{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:00:30Z","timestamp":1791910830437,"version":"4.3.4"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study examines the relationship between Hb, RDW and their association and both short-term and long-term mortality in patients with acute aortic dissection (AAD), aiming to establish combined effect between Hb and RDW as a potential prognostic biomarker for AAD outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We extracted clinical data from the Medical Information Mart for Intensive Care (MIMIC) databases for this analysis. Using adjusted Cox regression and Kaplan-Meier survival curve analyses, we assessed the relationship between Hb, RDW and their association at admission and mortality at multiple post-discharge intervals (30 days, 90 days, 1 year, and 5 years) among patients with AAD. Additionally, subgroup analyses and receiver operating characteristic (ROC) curve analyses were conducted to evaluate the predictive accuracy of Hb, RDW and their association for mortality in this patient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High RDW combined with low Hb (RDW\u2009\u2265\u200913.60 and Hb\u2009&amp;lt;\u20097.9) significantly predicted increased mortality at 30 days, 90 days, 1 year, and 5 years post-diagnosis, with hazard ratios (HRs) as follows: 4.33 (95% CI: 1.82\u201310.33, <jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.001), 4.48 (95% CI: 2.06\u20139.77, <jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.001), 3.38 (95% CI: 1.70\u20136.70, <jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.001), and 3.07 (95% CI: 1.66\u20135.66, <jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.001), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hb and RDW are both abnormal (Hb with low level, RDW with high level) is positively correlated with 30 days, 90 days, 1 year, and 5 years mortality risk in patients with AAD. This suggests that combined effect between Hb and RDW is a significant predictor of short-term to long-term mortality risk in this patient population, highlighting its potential utility as a prognostic marker in clinical settings.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2024.1444498","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T07:01:23Z","timestamp":1736146883000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The correlation and predictive value of Hb, RDW and their association for short-term and long-term mortality in patients with acute aortic dissection"],"prefix":"10.3389","volume":"11","author":[{"given":"Peng","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangran","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huishan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/S0140-6736(22)01970-5","article-title":"Acute aortic dissection","volume":"401","author":"Carrel","year":"2023","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.jtcvs.2021.04.053","article-title":"2021 The American association for thoracic surgery expert consensus document: surgical treatment of acute type A aortic dissection","volume":"162","author":"Malaisrie","year":"2021","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B3","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1093\/eurheartj\/ehac757","article-title":"Acute aortic dissection: evidence, uncertainties, and future therapies","volume":"44","author":"Rylski","year":"2023","journal-title":"Eur Heart J"},{"key":"B4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/nyas.14092","article-title":"Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries","volume":"1450","author":"Chaparro","year":"2019","journal-title":"Ann N Y Acad Sci"},{"key":"B5","first-page":"104","article-title":"Anaemia: a disease or symptom","volume":"78","author":"Newhall","year":"2020","journal-title":"Neth J Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1016\/j.athoracsur.2018.06.055","article-title":"Impact of frailty on outcomes in acute type A aortic dissection","volume":"106","author":"Gomibuchi","year":"2018","journal-title":"Ann Thorac Surg"},{"key":"B7","doi-asserted-by":"publisher","first-page":"588761","DOI":"10.3389\/fcvm.2020.588761","article-title":"Prognostic value of preoperative hemoglobin levels for long-term outcomes of acute type B aortic dissection post-thoracic endovascular aortic repair","volume":"7","author":"Gao","year":"2020","journal-title":"Front Cardiovasc Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.jvs.2022.08.037","article-title":"Anemia is associated with higher mortality and morbidity after thoracic endovascular aortic repair","volume":"77","author":"Yin","year":"2023","journal-title":"J Vasc Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/0736-4679(91)90592-4","article-title":"The red blood cell distribution width","volume":"9","author":"Evans","year":"1991","journal-title":"J Emerg Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"413","DOI":"10.2147\/JBM.S367660","article-title":"Red blood cell distribution width as novel biomarker in cardiovascular diseases: a literature review","volume":"13","author":"Arkew","year":"2022","journal-title":"J Blood Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"102476","DOI":"10.1016\/j.cpcardiol.2024.102476","article-title":"Systematic literature review and critical analysis of RDW in patients with aortic pathologies","volume":"49","author":"Lippi","year":"2024","journal-title":"Curr Probl Cardiol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"788476","DOI":"10.3389\/fcvm.2022.788476","article-title":"Red blood cell distribution width: a prognostic marker in patients with type B aortic dissection undergoing endovascular aortic repair","volume":"9","author":"Jiang","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"131368","DOI":"10.1016\/j.ijcard.2023.131368","article-title":"Hemoglobin to red cell distribution width ratio: a predictor of clinical outcome and diuretic response in patients with acute heart failure","volume":"394","author":"Chen","year":"2024","journal-title":"Int J Cardiol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"726025","DOI":"10.3389\/fcvm.2022.726025","article-title":"Hemoglobin-to-red-cell distribution width ratio is a novel predictor of long-term patient outcomes after percutaneous coronary intervention: a retrospective cohort study","volume":"9","author":"Xiu","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"728800","DOI":"10.3389\/fcvm.2021.728800","article-title":"Correlation analysis of hemoglobin-to-red blood cell distribution width ratio and frailty in elderly patients with coronary heart disease","volume":"8","author":"Qu","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1259668","DOI":"10.3389\/fnagi.2023.1259668","article-title":"Hemoglobin to red cell distribution width ratio as a prognostic marker for ischemic stroke after mechanical thrombectomy","volume":"15","author":"Feng","year":"2023","journal-title":"Front Aging Neurosci"},{"key":"B17","doi-asserted-by":"publisher","first-page":"473","DOI":"10.2217\/bmm-2021-0577","article-title":"Prognostic value of hemoglobin-to-red cell distribution width ratio in cancer: a systematic review and meta-analysis","volume":"16","author":"Chi","year":"2022","journal-title":"Biomark Med"},{"key":"B18","doi-asserted-by":"publisher","first-page":"160035","DOI":"10.1038\/sdata.2016.35","article-title":"MIMIC-III, a freely accessible critical care database","volume":"3","author":"Johnson","year":"2016","journal-title":"Sci Data"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41597-022-01899-x","article-title":"MIMIC-IV, a freely accessible electronic health record dataset","volume":"10","author":"Johnson","year":"2023","journal-title":"Sci Data"},{"key":"B20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-3-319-43742-2","volume-title":"The Story of MIMIC. Secondary Analysis of Electronic Health Records","author":"Data","year":"2016"},{"key":"B21","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1161\/CIRCULATIONAHA.110.015081","article-title":"Total arch replacement combined with stented elephant trunk implantation: a new \u201cstandard\u201d therapy for type a dissection involving repair of the aortic arch?","volume":"123","author":"Sun","year":"2011","journal-title":"Circulation"},{"key":"B22","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1093\/ejcts\/ezs043","article-title":"EuroSCORE II","volume":"41","author":"Nashef","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"key":"B23","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"Knaus","year":"1985","journal-title":"Crit Care Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1016\/j.athoracsur.2015.10.038","article-title":"Creation of a scorecard to predict in-hospital death in patients undergoing operations for acute type A aortic dissection","volume":"101","author":"Leontyev","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"B25","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1001\/jama.283.7.897","article-title":"The international registry of acute aortic dissection (IRAD): new insights into an old disease","volume":"283","author":"Hagan","year":"2000","journal-title":"Jama"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1444498\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T07:01:26Z","timestamp":1736146886000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1444498\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,6]]},"references-count":25,"alternative-id":["10.3389\/fcvm.2024.1444498"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2024.1444498","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,6]]},"article-number":"1444498"}}