{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:12:00Z","timestamp":1787026320149,"version":"build-2736575974"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Phlegmasia cerulea dolens (PCD) is a rare yet severe complication of deep vein thrombosis (DVT), characterized by a high amputation rate and mortality. Early diagnosis and treatment are crucial in managing this condition. PCD predominantly affects the lower extremities rather than the upper extremities. We herein present a rare upper extremity PCD case accompanied with supra vena cava and pulmonary embolism in a cervical cancer patient, who presented to our institution with severe pain, edema and irreversible venous gangrene of right upper limb with no response to anticoagulation therapy. Emergency fasciotomy and amputation were performed due to the progressed venous gangrene, however, the patient developed severe infection and coagulation disorders, gastrointestinal bleeding and disseminated intravascular coagulation after the surgery. Despite medical interventions, her family chose to withdraw treatment and the patient died in ICU at the fourth day following emergency surgery.<\/jats:p>","DOI":"10.3389\/fcvm.2024.1351358","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T23:30:55Z","timestamp":1707175855000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Upper extremity phlegmasia cerulea dolens complicating supra vena cava embolism in a cervical cancer patient: case report"],"prefix":"10.3389","volume":"11","author":[{"given":"Jinting","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxin","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiehao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.avsg.2021.04.042","article-title":"Phlegmasia cerulea dolens in the upper extremity: a case report and literature review","volume":"76","author":"Zhang","year":"2021","journal-title":"Ann Vasc Surg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1016\/j.jhsa.2009.08.003","article-title":"Upper extremity compartment syndrome in the setting of deep venous thrombosis and phlegmasia cerulea dolens: case report","volume":"34","author":"Bedri","year":"2009","journal-title":"J Hand Surg Am"},{"key":"B3","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1177\/1538574416631645","article-title":"Phlegmasia cerulea dolens in the upper extremity: a case report and systematic review and outcomes analysis","volume":"50","author":"Greenberg","year":"2016","journal-title":"Vasc Endovascular Surg"},{"key":"B4","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1097\/00000637-200045060-00013","article-title":"Phlegmasia cerulea dolens of the upper extremity","volume":"45","author":"Bolitho","year":"2000","journal-title":"Ann Plast Surg"},{"key":"B5","first-page":"551","article-title":"Upper extremity venous gangrene following coronary artery bypass. 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