{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:15:45Z","timestamp":1791803745488,"version":"4.3.4"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Transthyretin amyloidosis (ATTR) is a condition defined by accumulation of insoluble transthyretin amyloid deposits in multiple organs, especially in the peripheral nerve and heart muscle. ATTR may result from transthyretin mutations (variant ATTR or ATTRv) or may occur with normal transthyretin genotype (wild type ATTR or ATTRwt). ATTRwt was previously known as \u201csenile amyloidosis\u201d and causes cardiomyopathy which may lead to heart failure with a preserved ejection fraction, affecting predominantly elderly men. The exact prevalence of ATTRwt in the general population remains unclear, but its occurrence may be underestimated in women. It was observed that a proportion of ATTRwt cardiomyopathy patients may develop slowly progressing neuropathy that is milder and indolent in comparison with typical progressive neuropathy associated with ATTRv. Furthermore, the causality of neuropathy is often uncertain in patients with ATTRwt. Neuropathy symptoms, including distal sensory loss, unsteadiness and (neuropathic) pain are common in elderly patients with multiple potential causes, and as ATTRwt patients are typically older, relatively high prevalence of peripheral neuropathy is expected with frequent comorbidities. Relatively high prevalence of ATTRwt in elderly population contrasts few documented cases of neuropathy caused by ATTRwt, and there is uncertainty whether ATTRwt neuropathy is an infrequent occurrence or a significant manifestation of multisystemic ATTRwt. We review neurologic and musculoskeletal manifestations of ATTRwt and present clinical features of a single center cohort of ATTRwt patients with suspected peripheral neuropathy.<\/jats:p>","DOI":"10.3389\/fcvm.2024.1345608","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T04:45:48Z","timestamp":1707713148000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Neuromuscular manifestations of wild type transthyretin amyloidosis: a review and single center\u2019s experience"],"prefix":"10.3389","volume":"11","author":[{"given":"Sasha A.","family":"\u017divkovi\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lacomis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem","family":"Soman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s40120-020-00217-0","article-title":"A narrative review of the role of transthyretin in health and disease","volume":"9","author":"Liz","year":"2020","journal-title":"Neurol Ther"},{"key":"B2","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1002\/mus.20821","article-title":"The molecular biology and clinical features of amyloid neuropathy","volume":"36","author":"Benson","year":"2007","journal-title":"Muscle Nerve"},{"key":"B3","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1186\/s13023-023-02962-5","article-title":"A 15-year consolidated overview of data in over 6000 patients from the transthyretin amyloidosis outcomes survey (THAOS)","volume":"18","author":"Gentile","year":"2023","journal-title":"Orphanet J Rare Dis"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.jacc.2016.06.033","article-title":"Natural history of wild-type transthyretin cardiac amyloidosis and risk stratification using a novel staging system","volume":"68","author":"Grogan","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1002\/ehf2.12884","article-title":"Clinical characteristics and natural history of wild-type transthyretin amyloid cardiomyopathy in Japan","volume":"7","author":"Yamada","year":"2020","journal-title":"ESC Heart Fail"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1016\/j.jacc.2018.07.092","article-title":"Tenosynovial and cardiac amyloidosis in patients undergoing carpal tunnel release","volume":"72","author":"Sperry","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12891-020-03912-z","article-title":"Musculoskeletal pathology as an early warning sign of systemic amyloidosis: a systematic review of amyloid deposition and orthopedic surgery","volume":"22","author":"Wininger","year":"2021","journal-title":"BMC Musculoskelet Disord"},{"key":"B8","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1001\/jama.2017.9236","article-title":"Association between ruptured distal biceps tendon and wild-type transthyretin cardiac amyloidosis","volume":"318","author":"Geller","year":"2017","journal-title":"JAMA"},{"key":"B9","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/modpathol.2014.102","article-title":"Amyloid deposits derived from transthyretin in the ligamentum flavum as related to lumbar spinal canal stenosis","volume":"28","author":"Yanagisawa","year":"2015","journal-title":"Mod Pathol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1002\/mus.21400","article-title":"Patient with amyloidoma of the ulnar nerve and salivary glands","volume":"40","author":"Salameh","year":"2009","journal-title":"Muscle Nerve"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1016\/j.humpath.2011.03.004","article-title":"High prevalence of wild-type transthyretin deposition in patients with idiopathic carpal tunnel syndrome: a common cause of carpal tunnel syndrome in the elderly","volume":"42","author":"Sekijima","year":"2011","journal-title":"Hum Pathol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1007\/s11999-015-4450-3","article-title":"Prevalence and risk factors of spine, shoulder, hand, hip, and knee osteoarthritis in community-dwelling Koreans older than age 65 years","volume":"473","author":"Cho","year":"2015","journal-title":"Clin Orthop Relat Res"},{"key":"B13","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3109\/13506129.2015.1115758","article-title":"Knee osteoarthritis associated with different kinds of amyloid deposits and the impact of aging on type of amyloid","volume":"23","author":"Yanagisawa","year":"2016","journal-title":"Amyloid"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1016\/j.humpath.2010.11.017","article-title":"Wild-type transthyretin-derived amyloidosis in various ligaments and tendons","volume":"42","author":"Sueyoshi","year":"2011","journal-title":"Hum Pathol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1002\/mus.26723","article-title":"Transthyretin amyloidosis: putting myopathy on the map","volume":"61","author":"Pinto","year":"2020","journal-title":"Muscle Nerve"},{"key":"B16","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1080\/07853890701842988","article-title":"Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study","volume":"40","author":"Tanskanen","year":"2008","journal-title":"Ann Med"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1212\/WNL.0000000000003293","article-title":"Prevalence of polyneuropathy in the general middle-aged and elderly population","volume":"87","author":"Hanewinckel","year":"2016","journal-title":"Neurology"},{"key":"B18","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/jns.12403","article-title":"Peripheral neuropathy symptoms in wild type transthyretin amyloidosis","volume":"25","author":"Yungher","year":"2020","journal-title":"J Peripher Nerv Syst"},{"key":"B19","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1080\/13506129.2019.1697224","article-title":"Late-onset peripheral neuropathy in patients with wild type transthyretin amyloidosis (wtATTR)","volume":"27","author":"Zivkovic","year":"2020","journal-title":"Amyloid"},{"key":"B20","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1212\/WNL.0000000000001870","article-title":"Rapid progression of familial amyloidotic polyneuropathy: a multinational natural history study","volume":"85","author":"Adams","year":"2015","journal-title":"Neurology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1017\/cjn.2020.271","article-title":"Utility of neuropathy screening for wild-type transthyretin amyloidosis patients","volume":"48","author":"Russell","year":"2021","journal-title":"Can J Neurol Sci"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/S10072-022-06459-0","article-title":"Peripheral nerve involvement in wild-type transthyretin amyloidosis","author":"Campagnolo","year":"2022","journal-title":"Neurol Sci"},{"key":"B23","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1080\/13506129.2021.2014448","article-title":"Same same, but different? The neurological presentation of wildtype transthyretin (ATTRwt) amyloidosis","volume":"29","author":"Kleefeld","year":"2022","journal-title":"Amyloid"},{"key":"B24","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1080\/13506129.2021.1976751","article-title":"Clinical and apparative investigation of large and small nerve fiber impairment in mixed cohort of ATTR-amyloidosis: impact on patient management and new insights in wild-type","volume":"29","author":"Papagianni","year":"2022","journal-title":"Amyloid"},{"key":"B25","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/jns.12153","article-title":"\u201cRed-flag\u201d symptom clusters in transthyretin familial amyloid polyneuropathy","volume":"21","author":"Conceicao","year":"2016","journal-title":"J Peripher Nerv Syst"},{"key":"B26","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1080\/13506129.2021.1950681","article-title":"Association between spinal stenosis and wild-type ATTR amyloidosis","volume":"28","author":"Godara","year":"2021","journal-title":"Amyloid"},{"key":"B27","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1002\/ejhf.1742","article-title":"Carpal tunnel syndrome in cardiac amyloidosis: implications for early diagnosis and prognostic role across the spectrum of aetiologies","volume":"22","author":"Milandri","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1007\/s00392-019-01467-1","article-title":"Carpal tunnel syndrome and spinal canal stenosis: harbingers of transthyretin amyloid cardiomyopathy?","volume":"108","author":"Aus dem Siepen","year":"2019","journal-title":"Clin Res Cardiol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1002\/art.39178","article-title":"Transthyretin deposition in articular cartilage: a novel mechanism in the pathogenesis of osteoarthritis","volume":"67","author":"Akasaki","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e325","DOI":"10.1016\/j.wneu.2020.06.228","article-title":"Wild-type transthyretin amyloidosis occurring in the ligamentum flavum of the cervicothoracic spine","volume":"142","author":"George","year":"2020","journal-title":"World Neurosurg"},{"key":"B31","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.cell.2005.01.018","article-title":"The biological and chemical basis for tissue-selective amyloid disease","volume":"121","author":"Sekijima","year":"2005","journal-title":"Cell"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1212\/WNL.0000000000003362","article-title":"Schwann cell and endothelial cell damage in transthyretin familial amyloid polyneuropathy","volume":"87","author":"Koike","year":"2016","journal-title":"Neurology"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26154611","article-title":"The ultrastructure of tissue damage by amyloid fibrils","volume":"26","author":"Koike","year":"2021","journal-title":"Molecules"},{"key":"B34","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.ajo.2018.05.023","article-title":"Angiographic signatures of the predominant form of familial transthyretin amyloidosis (Val30Met mutation)","volume":"192","author":"Rousseau","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1161\/CIRCULATIONAHA.108.843334","article-title":"Systemic cardiac amyloidoses: disease profiles and clinical courses of the 3 main types","volume":"120","author":"Rapezzi","year":"2009","journal-title":"Circulation"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1110\/ps.8901","article-title":"Transthyretin slowly exchanges subunits under physiological conditions: a convenient chromatographic method to study subunit exchange in oligomeric proteins","volume":"10","author":"Schneider","year":"2001","journal-title":"Protein Sci"},{"key":"B37","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.jns.2009.07.028","article-title":"Distinct characteristics of amyloid deposits in early- and late-onset transthyretin Val30Met familial amyloid polyneuropathy","volume":"287","author":"Koike","year":"2009","journal-title":"J Neurol Sci"},{"key":"B38","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1002\/mus.10452","article-title":"Contribution of wild-type transthyretin to hereditary peripheral nerve amyloid","volume":"28","author":"Yazaki","year":"2003","journal-title":"Muscle Nerve"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.amjmed.2017.12.042","article-title":"Approach to peripheral neuropathy for the primary care clinician","volume":"131","author":"Doughty","year":"2018","journal-title":"Am J Med"},{"key":"B40","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3949\/ccjm.72.1.37","article-title":"Electrodiagnostic testing of nerves and muscles: when, why, and how to order","volume":"72","author":"Chemali","year":"2005","journal-title":"Cleve Clin J Med"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1136\/jnnp-2014-308724","article-title":"Transthyretin (ATTR) amyloidosis: clinical spectrum, molecular pathogenesis and disease-modifying treatments","volume":"86","author":"Sekijima","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"B42","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.pneurobio.2003.11.002","article-title":"Neurodegeneration in familial amyloid polyneuropathy: from pathology to molecular signaling","volume":"71","author":"Sousa","year":"2003","journal-title":"Prog Neurobiol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1161\/CIRCULATIONAHA.115.018852","article-title":"Heart failure resulting from age-related cardiac amyloid disease associated with wild-type transthyretin: a prospective, observational cohort study","volume":"133","author":"Connors","year":"2016","journal-title":"Circulation"},{"key":"B44","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1212\/WNL.0b013e3181ea15d4","article-title":"Progression of transthyretin amyloid neuropathy after liver transplantation","volume":"75","author":"Liepnieks","year":"2010","journal-title":"Neurology"},{"key":"B45","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1002\/mus.10181","article-title":"Small-fiber neuropathy","volume":"26","author":"Lacomis","year":"2002","journal-title":"Muscle Nerve"},{"key":"B46","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1111\/j.1468-1331.2010.03023.x","article-title":"European federation of neurological societies\/peripheral nerve society guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European federation of neurological societies and the peripheral nerve society","volume":"17","author":"Lauria","year":"2010","journal-title":"Eur J Neurol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s10286-018-0514-2","article-title":"Autonomic involvement in hereditary transthyretin amyloidosis (hATTR amyloidosis)","volume":"29","author":"Gonzalez-Duarte","year":"2019","journal-title":"Clin Auton Res"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.4065\/83.11.1226","article-title":"Patterns of neuropathy and autonomic failure in patients with amyloidosis","volume":"83","author":"Wang","year":"2008","journal-title":"Mayo Clin Proc"},{"key":"B49","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S1474-4422(22)00432-X","article-title":"Carpal tunnel syndrome: updated evidence and new questions","volume":"22","author":"Padua","year":"2023","journal-title":"Lancet Neurol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.jacc.2022.06.026","article-title":"Screening for cardiac amyloidosis 5 to 15 years after surgery for bilateral carpal tunnel syndrome","volume":"80","author":"Westin","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/S0266-7681(98)80010-7","article-title":"Incidence of bilateral symptoms in carpal tunnel syndrome","volume":"23","author":"Padua","year":"1998","journal-title":"J Hand Surg Br"},{"key":"B52","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1002\/mus.25742","article-title":"Carpal tunnel syndrome in inherited neuropathies: a retrospective survey","volume":"57","author":"Panosyan","year":"2018","journal-title":"Muscle Nerve"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11061674","article-title":"Carpal tunnel syndrome and diabetes-A comprehensive review","volume":"11","author":"Zimmerman","year":"2022","journal-title":"J Clin Med"},{"key":"B54","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1177\/0363546515587738","article-title":"Distal biceps tendon ruptures: an epidemiological analysis using a large population database","volume":"43","author":"Kelly","year":"2015","journal-title":"Am J Sports Med"},{"key":"B55","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.jhsg.2022.08.008","article-title":"Prevalence of amyloid deposition in patients undergoing surgical repair of traumatic distal biceps tendon ruptures","volume":"4","author":"Baylor","year":"2022","journal-title":"J Hand Surg Glob Online"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-022-02990-x","article-title":"Amyloid myopathy: expanding the clinical spectrum of transthyretin amyloidosis-case report and literature review","author":"Ungericht","year":"2022","journal-title":"J Nucl Cardiol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/mus.27740","article-title":"(99m) technetium-pyrophosphate bone scan: a potential biomarker for the burden of transthyretin amyloidosis in skeletal muscle: a preliminary study","volume":"67","author":"Wlodarski","year":"2023","journal-title":"Muscle Nerve"},{"key":"B58","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1097\/CND.0000000000000288","article-title":"Wild-type transthyretin amyloid myopathy with an inclusion body myositis phenotype","volume":"22","author":"Huser","year":"2020","journal-title":"J Clin Neuromuscul Dis"},{"key":"B59","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/CND.0000000000000356","article-title":"Variable presentation of hereditary transthyretin-mediated amyloidosis at a single center","volume":"23","author":"Hussain","year":"2021","journal-title":"J Clin Neuromuscul Dis"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1212\/WNL.0000000000012965","article-title":"CNS involvement in hereditary transthyretin amyloidosis","volume":"97","author":"Sousa","year":"2021","journal-title":"Neurology"},{"key":"B61","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1212\/WNL.0000000000003001","article-title":"Cerebral amyloid angiopathy in posttransplant patients with hereditary ATTR amyloidosis","volume":"87","author":"Sekijima","year":"2016","journal-title":"Neurology"},{"key":"B62","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3109\/13506129909007312","article-title":"Analysis of transthyretin amyloid fibrils from vitreous samples in familial amyloidotic polyneuropathy (Val30Met)","volume":"6","author":"Ando","year":"1999","journal-title":"Amyloid"},{"key":"B63","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1080\/13506129.2018.1436048","article-title":"Monoclonal gammopathy of undetermined significance in systemic transthyretin amyloidosis (ATTR)","volume":"25","author":"Phull","year":"2018","journal-title":"Amyloid"},{"key":"B64","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41408-019-0193-9","article-title":"Two types of amyloidosis presenting in a single patient: a case series","volume":"9","author":"Sidiqi","year":"2019","journal-title":"Blood Cancer J"},{"key":"B65","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/mus.23521","article-title":"Liver transplantation and transthyretin amyloidosis","volume":"47","author":"Benson","year":"2013","journal-title":"Muscle Nerve"},{"key":"B66","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1080\/13506120701614032","article-title":"Progression of cardiac amyloid deposition in hereditary transthyretin amyloidosis patients after liver transplantation","volume":"14","author":"Liepnieks","year":"2007","journal-title":"Amyloid"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1075806","DOI":"10.3389\/fcvm.2022.1075806","article-title":"Cardiac transplantation in transthyretin amyloid cardiomyopathy: outcomes from three decades of tertiary center experience","volume":"9","author":"Razvi","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B68","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.healun.2021.10.007","article-title":"Surveillance for disease progression of transthyretin amyloidosis after heart transplantation in the era of novel disease modifying therapies","volume":"41","author":"Griffin","year":"2022","journal-title":"J Heart Lung Transplant"},{"key":"B69","doi-asserted-by":"publisher","first-page":"101925","DOI":"10.1016\/j.arr.2023.101925","article-title":"Frail older adults are more likely to have autonomic dysfunction: a systematic review and meta-analysis","volume":"87","author":"Debain","year":"2023","journal-title":"Ageing Res Rev"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1093\/ageing\/afab090","article-title":"Prevalence of initial orthostatic hypotension in older adults: a systematic review and meta-analysis","volume":"50","author":"Tran","year":"2021","journal-title":"Age Ageing"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1345608\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T04:45:50Z","timestamp":1707713150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1345608\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,12]]},"references-count":70,"alternative-id":["10.3389\/fcvm.2024.1345608"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2024.1345608","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,12]]},"article-number":"1345608"}}