{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:57:14Z","timestamp":1792979834792,"version":"4.5.0"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Objects<\/jats:title><jats:p>The aim of this study was to investigate the morphologic changes of a novel fully biodegradable implantable device after closing a perimembranous ventricular septal defect (Pm-VSD) and to evaluate the effect of the occluder on the myocardial function in patients during a 3-year follow-up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One-year, 2-year, and 3-year follow-ups were carried out after implantation with a total of 30 Pm-VSD patients who had successful closure by the fully biodegradable occluder. In total, 30 healthy children were enrolled as controls. At discharge and at every follow-up visit, the lengths of the left and right discs of the novel device were measured in the apical three- and four-chamber as well as short-axis views. At the end of the follow-up, using three-dimensional speckle-tracking conditions, the values of myocardial deformation, including global longitudinal strain, global circumferential strain, and global area strain, were acquired.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The fully bioabsorbable double-disc occluder gradually decreased over time and was eventually invisible under echocardiographic scanning during the follow-up (<jats:italic>p\u2009<\/jats:italic>&amp;lt;\u20090.05). At the end of the third year, there were no significant differences in the myocardial deformation parameters between the cases implanted with the novel devices and the controls; no significant differences were found between the basal segments of the ventricle septa and that of the left ventricle (LV) free wall among the patients who completed the Pm-VSD closure using the fully biodegradable occluder (<jats:italic>p\u2009<\/jats:italic>&amp;gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The novel fully biodegradable occluder is a safe, effective, and perfect alternative for the treatment of VSD. Echocardiography plays a crucial role in the follow-up of this new type of occluder implantation.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2024.1420704","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T13:41:48Z","timestamp":1719927708000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["The 3-year follow-up of a fully biodegradable implantable device closure for perimembranous ventricular septal defects in children using echocardiography"],"prefix":"10.3389","volume":"11","author":[{"given":"Juan","family":"Cong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunying","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sifan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubo","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taibing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1016\/S0140-6736(10)61339-6","article-title":"Ventricular septal defect","volume":"377","author":"Penny","year":"2011","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1080\/17434440.2016.1182860","article-title":"Historical developments of atrial septal defect closure devices: what we learn from the past","volume":"13","author":"Nassif","year":"2016","journal-title":"Expert Rev Med Devices"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1056\/NEJMoa1610057","article-title":"Long-term outcomes of patent foramen ovale closure or medical therapy after stroke","volume":"377","author":"Saver","year":"2017","journal-title":"N Engl J Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"8948249","DOI":"10.1155\/2020\/8948249","article-title":"Transcatheter closure of perimembranous ventricular septal defects using different generations of amplatzer devices: multicenter experience","volume":"2020","author":"Mijangos-V\u00e1zquez","year":"2020","journal-title":"J Interv Cardiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s12928-020-00677-z","article-title":"Effect of transcatheter closure by Amplatzer(TM) Duct Occluder II in patients with small ventricular septal defect","volume":"36","author":"Wongwaitaweewong","year":"2021","journal-title":"Cardiovasc Interv Ther"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1255808","DOI":"10.3389\/fcvm.2023.1255808","article-title":"Safety and efficacy of Amplatzer duct occluder II and konar-M VSD occluder in the closure of perimembranous ventricular septal defects in children weighing less than 10 kg","volume":"10","author":"Yildiz","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s13019-019-0900-4","article-title":"Changes in the levels of inflammatory markers after transthoracic device closure of ventricular septal defects in pediatric patients","volume":"14","author":"Huang","year":"2019","journal-title":"J Cardiothorac Surg"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1016\/j.jacc.2014.01.008","article-title":"Transcatheter versus surgical closure of perimembranous ventricular septal defects in children: a randomized controlled trial","volume":"63","author":"Yang","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.bioactmat.2022.12.018","article-title":"A fully biodegradable polydioxanone occluder for ventricle septal defect closure","volume":"24","author":"Li","year":"2023","journal-title":"Bioact Mater"},{"key":"B10","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.xjtc.2022.11.010","article-title":"Favorable mid-term performance of fully biodegradable implantable device for ventricular septal defect closure","volume":"17","author":"Song","year":"2023","journal-title":"JTCVS Tech"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1016\/j.jcin.2019.09.057","article-title":"First-in-human experience with a novel fully bioabsorbable occluder for ventricular septal defect","volume":"13","author":"Chen","year":"2020","journal-title":"JACC Cardiovasc Interv"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7120-13-6","article-title":"Structural and functional changes in maternal left ventricle during pregnancy: a three-dimensional speckle-tracking echocardiography study","volume":"13","author":"Cong","year":"2015","journal-title":"Cardiovasc Ultrasound"},{"key":"B14","first-page":"380","article-title":"Development of biodegradable occluders in device closure treatment for congenital heart defects","volume":"33","author":"Xing Quansheng","year":"2017","journal-title":"Chin J Thorue Cardliovasc Surg"},{"key":"B15","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.actbio.2019.05.073","article-title":"Biodegradable atrial septal defect occluders: a current review","volume":"96","author":"Shi","year":"2019","journal-title":"Acta Biomater"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1420704\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T13:41:51Z","timestamp":1719927711000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1420704\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,2]]},"references-count":15,"alternative-id":["10.3389\/fcvm.2024.1420704"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2024.1420704","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,2]]},"article-number":"1420704"}}