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Currently, more research and developments are required to identify different treatment modalities to reduce hospitalization rates and improve the quality of life of patients with HF. In relation to this, various non-valvular catheter-based therapies have been recently developed for managing chronic HF. These devices target the pathophysiological processes involved in HF development including neurohumoral activation, congestion, and left ventricular remodeling. The present review article aimed to discuss the major transcatheter devices used in managing chronic HF. The rationale and current clinical developmental stages of these interventions will also be addressed in this review.<\/jats:p>","DOI":"10.3389\/fcvm.2024.1388232","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T04:45:39Z","timestamp":1729226739000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Device therapies for heart failure with reduced ejection fraction: a new era"],"prefix":"10.3389","volume":"11","author":[{"given":"Rohit","family":"Mody","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abha Bajaj","family":"Nee Sheth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debabrata","family":"Dash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavya","family":"Mody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inderjeet Singh","family":"Monga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshay","family":"Rastogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Munjal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.4244\/EIJ-D-22-00070","article-title":"Transcatheter interventions for heart failure","volume":"18","author":"Latib","year":"2023","journal-title":"EuroIntervention"},{"key":"B2","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1002\/ejhf.2115","article-title":"Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure: endorsed by the Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and Chinese Heart Failure Association","volume":"23","author":"Bozkurt","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"B3","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.amjcard.2022.02.037","article-title":"Secular trends in prevalence of heart failure diagnosis over 20 years (from the US NHANES)","volume":"172","author":"Siontis","year":"2022","journal-title":"Am J Cardiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.jchf.2017.12.006","article-title":"Innovation in heart failure treatment: life expectancy, disability, and health disparities","volume":"6","author":"Van Nuys","year":"2018","journal-title":"JACC Heart Fail"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the global burden of disease study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"B6","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","article-title":"Global burden of heart failure: a comprehensive and updated review of epidemiology","volume":"118","author":"Savarese","year":"2023","journal-title":"Cardiovasc Res"},{"key":"B7","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1001\/jamacardio.2020.7472","article-title":"National trends in heart failure hospitalizations and readmissions from 2010 to 2017","volume":"6","author":"Agarwal","year":"2021","journal-title":"JAMA Cardiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e139","DOI":"10.1161\/cir.0000000000000757","article-title":"Heart disease and stroke statistics\u20142020 update: a report from the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e880","DOI":"10.1002\/hsr2.880","article-title":"Endocrine hormone imbalance in heart failure with reduced ejection fraction: a cross-sectional study","volume":"5","author":"N\u00e4gele","year":"2022","journal-title":"Health Sci. 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