{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:07:31Z","timestamp":1787947651970,"version":"build-2784847793"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Postoperative delirium (POD) is a common anesthetic side effect in cardiac surgery. However, the role of oxygen saturation monitoring in reducing postoperative delirium has been controversial. Therefore, this meta-analysis aimed to analyze whether NIRS monitoring during cardiac surgery under cardiopulmonary bypass could reduce the incidence of postoperative delirium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, Web of Science, Cochrane Library, Embase and China National Knowledge Infrastructure (CNKI) databases were systematically searched using the related keywords for randomized-controlled trials (RCTs) published from their inception to March 16, 2024. This review was conducted by the Preferred Reporting Project and Meta-Analysis Statement (PRISMA) guidelines for systematic review. The primary outcome was postoperative delirium, and the second outcomes included the length of ICU stay, the incidence of kidney-related adverse outcomes, and the incidence of cardiac-related adverse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of postoperative delirium could be reduced under the guidance of near-infrared spectroscopy monitoring (OR, 0.657; 95% CI, 0.447\u20130.965; <jats:italic>P<\/jats:italic>\u2009=\u20090.032; I<jats:sup>2<\/jats:sup>\u2009=\u20090%). However, there were no significant differences in the length of ICU stay (SMD, 0.005 days; 95% CI, \u22120.135\u20130.146; <jats:italic>P<\/jats:italic>\u2009=\u20090.940; I<jats:sup>2<\/jats:sup>\u2009=\u200939.3%), the incidence of kidney-related adverse outcomes (OR, 0.761; 95% CI, 0.386\u20131.500; <jats:italic>P<\/jats:italic>\u2009=\u20090.430; I<jats:sup>2<\/jats:sup>\u2009=\u20090%), and the incidence of the cardiac-related adverse outcomes (OR, 1.165; 95% CI, 0.556\u20132.442; <jats:italic>P<\/jats:italic>\u2009=\u20090.686; I<jats:sup>2<\/jats:sup>\u2009=\u20090%) between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Near-infrared spectroscopy monitoring in cardiac surgery with cardiopulmonary bypass helps reduce postoperative delirium in patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic Review Registration<\/jats:title><jats:p>PROSPERO, identifier, CRD42023482675<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2024.1404210","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T05:29:12Z","timestamp":1718688552000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of near-infrared spectroscopy on postoperative delirium in cardiac surgery with cardiopulmonary bypass: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"11","author":[{"given":"Qian","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1016\/S0140-6736(98)07576-X","article-title":"Neurobehavioural sequelae of cardiopulmonary 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