{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T23:54:18Z","timestamp":1781049258608,"version":"3.54.1"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Takotsubo syndrome (TTS) is a rare disease mimicking acute coronary syndrome, often triggered by physical or emotional stress, and characterized by transient left ventricular dysfunction. Recurrences are described in about 5% of cases and may have different clinical and imaging patterns. In the present report, SARS-COV-2 infection, even in the absence of symptoms and overt emotional stress, seems correlated with recurrence of TTS, due to the absence of other recognized triggers. The hypothesis is that in predisposed patients, events like catecholamine-induced myocyte injury, direct viral damage, cytokine storm, immune-mediated damage, and procoagulant state, all possibly induced by the infection, may elicit endothelial dysfunction as substrate for TTS onset.<\/jats:p>","DOI":"10.3389\/fcvm.2024.1418316","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T04:52:55Z","timestamp":1716526375000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Asymptomatic SARS-COV2 infection triggering recurrent Takotsubo syndrome"],"prefix":"10.3389","volume":"11","author":[{"given":"Gianni","family":"Dall\u2019Ara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Compagnone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Carletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Piciucchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Gardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Galvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1001\/jamacardio.2020.1105","article-title":"Association of coronavirus disease 2019 (COVID-19) with myocardial injury and mortality","volume":"5","author":"Bonow","year":"2020","journal-title":"JAMA Cardiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1093\/eurheartj\/ehy076","article-title":"International expert consensus document on Takotsubo syndrome (part I): clinical characteristics, diagnostic criteria, and pathophysiology","volume":"39","author":"Ghadri","year":"2018","journal-title":"Eur Heart J"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.4081\/monaldi.2021.1710","article-title":"A review of the presentation and outcome of Takotsubo cardiomyopathy in COVID-19","volume":"91","author":"John","year":"2021","journal-title":"Monaldi Arch Chest Dis"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e180822207660","DOI":"10.2174\/1573403X18666220818155039","article-title":"Takotsubo cardiomyopathy and COVID-19: a case report and literature review","volume":"19","author":"Jos\u00e9","year":"2023","journal-title":"Curr Cardiol Rev"},{"key":"B5","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.ijcard.2014.04.221","article-title":"Systematic review and meta-analysis of incidence and correlates of recurrence of Takotsubo cardiomyopathy","volume":"174","author":"Singh","year":"2014","journal-title":"Int J Cardiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1136\/heartjnl-2020-318028","article-title":"Survival and risk of recurrence of Takotsubo syndrome","volume":"107","author":"Lau","year":"2021","journal-title":"Heart"},{"key":"B7","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.jacc.2018.12.033","article-title":"Takotsubo recurrence: morphological types and triggers and identification of risk factors","volume":"73","author":"Kato","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e2014780","DOI":"10.1001\/jamanetworkopen.2020.14780","article-title":"Incidence of stress cardiomyopathy during the coronavirus disease 2019 pandemic","volume":"3","author":"Jabri","year":"2020","journal-title":"JAMA Netw Open"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yjmcc.2024.04.009","article-title":"An update on the mechanisms of Takotsubo syndrome: \u201cat the end an acute coronary syndrome.\u201d","volume":"191","author":"Crea","year":"2024","journal-title":"J Mol Cell Cardiol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1093\/eurheartj\/ehad274","article-title":"Takotsubo syndrome is a coronary microvascular disease: experimental evidence","volume":"44","author":"Dong","year":"2023","journal-title":"Eur Heart J"},{"key":"B11","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.ijcard.2021.02.033","article-title":"Transient Takotsubo syndrome and its recurrence: why does it happen, why does it end, and why does it rarely reappear?","volume":"330","author":"Angelini","year":"2021","journal-title":"Int J Cardiol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"309","DOI":"10.2217\/fca-2020-0043","article-title":"Recurrent asymptomatic takotsubo syndrome after 20 years: are we looking at the tip of the iceberg only?","volume":"17","author":"Iannaccone","year":"2021","journal-title":"Future Cardiol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e52","DOI":"10.1016\/j.ijcard.2014.04.033","article-title":"Tako-tsubo cardiomyopathy triggered by influenza A virus infection","volume":"174","author":"Lozano","year":"2014","journal-title":"Int J Cardiol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.jacc.2020.05.068","article-title":"Takotsubo cardiomyopathy in COVID-19","volume":"76","author":"Giustino","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1056\/NEJMoa1406761","article-title":"Clinical features and outcomes of Takotsubo (stress) cardiomyopathy","volume":"373","author":"Templin","year":"2015","journal-title":"N Engl J Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1136\/heartjnl-2023-322980","article-title":"Beta-blockers and renin-angiotensin system inhibitors for Takotsubo syndrome recurrence: a network meta-analysis","volume":"110","author":"Santoro","year":"2024","journal-title":"Heart"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1093\/eurheartj\/ehaa286","article-title":"Acute myocarditis presenting as a reverse Tako-tsubo syndrome in a patient with SARS-CoV-2 respiratory infection","volume":"41","author":"Sala","year":"2020","journal-title":"Eur Heart J"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1418316\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T04:52:59Z","timestamp":1716526379000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1418316\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,24]]},"references-count":17,"alternative-id":["10.3389\/fcvm.2024.1418316"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2024.1418316","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,24]]},"article-number":"1418316"}}