{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:26:22Z","timestamp":1791915982229,"version":"4.3.4"},"reference-count":207,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>The incidence of aortic dissection (AD) is steadily increasing, driven by the rising prevalence of chronic conditions such as hypertension and the global aging of the population. Oxidative stress emerges as a pivotal pathophysiological mechanism contributing to the progression of AD. Oxidative stress triggers apoptosis in vascular smooth muscle cells, reshapes the extracellular matrix (ECM), and governs ECM degradation and remodeling, subsequently impacting aortic compliance. Furthermore, oxidative stress not only facilitates the infiltration of macrophages and mononuclear lymphocytes but also disrupts the integral structure and functionality of endothelial cells, thereby inducing endothelial cell dysfunction and furthering the degeneration of the middle layer of the aortic wall. Investigating antioxidants holds promise as a therapeutic avenue for addressing AD.<\/jats:p>","DOI":"10.3389\/fcvm.2024.1410477","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:57:03Z","timestamp":1720745823000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["The role of oxidative stress in aortic dissection: a potential therapeutic target"],"prefix":"10.3389","volume":"11","author":[{"given":"Shengnan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiukun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/S0140-6736(14)61005-9","article-title":"Management of acute aortic dissection","volume":"385","author":"Nienaber","year":"2015","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/s41569-020-00472-6","article-title":"Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes","volume":"18","author":"Bossone","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1053\/j.semvascsurg.2021.02.003","article-title":"Epidemiology of aortic dissection","volume":"34","author":"Sen","year":"2021","journal-title":"Semin Vasc Surg"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1161\/CIRCULATIONAHA.117.031264","article-title":"Insights from the international registry of acute aortic dissection: a 20-year experience of collaborative clinical research","volume":"137","author":"Evangelista","year":"2018","journal-title":"Circulation"},{"key":"B5","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1161\/CIRCULATIONAHA.121.056546","article-title":"Blood pressure, hypertension, and the risk of aortic dissection incidence and mortality: results from the J-SCH study, the UK biobank study, and a meta-analysis of cohort studies","volume":"145","author":"Hibino","year":"2022","journal-title":"Circulation"},{"key":"B6","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","article-title":"Targeting oxidative stress in disease: promise and limitations of antioxidant therapy","volume":"20","author":"Forman","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.3390\/nu11092090","article-title":"Oxidative stress in cardiovascular diseases: still a therapeutic target?","volume":"11","author":"Senoner","year":"2019","journal-title":"Nutrients"},{"key":"B8","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1002\/ejhf.1320","article-title":"Treating oxidative stress in heart failure: past, present and future","volume":"21","author":"van der Pol","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"B9","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s12933-017-0604-9","article-title":"Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes","volume":"16","author":"Karam","year":"2017","journal-title":"Cardiovasc Diabetol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3389\/fcvm.2018.00107","article-title":"Genetic alterations in oxidant and anti-oxidant enzymes in the vascular system","volume":"5","author":"Awad","year":"2018","journal-title":"Front Cardiovasc Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.1161\/CIRCULATIONAHA.113.005062","article-title":"Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection","volume":"129","author":"Fan","year":"2014","journal-title":"Circulation"},{"key":"B12","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1161\/CIRCRESAHA.117.311401","article-title":"Reactive oxygen species in metabolic and inflammatory signaling","volume":"122","author":"Forrester","year":"2018","journal-title":"Circ Res"},{"key":"B13","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1161\/01.RES.87.10.840","article-title":"Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress","volume":"87","author":"Cai","year":"2000","journal-title":"Circ Res"},{"key":"B14","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol Rev"},{"key":"B15","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/s41569-019-0260-8","article-title":"NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets","volume":"17","author":"Zhang","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.3390\/cells10081947","article-title":"Human vascular smooth muscle function and oxidative stress induced by NADPH oxidase with the clinical implications","volume":"10","author":"Takaishi","year":"2021","journal-title":"Cells-Basel"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1161\/01.RES.0000263381.83835.7b","article-title":"Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice","volume":"100","author":"Bendall","year":"2007","journal-title":"Circ Res"},{"key":"B18","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.tips.2013.03.007","article-title":"Oxidative stress in vascular disease and its pharmacological prevention","volume":"34","author":"Li","year":"2013","journal-title":"Trends Pharmacol Sci"},{"key":"B19","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.freeradbiomed.2010.12.018","article-title":"Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders","volume":"50","author":"Gielis","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"B20","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/1476-4598-12-86","article-title":"The complexity of NF-\u03baB signaling in inflammation and cancer","volume":"12","author":"Hoesel","year":"2013","journal-title":"Mol Cancer"},{"key":"B21","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"B22","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/nri910","article-title":"NF-kappaB regulation in the immune system","volume":"2","author":"Li","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-\u03baB signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1161\/CIRCRESAHA.108.182097","article-title":"p21-activated kinase signaling regulates oxidant-dependent NF-kappa B activation by flow","volume":"103","author":"Orr","year":"2008","journal-title":"Circ Res"},{"key":"B25","doi-asserted-by":"publisher","first-page":"126704","DOI":"10.1016\/j.jhazmat.2021.126704","article-title":"Cadmium exposure triggers oxidative stress, necroptosis, Th1\/Th2 imbalance and promotes inflammation through the TNF-\u03b1\/NF-\u03baB pathway in swine small intestine","volume":"421","author":"Chen","year":"2022","journal-title":"J Hazard Mater"},{"key":"B26","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1093\/cvr\/cvu112","article-title":"TNF-\u03b1-mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes","volume":"103","author":"Roberge","year":"2014","journal-title":"Cardiovasc Res"},{"key":"B27","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.tcb.2015.12.002","article-title":"TNF and ROS crosstalk in inflammation","volume":"26","author":"Blaser","year":"2016","journal-title":"Trends Cell Biol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.biopha.2017.03.062","article-title":"NLRC5 Deficiency promotes myocardial damage induced by high fat diet in mice through activating TLR4\/NF-\u03baB","volume":"91","author":"Ma","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"B29","doi-asserted-by":"publisher","first-page":"101186","DOI":"10.1016\/j.redox.2019.101186","article-title":"TLR4 participates in sympathetic hyperactivity post-MI in the PVN by regulating NF-\u03baB pathway and ROS production","volume":"24","author":"Wang","year":"2019","journal-title":"Redox Biol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"3731","DOI":"10.3390\/molecules24203731","article-title":"Chlojaponilactone B attenuates lipopolysaccharide-induced inflammatory responses by suppressing TLR4-mediated ROS generation and NF-\u03baB signaling pathway","volume":"24","author":"Ye","year":"2019","journal-title":"Molecules"},{"key":"B31","doi-asserted-by":"publisher","first-page":"124050","DOI":"10.1016\/j.jhazmat.2020.124050","article-title":"Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1\/TLR4\/MYD88\/NF-kb signaling pathway in HUVEC cells","volume":"404","author":"Liu","year":"2021","journal-title":"J Hazard Mater"},{"key":"B32","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat Immunol"},{"key":"B33","first-page":"31","article-title":"Nuclear factor-kappaB: activation and regulation during toll-like receptor signaling","volume":"4","author":"Carmody","year":"2007","journal-title":"Cell Mol Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2522","DOI":"10.4049\/jimmunol.172.4.2522","article-title":"Involvement of reactive oxygen species in toll-like receptor 4-dependent activation of NF-kappa B","volume":"172","author":"Asehnoune","year":"2004","journal-title":"J Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.freeradbiomed.2013.06.020","article-title":"Bidirectional regulation of NF-\u03baB by reactive oxygen species: a role of unfolded protein response","volume":"65","author":"Nakajima","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"B36","doi-asserted-by":"publisher","first-page":"13086","DOI":"10.1073\/pnas.0603290103","article-title":"Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta","volume":"103","author":"Reynaert","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B37","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/sj.cr.7290105","article-title":"MAPK signal pathways in the regulation of cell proliferation in mammalian cells","volume":"12","author":"Zhang","year":"2002","journal-title":"Cell Res"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1126\/science.1072682","article-title":"Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases","volume":"298","author":"Johnson","year":"2002","journal-title":"Science"},{"key":"B39","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0014-4827(03)00391-4","article-title":"Oxidative stress-induced apoptosis is mediated by ERK1\/2 phosphorylation","volume":"291","author":"Lee","year":"2003","journal-title":"Exp Cell Res"},{"key":"B40","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1161\/hc0802.104324","article-title":"Protection of human endothelial cells from oxidative stress: role of ras-ERK1\/2 signaling","volume":"105","author":"Cuda","year":"2002","journal-title":"Circulation"},{"key":"B41","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/S0960-9822(01)00159-2","article-title":"Opposing functions of ki- and ha-ras genes in the regulation of redox signals","volume":"11","author":"Santillo","year":"2001","journal-title":"Curr Biol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1158\/0008-5472.CAN-03-3361","article-title":"Reactive oxygen species (ROS), troublemakers between nuclear factor-kappaB (NF-kappaB) and c-jun NH(2)-terminal kinase (JNK)","volume":"64","author":"Zhang","year":"2004","journal-title":"Cancer Res"},{"key":"B43","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1146\/annurev.pharmtox.48.113006.094606","article-title":"Apoptosis signal-regulating kinase 1 in stress and immune response","volume":"48","author":"Takeda","year":"2008","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1161\/01.RES.0000130525.37646.a7","article-title":"Thioredoxin-2 inhibits mitochondria-located ASK1-mediated apoptosis in a JNK-independent manner","volume":"94","author":"Zhang","year":"2004","journal-title":"Circ Res"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1007\/s00204-013-1034-4","article-title":"Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis","volume":"87","author":"Sinha","year":"2013","journal-title":"Arch Toxicol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"11706","DOI":"10.1074\/jbc.275.16.11706","article-title":"Src and Cas mediate JNK activation but not ERK1\/2 and p38 kinases by reactive oxygen species","volume":"275","author":"Yoshizumi","year":"2000","journal-title":"J Biol Chem"},{"key":"B47","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/sj.cdd.4401865","article-title":"The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease","volume":"13","author":"Papa","year":"2006","journal-title":"Cell Death Differ"},{"key":"B48","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"B49","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/s41573-018-0008-x","article-title":"Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases","volume":"18","author":"Cuadrado","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"B50","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.freeradbiomed.2011.04.022","article-title":"Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo","volume":"51","author":"Brewer","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"B51","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1089\/ars.2016.6795","article-title":"Nuclear factor (erythroid-derived 2)-like 2 and thioredoxin-1 in atherosclerosis and ischemia\/reperfusion injury in the heart","volume":"26","author":"Jakobs","year":"2017","journal-title":"Antioxid Redox Signal"},{"key":"B52","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3390\/diseases4040034","article-title":"The role of the Nrf2\/ARE antioxidant system in preventing cardiovascular diseases","volume":"4","author":"Smith","year":"2016","journal-title":"Diseases"},{"key":"B53","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1002\/med.21396","article-title":"The Keap1-Nrf2-ARE pathway as a potential preventive and therapeutic target: an update","volume":"36","author":"Lu","year":"2016","journal-title":"Med Res Rev"},{"key":"B54","doi-asserted-by":"publisher","first-page":"637","DOI":"10.14336\/AD.2018.0513","article-title":"The anti-inflammatory and anti-oxidant mechanisms of the Keap1\/Nrf2\/ARE signaling pathway in chronic diseases","volume":"10","author":"Tu","year":"2019","journal-title":"Aging Dis"},{"key":"B55","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.apsb.2015.05.008","article-title":"Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents","volume":"5","author":"Abed","year":"2015","journal-title":"Acta Pharm Sin B"},{"key":"B56","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1042\/BST20150014","article-title":"Dissecting molecular cross-talk between Nrf2 and NF-\u03baB response pathways","volume":"43","author":"Wardyn","year":"2015","journal-title":"Biochem Soc Trans"},{"key":"B57","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.molcel.2017.05.032","article-title":"AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance","volume":"66","author":"Garcia","year":"2017","journal-title":"Mol Cell"},{"key":"B59","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nature11066","article-title":"AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress","volume":"485","author":"Jeon","year":"2012","journal-title":"Nature"},{"key":"B60","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.metabol.2018.03.004","article-title":"Activation of AMPK inhibits inflammatory response during hypoxia and reoxygenation through modulating JNK-mediated NF-\u03baB pathway","volume":"83","author":"Chen","year":"2018","journal-title":"Metab Clin Exp"},{"key":"B61","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1016\/j.molcel.2021.03.018","article-title":"Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression","volume":"81","author":"van Vliet","year":"2021","journal-title":"Mol Cell"},{"key":"B62","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/s41401-022-00966-8","article-title":"SZC-6, a small-molecule activator of SIRT3, attenuates cardiac hypertrophy in mice","volume":"44","author":"Li","year":"2023","journal-title":"Acta Pharmacol Sin"},{"key":"B63","doi-asserted-by":"publisher","first-page":"675647","DOI":"10.3389\/fcvm.2021.675647","article-title":"Sirt3 protects against thoracic aortic dissection formation by reducing reactive oxygen species, vascular inflammation, and apoptosis of smooth muscle cells","volume":"8","author":"Qiu","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"B64","doi-asserted-by":"publisher","first-page":"16053","DOI":"10.1038\/nrdp.2016.53","article-title":"Aortic dissection","volume":"2","author":"Nienaber","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"B65","doi-asserted-by":"publisher","first-page":"24","DOI":"10.14797\/mdcvj.1218","article-title":"Genetically triggered thoracic aortic disease: who should be tested?","volume":"19","author":"Duarte","year":"2023","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.3390\/biomedicines9091171","article-title":"Oxidative stress-related susceptibility to aneurysm in Marfan\u2019s syndrome","volume":"9","author":"Rysz","year":"2021","journal-title":"Biomedicines"},{"key":"B67","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1161\/ATVBAHA.118.310956","article-title":"Therapies for thoracic aortic aneurysms and acute aortic dissections","volume":"39","author":"Milewicz","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1109\/RBME.2019.2950140","article-title":"Review of current advances in the mechanical description and quantification of aortic dissection mechanisms","volume":"14","author":"Brunet","year":"2021","journal-title":"IEEE Rev Biomed Eng"},{"key":"B69","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1631\/jzus.B2000022","article-title":"Induction of thoracic aortic dissection: a mini-review of \u03b2-aminopropionitrile-related mouse models","volume":"21","author":"Zheng","year":"2020","journal-title":"J Zhejiang Univ Sci B"},{"key":"B70","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1161\/ATVBAHA.116.307211","article-title":"Ascending aortic aneurysm in angiotensin II-infused mice: formation, progression, and the role of focal dissections","volume":"36","author":"Trachet","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1016\/j.jvs.2011.10.088","article-title":"Endovascular creation of aortic dissection in a swine model with technical considerations","volume":"55","author":"Okuno","year":"2012","journal-title":"J Vasc Surg"},{"key":"B72","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1097\/01.RVI.0000151142.80319.85","article-title":"An experimental model of Stanford type B aortic dissection","volume":"16","author":"Terai","year":"2005","journal-title":"J Vasc Interv Radiol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.1161\/01.CIR.99.16.2138","article-title":"Mechanisms underlying aortic dilatation in congenital aortic valve malformation","volume":"99","author":"Bonderman","year":"1999","journal-title":"Circulation"},{"key":"B74","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1093\/cvr\/cvt205","article-title":"Oxidative stress modulates vascular smooth muscle cell phenotype via CTGF in thoracic aortic aneurysm","volume":"100","author":"Branchetti","year":"2013","journal-title":"Cardiovasc Res"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.3390\/antiox11101958","article-title":"Roles of oxidative stress and inflammation in vascular endothelial dysfunction-related disease","volume":"11","author":"Higashi","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"B76","doi-asserted-by":"publisher","first-page":"e13697","DOI":"10.1111\/eci.13697","article-title":"The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections","volume":"52","author":"Rombouts","year":"2022","journal-title":"Eur J Clin Invest"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1038\/s41374-018-0032-9","article-title":"Redox control of vascular smooth muscle cell function and plasticity","volume":"98","author":"Durgin","year":"2018","journal-title":"Lab Invest"},{"key":"B78","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1093\/cvr\/cvr308","article-title":"Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration","volume":"93","author":"Jagadeesha","year":"2012","journal-title":"Cardiovasc Res"},{"key":"B79","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.redox.2016.08.015","article-title":"Redox signaling in cardiovascular pathophysiology: a focus on hydrogen peroxide and vascular smooth muscle cells","volume":"9","author":"Byon","year":"2016","journal-title":"Redox Biol"},{"key":"B80","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.bioactmat.2022.04.033","article-title":"A TEMPOL and rapamycin loaded nanofiber-covered stent favors endothelialization and mitigates neointimal hyperplasia and local inflammation","volume":"19","author":"Wang","year":"2023","journal-title":"Bioact Mater"},{"key":"B81","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1161\/HYPERTENSIONAHA.107.089706","article-title":"NOX1 deficiency protects from aortic dissection in response to angiotensin II","volume":"50","author":"Gavazzi","year":"2007","journal-title":"Hypertension"},{"key":"B82","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1161\/ATVBAHA.120.315322","article-title":"Fibroblast Nox2 (NADPH oxidase-2) regulates ANG II (angiotensin II)-induced vascular remodeling and hypertension via paracrine signaling to vascular smooth muscle cells","volume":"41","author":"Harrison","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.1161\/CIRCULATIONAHA.105.538934","article-title":"Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice","volume":"112","author":"Dikalova","year":"2005","journal-title":"Circulation"},{"key":"B84","doi-asserted-by":"publisher","first-page":"e117","DOI":"10.1161\/ATVBAHA.121.317239","article-title":"NADPH oxidase 1 mediates acute blood pressure response to angiotensin II by contributing to calcium influx in vascular smooth muscle cells","volume":"42","author":"Park","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1016\/j.jtcvs.2013.09.060","article-title":"BRCA1 shields vascular smooth muscle cells from oxidative stress","volume":"147","author":"Lovren","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B86","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1248\/bpb.b18-01012","article-title":"NOX1 negatively modulates fibulin-5 in vascular smooth muscle cells to affect aortic dissection","volume":"42","author":"Hu","year":"2019","journal-title":"Biol Pharm Bull"},{"key":"B87","doi-asserted-by":"publisher","first-page":"165912","DOI":"10.1016\/j.bbadis.2020.165912","article-title":"Smooth muscle NADPH oxidase 4 promotes angiotensin II-induced aortic aneurysm and atherosclerosis by regulating osteopontin","volume":"1866","author":"Yu","year":"2020","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B88","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1161\/CIRCRESAHA.109.193722","article-title":"Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells","volume":"105","author":"Lyle","year":"2009","journal-title":"Circ Res"},{"key":"B89","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.freeradbiomed.2018.02.023","article-title":"Redox stress in Marfan syndrome: dissecting the role of the NADPH oxidase NOX4 in aortic aneurysm","volume":"118","author":"Jim\u00e9nez-Altay\u00f3","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"B90","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1161\/CIRCRESAHA.119.316159","article-title":"Reactive oxygen-forming Nox5 links vascular smooth muscle cell phenotypic switching and extracellular vesicle-mediated vascular calcification","volume":"127","author":"Furmanik","year":"2020","journal-title":"Circ Res"},{"key":"B91","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1093\/cvr\/cvab171","article-title":"Central role of c-src in NOX5- mediated redox signalling in vascular smooth muscle cells in human hypertension","volume":"118","author":"Camargo","year":"2022","journal-title":"Cardiovasc ReS"},{"key":"B92","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/S0008-6363(00)00137-1","article-title":"eNOS gene transfer to vascular smooth muscle cells inhibits cell proliferation via upregulation of p27 and p21 and not apoptosis","volume":"47","author":"Sato","year":"2000","journal-title":"Cardiovasc Res"},{"key":"B93","doi-asserted-by":"publisher","first-page":"C191","DOI":"10.1152\/ajpcell.00179.2002","article-title":"Mechanism of eNOS gene transfer inhibition of vascular smooth muscle cell proliferation","volume":"284","author":"D\u2019Souza","year":"2003","journal-title":"Am J Physiol Cell Physiol"},{"key":"B94","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1186\/s12967-022-03659-2","article-title":"Alpha-ketoglutarate ameliorates abdominal aortic aneurysm via inhibiting PXDN\/HOCL\/ERK signaling pathways","volume":"20","author":"Liu","year":"2022","journal-title":"J Transl Med"},{"key":"B95","doi-asserted-by":"publisher","first-page":"H496","DOI":"10.1152\/ajpheart.00898.2020","article-title":"Angiotensin II-induced overexpression of sirtuin 1 contributes to enhanced expression of gi\u03b1 proteins and hyperproliferation of vascular smooth muscle cells","volume":"321","author":"Hossain","year":"2021","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"e10069","DOI":"10.1161\/JAHA.118.010069","article-title":"VPO1 modulates vascular smooth muscle cell phenotypic switch by activating extracellular signal-regulated kinase 1\/2 (ERK 1\/2) in abdominal aortic aneurysms","volume":"7","author":"Peng","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"B97","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41392-021-00625-0","article-title":"CD38 deficiency alleviates ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice","volume":"6","author":"Gan","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"B98","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.3390\/jcm11051313","article-title":"Antioxidant effects of statins by modulating Nrf2 and Nrf2\/HO-1 signaling in different diseases","volume":"11","author":"Mansouri","year":"2022","journal-title":"J Clin Med"},{"key":"B99","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/s41569-023-00839-5","article-title":"The role of aldehyde dehydrogenase 2 in cardiovascular disease","volume":"20","author":"Zhang","year":"2023","journal-title":"Nat Rev Cardiol"},{"key":"B100","doi-asserted-by":"publisher","first-page":"9498","DOI":"10.1096\/fj.201902550RRR","article-title":"Aldehyde dehydrogenase 2 protects against abdominal aortic aneurysm formation by reducing reactive oxygen species, vascular inflammation, and apoptosis of vascular smooth muscle cells","volume":"34","author":"Tsai","year":"2020","journal-title":"FASEB J"},{"key":"B101","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1093\/eurheartj\/ehaa352","article-title":"Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype","volume":"41","author":"Yang","year":"2020","journal-title":"Eur Heart J"},{"key":"B102","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1016\/j.jacc.2010.01.076","article-title":"Biomarkers in acute aortic dissection and other aortic syndromes","volume":"56","author":"Ranasinghe","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"B103","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.actbio.2022.03.042","article-title":"Mechanical and histological characteristics of aortic dissection tissues","volume":"146","author":"Li","year":"2022","journal-title":"Acta Biomater"},{"key":"B104","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.1161\/CIRCULATIONAHA.109.872663","article-title":"Impaired fibrillin-1 function promotes features of plaque instability in apolipoprotein E-deficient mice","volume":"120","author":"Van Herck","year":"2009","journal-title":"Circulation"},{"key":"B105","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix in development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B106","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1056\/NEJM198103053041004","article-title":"Elastin structure, biosynthesis, and relation to disease states","volume":"304","author":"Sandberg","year":"1981","journal-title":"N Engl J Med"},{"key":"B107","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1161\/ATVBAHA.117.308199","article-title":"Tracking adventitial fibroblast contribution to disease: a review of current methods to identify resident fibroblasts","volume":"37","author":"Kuwabara","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B108","doi-asserted-by":"publisher","first-page":"e37","DOI":"10.1161\/ATVBAHA.120.313991","article-title":"Aortic aneurysms and dissections series","volume":"40","author":"Shen","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B109","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.yjmcc.2015.11.025","article-title":"Mechanical control of cardiac myofibroblasts","volume":"93","author":"Van Putten","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"B110","doi-asserted-by":"publisher","first-page":"910","DOI":"10.7150\/thno.66059","article-title":"Dysregulation of interaction between LOX(high) fibroblast and smooth muscle cells contributes to the pathogenesis of aortic dissection","volume":"12","author":"Chen","year":"2022","journal-title":"Theranostics"},{"key":"B111","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.matbio.2015.01.005","article-title":"Matrix metalloproteinase interactions with collagen and elastin","author":"Van Doren","year":"2015","journal-title":"Matrix Biol"},{"key":"B112","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.biochi.2019.07.001","article-title":"MMP-14 degrades tropoelastin and elastin","volume":"165","author":"Miekus","year":"2019","journal-title":"Biochimie"},{"key":"B113","doi-asserted-by":"publisher","first-page":"e13","DOI":"10.1161\/CIRCRESAHA.117.305108","article-title":"Deficiency of MMP17\/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice","volume":"117","author":"Mart\u00edn-Alonso","year":"2015","journal-title":"Circ Res"},{"key":"B114","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12979-016-0063-2","article-title":"Acute phase of aortic dissection: a pilot study on CD40l, MPO, and MMP-1, -2, 9 and TIMP-1 circulating levels in elderly patients","volume":"13","author":"Vianello","year":"2016","journal-title":"Immun Ageing"},{"key":"B115","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/aps.2013.179","article-title":"Association of the polymorphisms of MMP-9 and TIMP-3 genes with thoracic aortic dissection in Chinese Han population","volume":"35","author":"Wang","year":"2014","journal-title":"Acta Pharmacol Sin"},{"key":"B116","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.biopha.2018.09.129","article-title":"Mechanical stretch aggravates aortic dissection by regulating MAPK pathway and the expression of MMP-9 and inflammation factors","volume":"108","author":"Hu","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"B117","doi-asserted-by":"publisher","first-page":"116927","DOI":"10.1016\/j.lfs.2019.116927","article-title":"Targeted depletion of monocyte\/macrophage suppresses aortic dissection with the spatial regulation of MMP-9 in the aorta","volume":"254","author":"Li","year":"2020","journal-title":"Life Sci"},{"key":"B118","doi-asserted-by":"publisher","first-page":"106805","DOI":"10.1016\/j.isci.2023.106805","article-title":"Platelets reprogram monocyte functions by secreting MMP-9 to benefit postoperative outcomes following acute aortic dissection","volume":"26","author":"Shen","year":"2023","journal-title":"iScience"},{"key":"B119","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3390\/ph12030118","article-title":"Matrix metalloproteinase in abdominal aortic aneurysm and aortic dissection","volume":"12","author":"Maguire","year":"2019","journal-title":"Pharmaceuticals (Basel)"},{"key":"B120","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s10735-013-9558-8","article-title":"Angiotensin-II induces phosphorylation of ERK1\/2 and promotes aortic adventitial fibroblasts differentiating into myofibroblasts during aortic dissection formation","volume":"45","author":"Wang","year":"2014","journal-title":"J Mol Histol"},{"key":"B121","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.1161\/ATVBAHA.113.301624","article-title":"Aortic remodeling after transverse aortic constriction in mice is attenuated with AT1 receptor blockade","volume":"33","author":"Kuang","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B122","doi-asserted-by":"publisher","first-page":"928","DOI":"10.3390\/antiox11050928","article-title":"SOD3 suppresses the expression of MMP-1 and increases the integrity of extracellular matrix in fibroblasts","volume":"11","author":"Kim","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"B123","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1016\/j.freeradbiomed.2008.08.022","article-title":"4-Hydroxynonenal enhances MMP-2 production in vascular smooth muscle cells via mitochondrial ROS-mediated activation of the akt\/NF-kappaB signaling pathways","volume":"45","author":"Lee","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"B124","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.redox.2018.07.005","article-title":"Matrix metalloproteinase-2-induced epidermal growth factor receptor transactivation impairs redox balance in vascular smooth muscle cells and facilitates vascular contraction","volume":"18","author":"Prado","year":"2018","journal-title":"Redox Biol"},{"key":"B125","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1093\/cvr\/cvab300","article-title":"MMP-2 knockdown blunts age-dependent carotid stiffness by decreasing elastin degradation and augmenting eNOS activation","volume":"118","author":"Diaz-Canestro","year":"2022","journal-title":"Cardiovasc Res"},{"key":"B126","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s12989-022-00472-z","article-title":"Oxidative stress generated by polycyclic aromatic hydrocarbons from ambient particulate matter enhance vascular smooth muscle cell migration through MMP upregulation and actin reorganization","volume":"19","author":"Ju","year":"2022","journal-title":"Part Fibre Toxicol"},{"key":"B127","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1089\/ars.2015.6475","article-title":"Salusin-\u03b2 promotes vascular smooth muscle cell migration and intimal hyperplasia after vascular injury via ROS\/NF\u03baB\/MMP-9 pathway","volume":"24","author":"Sun","year":"2016","journal-title":"Antioxid Redox Signal"},{"key":"B128","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3390\/biom11040585","article-title":"Matrix metalloproteinases and arterial hypertension: role of oxidative stress and nitric oxide in vascular functional and structural alterations","volume":"11","author":"Prado","year":"2021","journal-title":"Biomolecules"},{"key":"B129","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.bbrc.2004.12.152","article-title":"Angiotensin II induces MMP-2 in a p47phox-dependent manner","volume":"328","author":"Luchtefeld","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"B130","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1161\/01.CIR.0000136995.83451.1D","article-title":"Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin\/ceramide pathway and smooth muscle cell proliferation","volume":"110","author":"Aug\u00e9","year":"2004","journal-title":"Circulation"},{"key":"B131","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.redox.2014.12.008","article-title":"Elastin aging and lipid oxidation products in human aorta","volume":"4","author":"Zarkovic","year":"2015","journal-title":"Redox Biol"},{"key":"B132","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.atherosclerosis.2018.01.031","article-title":"Quercetin decreases the activity of matrix metalloproteinase-2 and ameliorates vascular remodeling in renovascular hypertension","volume":"270","author":"Pereira","year":"2018","journal-title":"Atherosclerosis"},{"key":"B133","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.freeradbiomed.2018.11.002","article-title":"Nitrite treatment downregulates vascular MMP-2 activity and inhibits vascular remodeling in hypertension independently of its antihypertensive effects","volume":"130","author":"Rizzi","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"B134","doi-asserted-by":"publisher","first-page":"H984","DOI":"10.1152\/ajpheart.00428.2011","article-title":"Adiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling","volume":"301","author":"Essick","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B135","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1093\/cvr\/cvn173","article-title":"Insulin-like growth factor-I induces reactive oxygen species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells","volume":"80","author":"Meng","year":"2008","journal-title":"Cardiovasc Res"},{"key":"B136","doi-asserted-by":"publisher","first-page":"e12661","DOI":"10.1111\/jpi.12661","article-title":"Melatonin protects against thoracic aortic aneurysm and dissection through SIRT1-dependent regulation of oxidative stress and vascular smooth muscle cell loss","volume":"69","author":"Xia","year":"2020","journal-title":"J Pineal Res"},{"key":"B137","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.3390\/nu15071640","article-title":"Low zinc alleviates the progression of thoracic aortic dissection by inhibiting inflammation","volume":"15","author":"Zhu","year":"2023","journal-title":"Nutrients"},{"key":"B138","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.3390\/cells10092433","article-title":"Inflammasomes in the pathophysiology of aortic disease","volume":"10","author":"Wortmann","year":"2021","journal-title":"Cells-Basel"},{"key":"B139","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.cca.2018.08.005","article-title":"Cytokines in aortic dissection","volume":"486","author":"Zeng","year":"2018","journal-title":"Clin Chim Acta"},{"key":"B140","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3389\/fphys.2020.00054","article-title":"The role of macrophages in aortic dissection","volume":"11","author":"Wang","year":"2020","journal-title":"Front Physiol"},{"key":"B141","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1093\/eurheartj\/ehac823","article-title":"Targeting endothelial tight junctions to predict and protect thoracic aortic aneurysm and dissection","volume":"44","author":"Yang","year":"2023","journal-title":"Eur Heart J"},{"key":"B142","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.arr.2008.08.001","article-title":"Inflammatory response is associated with aortic dissection","volume":"8","author":"Luo","year":"2009","journal-title":"Ageing Res Rev"},{"key":"B143","doi-asserted-by":"publisher","first-page":"441","DOI":"10.3109\/07853890.2015.1073346","article-title":"Stanford-A acute aortic dissection, inflammation, and metalloproteinases: a review","volume":"47","author":"Cifani","year":"2015","journal-title":"Ann Med"},{"key":"B144","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.ebiom.2019.09.041","article-title":"Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1\u03b1-ADAM17 pathway(\u2730)","volume":"49","author":"Lian","year":"2019","journal-title":"Ebiomedicine"},{"key":"B145","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"B146","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1161\/CIRCRESAHA.116.304918","article-title":"Adventitial CXCL1\/G-CSF expression in response to acute aortic dissection triggers local neutrophil recruitment and activation leading to aortic rupture","volume":"116","author":"Anzai","year":"2015","journal-title":"Circ Res"},{"key":"B147","doi-asserted-by":"publisher","first-page":"110618","DOI":"10.1016\/j.intimp.2023.110618","article-title":"Relationship between inflammatory-related cytokines with aortic dissection","volume":"122","author":"Song","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"B148","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1182\/blood-2002-09-2785","article-title":"Oxidative stress is a critical mediator of the angiotensin II signal in human neutrophils: involvement of mitogen-activated protein kinase, calcineurin, and the transcription factor NF-kappaB","volume":"102","author":"El","year":"2003","journal-title":"Blood"},{"key":"B149","doi-asserted-by":"publisher","first-page":"e148668","DOI":"10.1172\/jci.insight.148668","article-title":"Angiotensin II triggers release of neutrophil extracellular traps, linking thromboinflammation with essential hypertension","volume":"6","author":"Chrysanthopoulou","year":"2021","journal-title":"JCI Insight"},{"key":"B150","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.freeradbiomed.2022.02.005","article-title":"Melatonin alleviates PM(2.5)-triggered macrophage M1 polarization and atherosclerosis via regulating NOX2-mediated oxidative stress homeostasis","volume":"181","author":"Liu","year":"2022","journal-title":"Free Radic Biol Med"},{"key":"B151","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/s41467-019-08680-6","article-title":"Macrophage achieves self-protection against oxidative stress-induced ageing through the mst-Nrf2 axis","volume":"10","author":"Wang","year":"2019","journal-title":"Nat Commun"},{"key":"B152","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.redox.2017.11.017","article-title":"Oxidized LDL triggers changes in oxidative stress and inflammatory biomarkers in human macrophages","volume":"15","author":"Lara-Guzm\u00e1n","year":"2018","journal-title":"Redox Biol"},{"key":"B153","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1161\/CIRCRESAHA.119.315833","article-title":"Mitochondrial metabolic reprogramming by CD36 signaling drives macrophage inflammatory responses","volume":"125","author":"Chen","year":"2019","journal-title":"Circ Res"},{"key":"B154","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1093\/eurheartj\/ehaa770","article-title":"Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1): a crucial driver of atherosclerotic cardiovascular disease","volume":"42","author":"Akhmedov","year":"2021","journal-title":"Eur Heart J"},{"key":"B155","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1161\/CIRCRESAHA.114.302153","article-title":"Macrophage mitochondrial oxidative stress promotes atherosclerosis and nuclear factor-\u03baB-mediated inflammation in macrophages","volume":"114","author":"Wang","year":"2014","journal-title":"Circ Res"},{"key":"B156","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1161\/01.RES.0000115557.25127.8D","article-title":"Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor","volume":"94","author":"Wassmann","year":"2004","journal-title":"Circ Res"},{"key":"B157","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.redox.2017.02.019","article-title":"CO-releasing molecules CORM2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS\/IL-6 generation and matrix metalloproteinases-9 expression","volume":"12","author":"Tsai","year":"2017","journal-title":"Redox Biol"},{"key":"B158","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1161\/hy0302.104670","article-title":"Oxidative stress in leukocytes is a possible link between blood pressure, blood glucose, and C-reacting protein","volume":"39","author":"Yasunari","year":"2002","journal-title":"Hypertension"},{"key":"B159","doi-asserted-by":"publisher","first-page":"114121","DOI":"10.1016\/j.bcp.2020.114121","article-title":"TNF-\u03b1 inhibition decreases MMP-2 activity, reactive oxygen species formation and improves hypertensive vascular hypertrophy independent of its effects on blood pressure","volume":"180","author":"Mattos","year":"2020","journal-title":"Biochem Pharmacol"},{"key":"B160","doi-asserted-by":"publisher","first-page":"1058488","DOI":"10.3389\/fphar.2023.1058488","article-title":"Regulation by Nrf2 of IL-1\u03b2-induced inflammatory and oxidative response in VSMC and its relationship with TLR4","volume":"14","author":"Gonz\u00e1lez-Carnicero","year":"2023","journal-title":"Front Pharmacol"},{"key":"B161","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.lfs.2018.12.043","article-title":"Sestrin2 increases in aortas and plasma from aortic dissection patients and alleviates angiotensin II-induced smooth muscle cell apoptosis via the Nrf2 pathway","volume":"218","author":"Xiao","year":"2019","journal-title":"Life sci"},{"key":"B162","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1093\/cvr\/cvab010","article-title":"NLRP3 inflammasome as a key driver of vascular disease","volume":"118","author":"Takahashi","year":"2022","journal-title":"Cardiovasc Res"},{"key":"B163","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1089\/ars.2020.8257","article-title":"Loop between NLRP3 inflammasome and reactive oxygen Species","volume":"36","author":"Dominic","year":"2022","journal-title":"Antioxid Redox Signal"},{"key":"B164","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1161\/ATVBAHA.114.303763","article-title":"Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm","volume":"35","author":"Usui","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B165","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.yjmcc.2015.02.005","article-title":"Macrophage inflammasome mediates hyperhomocysteinemia-aggravated abdominal aortic aneurysm","volume":"81","author":"Sun","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"B166","doi-asserted-by":"publisher","first-page":"175361","DOI":"10.1016\/j.ejphar.2022.175361","article-title":"Oltipraz, the activator of nuclear factor erythroid 2-related factor 2 (Nrf2), protects against the formation of BAPN-induced aneurysms and dissection of the thoracic aorta in mice by inhibiting activation of the ROS-mediated NLRP3 inflammasome","volume":"936","author":"Wang","year":"2022","journal-title":"Eur J Pharmacol"},{"key":"B167","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/nrm.2017.36","article-title":"Vascular heterogeneity and specialization in development and disease","volume":"18","author":"Potente","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B168","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1093\/eurheartj\/ehac771","article-title":"The emerging role of endothelial cells in the pathogenesis of thoracic aortic aneurysm and dissection","volume":"44","author":"Verstraeten","year":"2023","journal-title":"Eur Heart J"},{"key":"B169","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1161\/hc2901.091399","article-title":"Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E\/endothelial nitric oxide synthase double-knockout mice","volume":"104","author":"Kuhlencordt","year":"2001","journal-title":"Circulation"},{"key":"B170","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s11658-023-00423-2","article-title":"Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets","volume":"28","author":"Janaszak-Jasiecka","year":"2023","journal-title":"Cell Mol Biol Lett"},{"key":"B171","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: regulation and function","volume":"33","author":"F\u00f6rstermann","year":"2012","journal-title":"Eur Heart J"},{"key":"B172","doi-asserted-by":"publisher","first-page":"9056","DOI":"10.1073\/pnas.0409594102","article-title":"Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase","volume":"102","author":"Chalupsky","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B173","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1161\/HYPERTENSIONAHA.111.181644","article-title":"Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: treatment with folic acid","volume":"59","author":"Gao","year":"2012","journal-title":"Hypertension"},{"key":"B174","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.redox.2016.11.002","article-title":"NOX isoforms in the development of abdominal aortic aneurysm","volume":"11","author":"Siu","year":"2017","journal-title":"Redox Biol"},{"key":"B175","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/S0008-6363(99)00171-6","article-title":"Nitric oxide and the proliferation of vascular smooth muscle cells","volume":"43","author":"Jeremy","year":"1999","journal-title":"Cardiovasc Res"},{"key":"B176","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1016\/j.bbrc.2017.07.033","article-title":"Laminar shear stress suppresses vascular smooth muscle cell proliferation through nitric oxide-AMPK pathway","volume":"490","author":"Kim","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"B177","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1161\/01.CIR.0000144462.08345.B9","article-title":"Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction","volume":"110","author":"Amiri","year":"2004","journal-title":"Circulation"},{"key":"B178","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.freeradbiomed.2004.04.018","article-title":"Reactive oxygen species mediate endothelin-1-induced activation of ERK1\/2, PKB, and Pyk2 signaling, as well as protein synthesis, in vascular smooth muscle cells","volume":"37","author":"Daou","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"B179","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1161\/01.ATV.20.4.989","article-title":"Endothelin-1 inhibits apoptosis of vascular smooth muscle cells induced by nitric oxide and serum deprivation via MAP kinase pathway","volume":"20","author":"Shichiri","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B180","doi-asserted-by":"publisher","first-page":"166278","DOI":"10.1016\/j.bbadis.2021.166278","article-title":"Endothelial cell-derived pro-fibrotic factors increase TGF-\u03b21 expression by smooth muscle cells in response to cycles of hypoxia-hyperoxia","volume":"1868","author":"Ismaeel","year":"2022","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B181","doi-asserted-by":"publisher","first-page":"a022210","DOI":"10.1101\/cshperspect.a022210","article-title":"TGF-\u03b2 signaling in control of cardiovascular function","volume":"10","author":"Goumans","year":"2018","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B182","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.3390\/ijms19072125","article-title":"TGF-\u03b2 signaling-related genes and thoracic aortic aneurysms and dissections","volume":"19","author":"Takeda","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B183","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1093\/cvr\/cvs298","article-title":"Importance of endothelial NF-\u03baB signalling in vascular remodelling and aortic aneurysm formation","volume":"97","author":"Saito","year":"2013","journal-title":"Cardiovasc Res"},{"key":"B184","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1038\/s41419-020-02985-x","article-title":"NLRP3 inflammasome in endothelial dysfunction","volume":"11","author":"Bai","year":"2020","journal-title":"Cell Death Dis"},{"key":"B185","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.3390\/biomedicines10102597","article-title":"Synthetic mono-carbonyl curcumin analogues attenuate oxidative stress in mouse models","volume":"10","author":"Hussain","year":"2022","journal-title":"Biomedicines"},{"key":"B186","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1080\/10408398.2016.1229657","article-title":"Natural antioxidant polyphenols on inflammation management: anti-glycation activity vs metalloproteinases inhibition","volume":"58","author":"Crasc\u00ec","year":"2018","journal-title":"Crit Rev Food Sci Nutr"},{"key":"B187","doi-asserted-by":"publisher","first-page":"523","DOI":"10.3390\/nu9050523","article-title":"Effects of polyphenols on oxidative stress-mediated injury in cardiomyocytes","volume":"9","author":"Mattera","year":"2017","journal-title":"Nutrients"},{"key":"B188","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s00059-016-4489-2","article-title":"Role of nifedipine and hydrochlorothiazide in MAPK activation and vascular smooth muscle cell proliferation and apoptosis","volume":"42","author":"Wang","year":"2017","journal-title":"Herz"},{"key":"B189","doi-asserted-by":"publisher","first-page":"9247285","DOI":"10.1155\/2021\/9247285","article-title":"Sphingosine kinase 1 plays an important role in atorvastatin-mediated anti-inflammatory effect against acute lung injury","volume":"2021","author":"Wu","year":"2021","journal-title":"Mediators Inflamm"},{"key":"B190","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.bbrc.2013.01.049","article-title":"Lancemaside A inhibits microglial activation via modulation of JNK signaling pathway","volume":"431","author":"Jeong","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"B191","doi-asserted-by":"publisher","first-page":"166819","DOI":"10.1016\/j.bbadis.2023.166819","article-title":"Senkyunolide I ameliorates thoracic aortic aneurysm and dissection in mice via inhibiting the oxidative stress and apoptosis of endothelial cells","volume":"1869","author":"Zhao","year":"2023","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B192","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.1161\/CIRCULATIONAHA.116.026099","article-title":"Nicotinamide riboside preserves cardiac function in a mouse model of dilated cardiomyopathy","volume":"137","author":"Diguet","year":"2018","journal-title":"Circulation"},{"key":"B193","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1161\/01.CIR.0000143630.14515.7C","article-title":"N-acetylcysteine treatment normalizes serum tumor necrosis factor-alpha level and hinders the progression of cardiac injury in hypertensive rats","volume":"110","author":"Bourraindeloup","year":"2004","journal-title":"Circulation"},{"key":"B194","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1161\/CIRCRESAHA.120.317046","article-title":"NAD(+) repletion reverses heart failure with preserved ejection fraction","volume":"128","author":"Tong","year":"2021","journal-title":"Circ Res"},{"key":"B195","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.1161\/CIRCULATIONAHA.117.032626","article-title":"Raising NAD in heart failure: time to translate?","volume":"137","author":"Walker","year":"2018","journal-title":"Circulation"},{"key":"B196","doi-asserted-by":"publisher","first-page":"eabd7064","DOI":"10.1126\/scitranslmed.abd7064","article-title":"Nicotinamide for the treatment of heart failure with preserved ejection fraction","volume":"13","author":"Abdellatif","year":"2021","journal-title":"Sci Transl Med"},{"key":"B197","doi-asserted-by":"publisher","first-page":"6054","DOI":"10.1172\/JCI138538","article-title":"Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure","volume":"130","author":"Zhou","year":"2020","journal-title":"J Clin Invest"},{"key":"B198","doi-asserted-by":"publisher","first-page":"246","DOI":"10.3389\/fcell.2020.00246","article-title":"Nicotinamide mononucleotide: a promising molecule for therapy of diverse diseases by targeting NAD+ metabolism","volume":"8","author":"Hong","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B199","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1161\/01.RES.0000049166.33035.62","article-title":"Long-term vitamin C treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity","volume":"92","author":"D'Uscio","year":"2003","journal-title":"Circ Res"},{"key":"B200","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1161\/01.HYP.0000057421.28533.37","article-title":"Vitamins reverse endothelial dysfunction through regulation of eNOS and NAD(P)H oxidase activities","volume":"41","author":"Ulker","year":"2003","journal-title":"Hypertension"},{"key":"B201","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.lfs.2015.09.006","article-title":"Vitamin C prevents the endothelial dysfunction induced by acute ethanol intake","volume":"141","author":"Hip\u00f3lito","year":"2015","journal-title":"Life Sci"},{"key":"B202","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1161\/ATVBAHA.116.307841","article-title":"Resveratrol inhibits aortic root dilatation in the Fbn1C1039G\/+ Marfan mouse model","volume":"36","author":"Hibender","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B203","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1161\/hc4501.098928","article-title":"Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy","volume":"104","author":"Cappola","year":"2001","journal-title":"Circulation"},{"key":"B204","doi-asserted-by":"publisher","first-page":"265","DOI":"10.2147\/VHRM.S4265","article-title":"Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress","volume":"5","author":"George","year":"2009","journal-title":"Vasc Health Risk Manag"},{"key":"B205","doi-asserted-by":"publisher","first-page":"D8176","DOI":"10.1002\/14651858.CD008176.pub3","article-title":"Antioxidants for adults with chronic kidney disease","volume":"11","author":"Colombijn","year":"2023","journal-title":"Cochrane Database Syst Rev"},{"key":"B206","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1017\/S0029665108007052","article-title":"Antioxidants and CVD","volume":"67","author":"Bruckdorfer","year":"2008","journal-title":"Proc Nutr Soc"},{"key":"B207","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/diseases4010011","article-title":"Antioxidants and cardiovascular risk factors","volume":"4","author":"Pellegrino","year":"2016","journal-title":"Diseases"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1410477\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:57:08Z","timestamp":1720745828000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1410477\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,12]]},"references-count":207,"alternative-id":["10.3389\/fcvm.2024.1410477"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2024.1410477","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,12]]},"article-number":"1410477"}}