{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:45:11Z","timestamp":1783529111753,"version":"3.55.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The presence of cerebral-cardiac syndrome, wherein brain diseases coincide with heart dysfunction, significantly impacts patient prognosis. In severe instances, circulatory failure may ensue, posing a life-threatening scenario necessitating immediate life support measures, particularly effective circulatory support methods. The application of extracorporeal membrane oxygenation (ECMO) is extensively employed as a valuable modality for delivering circulatory and respiratory support in the care of individuals experiencing life-threatening circulatory and respiratory failure. This approach facilitates a critical temporal window for subsequent interventions. Consequently, ECMO has emerged as a potentially effective life support modality for patients experiencing severe circulatory failure in the context of cerebral-cardiac syndrome. However, the existing literature on this field of study remains limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case description<\/jats:title><jats:p>In this paper, we present a case study of a patient experiencing a critical cerebral-cardiac syndrome. The individual successfully underwent veno-arterial-ECMO (VA-ECMO) therapy, and the patient not only survived, but also received rehabilitation treatment, demonstrating its efficacy as a life support intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>VA-ECMO could potentially serve as an efficacious life support modality for individuals experiencing severe circulatory failure attributable to cerebral-cardiac syndrome.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2024.1370696","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T12:48:50Z","timestamp":1712839730000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["A case report of successful rescue using veno-arterial extracorporeal membrane oxygenation: managing cerebral-cardiac syndrome"],"prefix":"10.3389","volume":"11","author":[{"given":"Zheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Xia","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hui","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang-Long","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"B1","first-page":"3954","article-title":"Characteristic changes in estradiol and leptin levels in patients with subarachnoid hemorrhage induced cerebral-cardiac syndrome","volume":"18","author":"Huang","year":"2014","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B2","first-page":"3737","article-title":"Comparison of cerebral-cardiac syndrome caused by nonaneurysmal or aneurysmal subarachnoid hemorrhage","volume":"18","author":"Huang","year":"2014","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1097\/MAT.0000000000001510","article-title":"ELSO interim guidelines for venoarterial extracorporeal membrane oxygenation in adult cardiac patients","volume":"67","author":"Lorusso","year":"2021","journal-title":"ASAIO J"},{"key":"B4","doi-asserted-by":"publisher","first-page":"6417012","DOI":"10.1155\/2017\/6417012","article-title":"A case of MDMA-associated cerebral and pulmonary edema requiring ECMO","volume":"2017","author":"Thakkar","year":"2017","journal-title":"Case Rep Crit Care"},{"key":"B5","doi-asserted-by":"publisher","first-page":"962","DOI":"10.3346\/jkms.2013.28.6.962","article-title":"Extracorporeal membrane oxygenation for acute life-threatening neurogenic pulmonary edema following rupture of an intracranial aneurysm","volume":"28","author":"Hwang","year":"2013","journal-title":"J Korean Med Sci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/0002-8703(47)90025-2","article-title":"Electrocardiograms with large, upright T waves and long Q-T intervals","volume":"33","author":"Byer","year":"1947","journal-title":"Am Heart J"},{"key":"B7","first-page":"1061","article-title":"Relation of brain-heart syndrome occurring time with its duration and clinical outcome in acute ischemic stroke patients","volume":"18","author":"Li","year":"2016","journal-title":"Chin J Geriatr Heart Brain Ves Dis"},{"key":"B8","doi-asserted-by":"publisher","first-page":"953","DOI":"10.3760\/cma.j.issn.2095-4352.2019.08.008","article-title":"Clinical characteristics and prognosis of brain-heart interaction in patients with acute severe stroke","volume":"31","author":"Chen","year":"2019","journal-title":"Chin Crit Care Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1161\/STROKEAHA.106.471813","article-title":"Predictors of early cardiac morbidity and mortality after ischemic stroke","volume":"38","author":"Prosser","year":"2007","journal-title":"Stroke"},{"key":"B10","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.cjca.2015.03.022","article-title":"The case against using hypertension as the only criterion for oral anticoagulation in atrial fibrillation","volume":"31","author":"Rabkin","year":"2015","journal-title":"Can J Cardiol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"175","DOI":"10.5603\/AIT.2015.0017","article-title":"Neurogenic stunned myocardium\u2014do we consider this diagnosis in patients with acute central nervous system injury and acute heart failure?","volume":"47","author":"Mierzewska-Schmidt","year":"2015","journal-title":"Anaesthesiol Intensive Ther"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1016\/j.jacc.2020.10.009","article-title":"Post-stroke cardiovascular complications and neurogenic cardiac injury: JACC state-of-the-art review","volume":"76","author":"Sposato","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"329","DOI":"10.5005\/jp-journals-10071-23208","article-title":"Head rules over the heart: cardiac manifestations of cerebral disorders","volume":"23","author":"Hrishi","year":"2019","journal-title":"Indian J Crit Care Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"3911","DOI":"10.1113\/JP271870","article-title":"Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics","volume":"594","author":"Shivkumar","year":"2016","journal-title":"J Physiol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"20150181","DOI":"10.1098\/rsta.2015.0181","article-title":"Brain-heart interactions: physiology and clinical implications","volume":"374","author":"Silvani","year":"2016","journal-title":"Philos Trans A Math Phys Eng Sci"},{"key":"B16","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1161\/CIRCRESAHA.116.308446","article-title":"Heart-brain axis: effects of neurologic injury on cardiovascular function","volume":"120","author":"Tahsili-Fahadan","year":"2017","journal-title":"Circ Res"},{"key":"B17","doi-asserted-by":"publisher","first-page":"120106","DOI":"10.1016\/j.lfs.2021.120106","article-title":"Catecholamine-induced cardiotoxicity: a critical element in the pathophysiology of stroke-induced heart injury","volume":"287","author":"Du","year":"2021","journal-title":"Life Sci"},{"key":"B18","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1007\/s11910-019-0999-7","article-title":"Neurogenic stunned myocardium in severe neurological injury","volume":"19","author":"Kenigsberg","year":"2019","journal-title":"Curr Neurol Neurosci Rep"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18020676","article-title":"Cortisol on circadian rhythm and its effect on cardiovascular system","volume":"18","author":"Mohd Azmi","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"B20","first-page":"1341","article-title":"Research progress of brain heart syndrome","volume":"16","author":"Liu","year":"2007","journal-title":"Chin J Emerg Med"},{"key":"B21","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1161\/CIRCRESAHA.117.311170","article-title":"Brain-heart interaction: cardiac complications after stroke","volume":"121","author":"Chen","year":"2017","journal-title":"Circ Res"},{"key":"B22","first-page":"443","article-title":"Mechanism and treatment of brain heart syndrome","volume":"50","author":"Ji","year":"2019","journal-title":"Prog Physiol Sci"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.3389\/fimmu.2020.01534","article-title":"Cytotoxicity of donor natural killer cells to allo-reactive T cells are related with acute graft-vs.-host-disease following allogeneic stem cell transplantation","volume":"11","author":"Sheng","year":"2020","journal-title":"Front Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1186\/s13054-020-02885-8","article-title":"Brain-heart interaction after acute ischemic stroke","volume":"24","author":"Battaglini","year":"2020","journal-title":"Crit Care"},{"key":"B25","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1089\/neu.2018.5766","article-title":"Immune response mediates cardiac dysfunction after traumatic brain injury","volume":"36","author":"Zhao","year":"2019","journal-title":"J Neurotrauma"},{"key":"B26","doi-asserted-by":"publisher","first-page":"113209","DOI":"10.1016\/j.expneurol.2020.113209","article-title":"Spleen associated immune-response mediates brain-heart interaction after intracerebral hemorrhage","volume":"327","author":"Li","year":"2020","journal-title":"Exp Neurol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"598","DOI":"10.3389\/fneur.2020.00598","article-title":"Gut microbiota in acute ischemic stroke: from pathophysiology to therapeutic implications","volume":"11","author":"Battaglini","year":"2020","journal-title":"Front Neurol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.cell.2016.02.011","article-title":"Gut microbial metabolite TMAO enhances platelet hyperreactivity and thrombosis risk","volume":"165","author":"Zhu","year":"2016","journal-title":"Cell"},{"key":"B29","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1161\/STROKEAHA.111.642199","article-title":"A structured reading algorithm improves telemetric detection of atrial fibrillation after acute ischemic stroke","volume":"43","author":"Kallm\u00fcnzer","year":"2012","journal-title":"Stroke"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol Rev"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1161\/ATVBAHA.118.311023","article-title":"Gut microbiota-dependent trimethylamine N-oxide predicts risk of cardiovascular events in patients with stroke and is related to proinflammatory monocytes","volume":"38","author":"Haghikia","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/1471-2377-13-178","article-title":"Circulating miR-30a, miR-126 and let-7b as biomarker for ischemic stroke in humans","volume":"13","author":"Long","year":"2013","journal-title":"BMC Neurol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"113382","DOI":"10.1016\/j.expneurol.2020.113382","article-title":"Emerging role of microRNAs in ischemic stroke with comorbidities","volume":"331","author":"Qian","year":"2020","journal-title":"Exp Neurol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1007\/s12975-017-0520-z","article-title":"MiR-126 affects brain-heart interaction after cerebral ischemic stroke","volume":"8","author":"Chen","year":"2017","journal-title":"Transl Stroke Res"},{"key":"B35","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1007\/s00134-008-1357-4","article-title":"Intravascular cooling for rapid induction of moderate hypothermia in severely head-injured patients: results of a multicenter study (IntraCool)","volume":"35","author":"Sahuquillo","year":"2009","journal-title":"Intensive Care Med"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1370696\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T12:48:59Z","timestamp":1712839739000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1370696\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,11]]},"references-count":35,"alternative-id":["10.3389\/fcvm.2024.1370696"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2024.1370696","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,11]]},"article-number":"1370696"}}