\/j.issn.2095-6681.2018.35.125","article-title":"Effect of Danshen Wuchuanxiong on blood rheology in patients with coronary heart disease","volume":"6","author":"Cheng","year":"2018","journal-title":"Electron J Integr Trad West Med Cardiovasc Dis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"97","DOI":"10.12206\/j.issn.1006-0111.202006087","article-title":"Research progress on pharmacological effects of red peony","volume":"39","author":"Zhang","year":"2021","journal-title":"J Pharm Pract"},{"key":"B16","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3321\/j.issn:0253-2670.1999.02.019","article-title":"Protective effect of cistanche total glycoside on myocardial ischemia in rats","volume":"2","author":"Mao","year":"1999","journal-title":"Chin Trad Herb Drugs"},{"key":"B17","first-page":"277","article-title":"Effect of halberdium on myocardial ischemia-reperfusion injury in rats","volume":"33","author":"Li","year":"2012","journal-title":"J Mil Med Coll"},{"key":"B18","doi-asserted-by":"publisher","first-page":"18","DOI":"10.16282\/j.cnki.cn11-9336\/r.2019.23.011","article-title":"Pharmacological effects and research progress of guarana in the treatment of coronary heart disease","volume":"7","author":"Huang","year":"2019","journal-title":"Electron J Cardiovasc Dis Integr Trad West Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"152","DOI":"10.13638\/j.issn.1671-4040.2017.01.090","article-title":"Study on the anti-inflammatory effect of Guizhi decoction on the activation of microglia","volume":"17","author":"Hu","year":"2017","journal-title":"Clin Pract Integr Trad Chin West Med"},{"key":"B20","first-page":"51","article-title":"Clinical effect and pharmacological effect analysis of Panax notoginseng saponins in the treatment of hyperlipidemia","volume":"6","author":"Chen","year":"2016","journal-title":"Chin Med Sci"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1034870","DOI":"10.3389\/fphar.2022.1034870","article-title":"Functional compounds of ginseng and ginseng-containing medicine for treating cardiovascular diseases","volume":"13","author":"Liu","year":"2022","journal-title":"Front Pharmacol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"206","DOI":"10.13375\/j.cnki.wcjps.2022.02.021","article-title":"Research progress on chemical composition and pharmacological effects of goji berry and prediction analysis of quality markers","volume":"37","author":"Song","year":"2022","journal-title":"West China J Pharm"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1293818\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T10:12:19Z","timestamp":1721383939000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1293818\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,4]]},"references-count":22,"alternative-id":["10.3389\/fcvm.2024.1293818"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2024.1293818","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,4]]},"article-number":"1293818"}}