{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:05:46Z","timestamp":1776942346526,"version":"3.51.4"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Preeclampsia (PE) is associated with subsequent higher risk of cardiovascular and kidney disease. Serum copeptin, as a proxy for vasopressin, and urinary uromodulin, were associated with PE physiopathology and kidney functional mass respectively. We describe concentrations of these proteins in the post-partum period and characterize their association with persistent hypertension (HTN) or albuminuria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with PE and healthy controls with uncomplicated pregnancy were prospectively included at two teaching hospitals in Switzerland. Clinical parameters along with serum copeptin and urinary uromodulin were measured at 6 weeks post-partum. PE patients were further characterized based on presence of HTN (defined as either systolic BP (SBP) \u2265140\u2005mmHg or diastolic (BP) \u226590\u2005mmHg) or albuminuria [defined as urinary albumin to creatinine ratio (ACR) \u22653\u2005mg\/mmol].<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 226 patients with 35 controls, 120 (62.8%) PE with persistent HTN\/albuminuria and 71 (37.1%) PE without persistent HTN\/albuminuria. Median serum copeptin concentration was 4.27 (2.9\u20136.2)\u2005pmol\/L without differences between study groups (<jats:italic>p<\/jats:italic>\u2009&amp;gt;\u20090.05). Higher copeptin levels were associated with higher SBP in controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.039), but not in PE (<jats:italic>p<\/jats:italic>\u2009&amp;gt;\u20090.05). Median urinary uromodulin concentration was 17.5 (7.8\u201328.7)\u2005mg\/g with lower levels in PE patients as compared to healthy controls (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001), but comparable levels between PE patients with or without HTN\/albuminuria (<jats:italic>p<\/jats:italic>\u2009&amp;gt;\u20090.05). Higher uromodulin levels were associated with lower albuminuria in PE as well as control patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.040).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum copeptin levels at 6 weeks post-partum are similar between PE patients and healthy controls and cannot distinguish between PE with or without residual kidney damage. This would argue against a significant pathophysiological role of the vasopressin pathway in mediating organ damage in the post-partum period. On the opposite, post-partum urinary uromodulin levels are markedly lower in PE patients as compared to healthy controls, potentially reflecting an increased susceptibility to vascular and kidney damage that could associate with adverse long-term cardiovascular and kidney outcomes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2024.1310300","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T04:54:23Z","timestamp":1709528063000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of serum copeptin and urinary uromodulin with kidney function, blood pressure and albuminuria at 6 weeks post-partum in pre-eclampsia"],"prefix":"10.3389","volume":"11","author":[{"given":"David A.","family":"Jaques","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Dufey Teso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gr\u00e9goire","family":"Wuerzner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Begona","family":"Martinez De Tejada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marika","family":"Santagata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Othenin Girard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9n\u00e9dicte","family":"Le Tinier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoinette","family":"Pechere Bertschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belen","family":"Ponte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.preghy.2014.02.001","article-title":"The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP","volume":"4","author":"Tranquilli","year":"2014","journal-title":"Pregnancy Hypertens"},{"key":"B2","doi-asserted-by":"publisher","first-page":"F614","DOI":"10.1152\/ajprenal.00470.2007","article-title":"Course of preeclamptic glomerular injury after delivery","volume":"294","author":"Hladunewich","year":"2008","journal-title":"Am J Physiol\u2014Ren Physiol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e323","DOI":"10.1016\/S2214-109X(14)70227-X","article-title":"Global causes of maternal death: a WHO systematic analysis","volume":"2","author":"Say","year":"2014","journal-title":"Lancet Glob Heal"},{"key":"B4","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.ahj.2008.06.042","article-title":"Cardiovascular sequelae of preeclampsia\/eclampsia: a systematic review and meta-analyses","volume":"156","author":"McDonald","year":"2008","journal-title":"Am Heart J"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1093\/ndt\/14.5.1129","article-title":"Microalbuminuria after pregnancy complicated by pre-eclampsia","volume":"14","author":"Bar","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1161\/CIRCULATIONAHA.109.909663","article-title":"Plasma copeptin and the risk of diabetes mellitus","volume":"121","author":"Enh\u00f6rning","year":"2010","journal-title":"Circulation"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1161\/HYPERTENSIONAHA.114.03762","article-title":"Increased levels of copeptin before clinical diagnosis of preelcampsia","volume":"64","author":"Yeung","year":"2014","journal-title":"Hypertension"},{"key":"B8","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1161\/HYPERTENSIONAHA.114.03848","article-title":"Vasopressin in preeclampsia: a novel very early human pregnancy biomarker and clinically relevant mouse model","volume":"64","author":"Santillan","year":"2014","journal-title":"Hypertension"},{"key":"B9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/ki.2009.397","article-title":"Copeptin, a surrogate marker of vasopressin, is associated with microalbuminuria in a large population cohort","volume":"77","author":"Meijer","year":"2010","journal-title":"Kidney Int"},{"key":"B10","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1159\/000439061","article-title":"Plasma copeptin and decline in renal function in a cohort from the community: the prospective D.E.S.I.R. 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