{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:14:25Z","timestamp":1785248065084,"version":"3.55.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Extracorporeal membrane oxygenation (ECMO) is an advanced life support that has been utilized in the neonate for refractory respiratory and circulatory failure. Striving for the best outcomes and understanding optimal surgical techniques continue to be at the forefront of discussion and research. This study presents a single-center experience of cervically cannulated neonatal patients on V-A ECMO, a description of our cannulation\/decannulation techniques and our patient outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Single center retrospective review of neonates who received neck V-A ECMO support from January 2012 to December 2022. The data and outcomes of the patients were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 78 neonates received V-A ECMO support. There were 66 patients that received ECMO for respiratory support, the other 12 patients that received ECMO for cardiac support. The median duration of ECMO support was 109 (32\u2013293) hours for all patients. During ECMO support, 20 patients died and 5 patients discontinued treatment due to poor outcome or the cost. A total of 53 (68%) patients were successfully weaned from ECMO, but 3 of them died in the subsequent treatment. Overall 50 (64%) patients survived to hospital discharge. In this study, 48 patients were cannulated using the vessel sparing technique, the other 30 patients were cannulated using the ligation technique. We found no significant difference in the rates of normal cranial MRI at discharge between survivors with and without common carotid artery ligation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We achieved satisfactory outcomes of neonatal ECMO in 11-year experience. This study found no significant difference in early neuroimaging between survivors with and without common carotid artery ligation. The long-term neurological function of ECMO survivors warranted further follow-up and study.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2024.1322231","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T05:31:30Z","timestamp":1707283890000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Veno-arterial extracorporeal membrane oxygenation for respiratory and cardiac support in neonates: a single center experience"],"prefix":"10.3389","volume":"11","author":[{"given":"Gang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengxu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1097\/MAT.0000000000000697","article-title":"Esperanza: the first neonatal ECMO patient","volume":"63","author":"Bartlett","year":"2017","journal-title":"ASAIO J"},{"key":"B2","year":"2023"},{"key":"B3","doi-asserted-by":"publisher","first-page":"101404","DOI":"10.1016\/j.siny.2022.101404","article-title":"Cannulation and decannulation techniques for neonatal ECMO","volume":"27","author":"Jensen","year":"2022","journal-title":"Semin Fetal Neonatal Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jpedsurg.2014.10.029","article-title":"Neonatal carotid repair at ECMO decannulation: patency rates and early neurologic outcomes","volume":"50","author":"Duggan","year":"2015","journal-title":"J Pediatr Surg"},{"key":"B5","volume-title":"Neonatal Respiratory Failure Supplement to the ELSO General Guidelines. Version 1.4","year":"2017"},{"key":"B6","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1053\/j.semperi.2017.12.003","article-title":"Current trends in neonatal ECMO","volume":"42","author":"Mahmood","year":"2018","journal-title":"Semin Perinatol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1136\/adc.2008.141051","article-title":"Neonatal extracorporeal membrane oxygenation: practice patterns and predictors of outcome in the UK","volume":"94","author":"Karimova","year":"2009","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fped.2018.00263","article-title":"Neonatal extracorporeal membrane oxygenation due to respiratory failure: a single center experience over 28 years","volume":"6","author":"Reiterer","year":"2018","journal-title":"Front Pediatr"},{"key":"B9","doi-asserted-by":"publisher","first-page":"355","DOI":"10.47102\/annals-acadmedsg.V43N7p355","article-title":"Neonatal and paediatric extracorporeal membrane oxygenation (ECMO) in a single Asian tertiary centre","volume":"43","author":"Yeo","year":"2014","journal-title":"Ann Acad Med Singap"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1097\/PCC.0000000000000943","article-title":"Association of extracorporeal membrane oxygenation support adequacy and residual lesions with outcomes in neonates supported after cardiac surgery","volume":"17","author":"Howard","year":"2016","journal-title":"Pediatr Crit Care Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.2214\/AJR.06.1319","article-title":"Extracorporeal membrane oxygenation in infants with congenital diaphragmatic hernia: follow-up MRI evaluating carotid artery reocclusion and neurologic outcome","volume":"188","author":"Buesing","year":"2007","journal-title":"AJR Am J Roentgenol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1016\/j.jpedsurg.2017.08.001","article-title":"Patency of common carotid artery and internal jugular vein after a simple vessel sparing cannulation for extracorporeal membrane oxygenation support","volume":"52","author":"Kurkluoglu","year":"2017","journal-title":"J Pediatr Surg"},{"key":"B13","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/S0022-3476(88)80543-2","article-title":"Right common carotid artery ligation in extracorporeal membrane oxygenation","volume":"113","author":"Campbell","year":"1988","journal-title":"J Pediatr"},{"key":"B14","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1542\/peds.82.2.155","article-title":"Right-sided brain lesions in infants following extracorporeal membrane oxygenation","volume":"82","author":"Schumacher","year":"1988","journal-title":"Pediatrics"},{"key":"B15","first-page":"277","article-title":"Extracorporeal membrane oxygenation","volume-title":"Assisted Ventilation of the Neonate","author":"Arensman","year":"2010"},{"key":"B16","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1001\/archpedi.1990.02150320036021","article-title":"Carotid artery reconstruction following extracorporeal membrane oxygenation","volume":"144","author":"Crombleholme","year":"1990","journal-title":"Am J Dis Child"},{"key":"B17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1053\/j.semperi.2007.12.010","article-title":"Neuroimaging and neurodevelopmental outcomes in preterm infants","volume":"32","author":"Hintz","year":"2008","journal-title":"Semin Perinatol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.earlhumdev.2009.08.060","article-title":"The ELGAN study of the brain and related disorders in extremely low gestational age newborns","volume":"85","author":"O\u2019Shea","year":"2009","journal-title":"Early Hum Dev"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1542\/peds.2009-0953","article-title":"Neurodevelopmental outcome of infants with unilateral or bilateral periventricular hemorrhagic infarction","volume":"124","author":"Maitre","year":"2009","journal-title":"Pediatrics"},{"key":"B20","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/0887-8994(95)00047-J","article-title":"MRI, MRA, and neurodevelopmental outcome following neonatal ECMO","volume":"12","author":"Lago","year":"1995","journal-title":"Pediatr Neurol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/S0022-3468(85)80230-X","article-title":"Long-term follow-up of infants and children treated with extracorporeal membrane oxygenation (ECMO): a preliminary report","volume":"20","author":"Towne","year":"1985","journal-title":"J Pediatr Surg"},{"key":"B22","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/S0022-3476(99)70199-X","article-title":"Five-year follow-up of neonates with reconstructed right common carotid arteries after extracorporeal membrane oxygenation","volume":"134","author":"Desai","year":"1999","journal-title":"J Pediatr"},{"key":"B23","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1515\/jpm-2019-0234","article-title":"The utility of cranial ultrasound as a screening tool for neonatal ECMO","volume":"48","author":"McCutcheon","year":"2020","journal-title":"J Perinat Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1148\/radiology.175.1.2315469","article-title":"Right carotid artery ligation in neonates: classification of collateral flow with color Doppler imaging","volume":"175","author":"Mitchell","year":"1990","journal-title":"Radiology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1161\/01.STR.0000198880.28827.84","article-title":"Magnetic resonance angiography of cerebral arteries after neonatal venoarterial and venovenous extracorporeal membrane oxygenation","volume":"37","author":"Hendrikse","year":"2006","journal-title":"Stroke"},{"key":"B26","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/0022-3468(90)90193-D","article-title":"Carotid artery repair after pediatric extracorporeal membrane oxygenation","volume":"25","author":"Adolph","year":"1990","journal-title":"J Pediatr Surg"},{"key":"B27","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s003830050004","article-title":"Effects of carotid artery repair following neonatal extracorporeal membrane oxygenation","volume":"16","author":"Sarioglu","year":"2000","journal-title":"Pediatr Surg Int"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1322231\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T05:31:33Z","timestamp":1707283893000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1322231\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,7]]},"references-count":27,"alternative-id":["10.3389\/fcvm.2024.1322231"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2024.1322231","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,7]]},"article-number":"1322231"}}