{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:50:07Z","timestamp":1753890607855,"version":"3.41.2"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2020YFC2008100"],"award-info":[{"award-number":["2020YFC2008100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Rheumatic mitral stenosis (RMS) is a common valvular heart disease in developing countries. We sought to evaluate the early experience of patients with RMS undergoing transcatheter mitral valve replacement (TMVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, a total of 5 RMS patients accepted TMVR. All patients underwent computed tomography and echocardiography before having the procedure. After the preprocedural comprehensive evaluations, the surgeons planned to use the Prizvalve (a novel balloon-expandable transcatheter aortic valve system which is now under the clinical registration study) for TMVR. Clinical data were collected at baseline, before discharge, and at the 30-day follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age of the 5 RMS patients was 61 years (range 60\u201377 years); 60% were male, and the median Society of Thoracic Surgeons score was 13.3% (range 6.2\u201317.1%). TMVR was successful in all patients. Postoperative transesophageal echocardiography showed that 60.0% (<jats:italic>n<\/jats:italic>\u2009=\u20093) of the patients had no paravalvular leakage and 40.0% (<jats:italic>n<\/jats:italic>\u2009=\u20092) had trace paravalvular leakage. The median postoperative peak velocity decreased to 1.4\u2005m\/s (range 1.1\u20131.7\u2005m\/s), and the median pressure gradient decreased to 3 mmHg (range 2\u20133\u2005mmHg). No deaths occurred at the 30-day follow-up, and all patients had an improvement of \u22651 on the New York Heart Association functional rating.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our early experience with TMVR in RMS patients suggests that it is a safe and feasible procedure. The early results of the procedure are acceptable and provide bright prospects and directions for the precision treatment of RMS.\n<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p><jats:uri>ClinicalTrials.gov<\/jats:uri>, identifier (NCT02917980).<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2024.1424105","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T06:29:59Z","timestamp":1733380199000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcatheter mitral valve replacement to treat rheumatic mitral stenosis: a case 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