{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:50:16Z","timestamp":1753890616364,"version":"3.41.2"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>A case of a 44-year-old man presenting with a family history of LMNA mutation and cardiac symptoms (dizziness, weakness, palpitations, and shortness of breath) congruent with dilated cardiomyopathy. Genetic testing revealed a novel likely pathogenic mutation of the LMNA gene (c.513G&amp;gt;A, exon 2) not previously associated with dilated cardiomyopathy, and the patient underwent guideline direct treatment for dilated cardiomyopathy. In patients with LMNA mutations, VTA risk should be calculated to determine the need for prophylactic ICD placement.<\/jats:p>","DOI":"10.3389\/fcvm.2024.1422151","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T04:30:23Z","timestamp":1727757023000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dilated cardiomyopathy due to novel LMNA mutation: a case report"],"prefix":"10.3389","volume":"11","author":[{"given":"Riddhi","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raj","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekta","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehul","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1111\/joim.12944","article-title":"Dilated cardiomyopathy: from epidemiologic to genetic phenotypes","volume":"286","author":"Reichart","year":"2019","journal-title":"J Intern Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1006\/jmcc.2001.1340","article-title":"The molecular genetic basis for hypertrophic cardiomyopathy","volume":"33","author":"Marian","year":"2001","journal-title":"J Mol Cell Cardiol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"ytac128","DOI":"10.1093\/ehjcr\/ytac128","article-title":"A case report of a novel mutation in lamin A\/C gene related with risk of sudden death","volume":"6","author":"Sanchez Vallejo","year":"2022","journal-title":"Eur Heart J Case Rep"},{"key":"B4","doi-asserted-by":"publisher","first-page":"761","DOI":"10.3389\/fphys.2020.00761","article-title":"The broad spectrum of LMNA cardiac diseases: from molecular mechanisms to clinical phenotype","volume":"11","author":"Crasto","year":"2020","journal-title":"Front Physiol"},{"key":"B5","first-page":"309","article-title":"Dilated cardiomyopathy produced by lamin A\/C gene mutations","volume":"86","author":"Goidescu","year":"2013","journal-title":"Clujul Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1161\/CIRCULATIONAHA.118.039410","article-title":"Development and validation of a new risk prediction score for life-threatening ventricular tachyarrhythmias in laminopathies","volume":"140","author":"Wahbi","year":"2019","journal-title":"Circulation"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e895","DOI":"10.1161\/CIR.000000000000106310.1161\/CIR.000000000000107310.1161\/CIR.000000000000109710.1161\/CIR.0000000000001142","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"key":"B8","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/nrcardio.2010.3","article-title":"Sudden cardiac death: epidemiology and risk factors","volume":"7","author":"Adabag","year":"2010","journal-title":"Nat Rev Cardiol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.jacbts.2022.03.008","article-title":"Maintaining success for patients with dilated cardiomyopathy and remission of heart failure","volume":"7","author":"Halliday","year":"2022","journal-title":"JACC Basic Transl Sci"},{"key":"B10","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1093\/ehjci\/jeab057","article-title":"Progression of cardiac disease in patients with lamin A\/C mutations","volume":"23","author":"Skj\u00f8lsvik","year":"2022","journal-title":"Eur Heart J Cardiovasc Imaging"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1422151\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T04:30:24Z","timestamp":1727757024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1422151\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":10,"alternative-id":["10.3389\/fcvm.2024.1422151"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2024.1422151","relation":{},"ISSN":["2297-055X"],"issn-type":[{"type":"electronic","value":"2297-055X"}],"subject":[],"published":{"date-parts":[[2024,10,1]]},"article-number":"1422151"}}