{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:50:45Z","timestamp":1753890645180,"version":"3.41.2"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There are some functional bradyarrhythmias that are caused by a dysregulation of the autonomic nervous system, for which a therapeutic strategy of cardioneuroablation (CNA) is conceivable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case summary<\/jats:title><jats:p>In this study, we report the case of a 19-year-old woman with a non-congenital third-degree atrioventricular block (AVB), symptomatic for lipothymia and dyspnea caused by mild exertion. She had a structurally normal heart and no other comorbidities. The atropine test and the exercise stress test documented a sinus tachycardia at 190\u2005bpm with a 2:1 AVB, a narrow QRS, and an atrioventricular conduction of 1:1 until reaching a sinus rhythm rate of 90\u2005bpm. She underwent the CNA procedure, which targeted the inferior paraseptal ganglion plexus, with a gradual change in the ECG levels recorded during the radiofrequency delivery from a third-degree AVB to a first-degree AVB. After the procedure, we observed a complete regression of the third-degree AVB, with evidence of only a first-degree AVB and a complete regression of symptoms until the 6-month follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although not yet included in current guidelines, the CNA procedure could be used to treat AV node dysfunction in young subjects, as it could represent an alternative to pacemaker implantation. However, more randomized studies are needed to assess the long-term efficacy of this promising technique.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2024.1370522","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T04:55:06Z","timestamp":1712120106000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["A case report of cardiac neuromodulation in a young patient with a third-degree atrioventricular block"],"prefix":"10.3389","volume":"11","author":[{"given":"Noemi","family":"Valenti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Di Monaco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imma","family":"Romanazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Vitulano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Troisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Quadrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Grimaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"euad033","DOI":"10.1093\/europace\/euad033","article-title":"Clinical controversy: methodology and indications of cardioneuroablation for reflex syncope","volume":"25","author":"Brignole","year":"2023","journal-title":"Europace"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-023-01489-w","article-title":"Quality of life improvement following cardioneuroablation for vasovagal syncope: expected or too early to say?","author":"Soni","year":"2023","journal-title":"J Interv Card Electrophysiol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jacep.2022.08.011","article-title":"Cardioneuroablation for reflex syncope: efficacy and effects on autonomic cardiac regulation\u2014a prospective randomized trial","volume":"9","author":"Piotrowski","year":"2023","journal-title":"JACC Clin Electrophysiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1016\/j.hrthm.2022.06.017","article-title":"Cardioneuroablation for vasovagal syncope: a systematic review and meta-analysis","volume":"19","author":"Vandenberk","year":"2022","journal-title":"Heart Rhythm"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1093\/cvr\/cvab172","article-title":"Neuroscientific therapies for atrial fibrillation","volume":"117","author":"Hanna","year":"2021","journal-title":"Cardiovasc Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.repc.2023.02.012","article-title":"Cardioneuroablation for severe neurocardiogenic syncope","volume":"42","author":"Santos Silva","year":"2023","journal-title":"Rev Port Cardiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"euad170","DOI":"10.1093\/europace\/euad170","article-title":"Computed tomography-based identification of ganglionated plexi to guide cardioneuroablation for vasovagal syncope","volume":"25","author":"Francia","year":"2023","journal-title":"Europace"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e02","DOI":"10.15420\/aer.2022.37","article-title":"Ganglionic plexus ablation: a step-by-step guide for electrophysiologists and review of modalities for neuromodulation for the management of atrial fibrillation","volume":"12","author":"Aksu","year":"2023","journal-title":"Arrhythm Electrophysiol Rev"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e18","DOI":"10.15420\/aer.2023.02","article-title":"Cardioneuroablation for treating vasovagal syncope: current status and future directions","volume":"12","author":"Li","year":"2023","journal-title":"Arrhythm Electrophysiol Rev"},{"key":"B10","doi-asserted-by":"publisher","first-page":"238","DOI":"10.3390\/jcdd10060238","article-title":"Cardioneuroablation using epicardial pulsed field ablation for the treatment of atrial fibrillation","volume":"10","author":"O\u2019Brien","year":"2023","journal-title":"J Cardiovas. Dev Dis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/j.hrthm.2023.06.007","article-title":"Clinical impact of aging on outcomes of cardioneuroablation for reflex syncope or functional bradycardia: results from the cardionEuroabLation: patiEnt selection, imaGe integrAtioN and outComEs\u2014the ELEGANCE multicenter study","volume":"20","author":"Francia","year":"2023","journal-title":"Heart Rhythm"},{"key":"B12","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1111\/j.1540-8159.2006.00340.x","article-title":"Syncopal high-degree AV block treated with catheter RF ablation without pacemaker implantation","volume":"29","author":"Pachon","year":"2006","journal-title":"Pacing Clin Electrophysiol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e010018","DOI":"10.1161\/CIRCEP.121.010018","article-title":"Cardioneuroablation for treatment of atrioventricular block","volume":"14","author":"Aksu","year":"2021","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/j.jacep.2023.01.032","article-title":"Long-term outcome of cardiac denervation procedures","volume":"9","author":"Rivarola","year":"2023","journal-title":"JACC Clin Electrophysiol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3390\/biology13020105","article-title":"The intrinsic cardiac nervous system: from pathophysiology to therapeutic implications","volume":"13","author":"Giannino","year":"2024","journal-title":"Biology (Basel)"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3427","DOI":"10.1093\/eurheartj\/ehab364","article-title":"2021 ESC guidelines on cardiac pacing and cardiac resynchronization therapy","volume":"42","author":"Glikson","year":"2021","journal-title":"Eur Heart J"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1370522\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T04:55:08Z","timestamp":1712120108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1370522\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,3]]},"references-count":16,"alternative-id":["10.3389\/fcvm.2024.1370522"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2024.1370522","relation":{},"ISSN":["2297-055X"],"issn-type":[{"type":"electronic","value":"2297-055X"}],"subject":[],"published":{"date-parts":[[2024,4,3]]},"article-number":"1370522"}}