{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T04:55:28Z","timestamp":1767156928267,"version":"3.41.2"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:00:00Z","timestamp":1715040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Viral myocarditis is an important cause of non-ischemic cardiomyopathy. Multiple clinical manifestations have been reported, including acute heart failure, cardiogenic shock, and ventricular arrhythmias. We present three patients with clinically suspected viral myocarditis causing acute heart failure. Serum coxsackievirus B antibodies were positive in all three patients. Each case resulted in significant clinical improvement with hemodynamic support and acute recovery of left ventricular ejection fraction. Despite an initial critical presentation concerning for cardiogenic shock, we highlight three cases of clinically suspected coxsackie myocarditis with an excellent short-term prognosis.<\/jats:p>","DOI":"10.3389\/fcvm.2024.1345449","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T04:39:02Z","timestamp":1715056742000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Three cases of clinically suspected viral myocarditis with recovery of left ventricular dysfunction"],"prefix":"10.3389","volume":"11","author":[{"given":"Jonathan","family":"Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hytham","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siva T.","family":"Sarva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhas","family":"Tatapudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeby","family":"Kalathoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aswin","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed","family":"Raza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/nrcardio.2015.108","article-title":"Viral myocarditis\u2013diagnosis, treatment options, and current controversies","volume":"12","author":"Pollack","year":"2015","journal-title":"Nat Rev Cardiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/S0140-6736(11)60648-X","article-title":"Myocarditis","volume":"379","author":"Sagar","year":"2012","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1093\/eurheartj\/eht210","article-title":"Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology working group on myocardial and pericardial diseases","volume":"34","author":"Caforio","year":"2013","journal-title":"Eur Heart J"},{"key":"B4","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1161\/01.CIR.95.1.163","article-title":"Elevations of cardiac troponin I associated with myocarditis. Experimental and clinical correlates","volume":"95","author":"Smith","year":"1997","journal-title":"Circulation"},{"key":"B5","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/0735-1097(92)90141-9","article-title":"Viral myocarditis mimicking acute myocardial infarction","volume":"20","author":"Dec","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1016\/j.jacc.2007.09.008","article-title":"The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American heart association, the American college of cardiology, and the European Society of Cardiology. Endorsed by the heart failure society of America and the heart failure association of the European Society of Cardiology","volume":"50","author":"Cooper","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"279","DOI":"10.14744\/AnatolJCardiol.2017.8170","article-title":"Fulminant myocarditis: characteristics, treatment, and outcomes","volume":"19","author":"Veronese","year":"2018","journal-title":"Anatol J Cardiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"6272","DOI":"10.1073\/pnas.84.17.6272","article-title":"In situ detection of enteroviral genomes in myocardial cells by nucleic acid hybridization: an approach to the diagnosis of viral heart disease","volume":"84","author":"Kandolf","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1161\/CIRCULATIONAHA.105.548156","article-title":"Viral persistence in the myocardium is associated with progressive cardiac dysfunction","volume":"112","author":"K\u00fchl","year":"2005","journal-title":"Circulation"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e007405","DOI":"10.1161\/CIRCHEARTFAILURE.120.007405","article-title":"Management of acute myocarditis and chronic inflammatory cardiomyopathy: an expert consensus document","volume":"13","author":"Ammirati","year":"2020","journal-title":"Circ Heart Fail"},{"key":"B11","doi-asserted-by":"publisher","first-page":"H69","DOI":"10.1152\/ajpheart.00154.2007","article-title":"Antiviral and myocyte protective effects of murine interferon-beta and -{alpha}2 in coxsackievirus B3-induced myocarditis and epicarditis in balb\/c mice","volume":"293","author":"Wang","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1007\/s00392-016-0986-9","article-title":"Betaferon in chronic viral cardiomyopathy (BICC) trial: effects of interferon-\u03b2 treatment in patients with chronic viral cardiomyopathy","volume":"105","author":"Schultheiss","year":"2016","journal-title":"Clin Res Cardiol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e005250","DOI":"10.1161\/CIRCHEARTFAILURE.119.005250","article-title":"Early treatment of coxsackievirus B3-infected animals with soluble coxsackievirus-adenovirus receptor inhibits development of chronic coxsackievirus B3 cardiomyopathy","volume":"12","author":"Pinkert","year":"2019","journal-title":"Circ Heart Fail"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1345449\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T04:39:06Z","timestamp":1715056746000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1345449\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,7]]},"references-count":13,"alternative-id":["10.3389\/fcvm.2024.1345449"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2024.1345449","relation":{},"ISSN":["2297-055X"],"issn-type":[{"type":"electronic","value":"2297-055X"}],"subject":[],"published":{"date-parts":[[2024,5,7]]},"article-number":"1345449"}}