{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:48:49Z","timestamp":1753890529782,"version":"3.41.2"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300803"],"award-info":[{"award-number":["82300803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies have established a correlation between systemic lupus erythematosus (SLE) and cardiovascular health, but the potential causal effects of SLE on heart function and structure remain poorly understood. Cardiovascular magnetic resonance imaging (CMR), a novel non-invasive technique, provides a unique assessment of cardiovascular structure and function, making it an essential tool for evaluating the risk of heart disease. In this study, we performed a Mendelian randomization analysis to determine the causal relationship between SLE and CMR traits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Genetic variants independently linked to SLE were selected from a genome-wide association study (GWAS) containing 5,201 cases and 9,066 controls as instrumental variables. A set of 82 CMR traits was obtained from a recent GWAS, serving as preclinical indicators and providing preliminary insights into the morphology and function of the four cardiac chambers and two aortic segments. Primary analysis employed a two-sample Mendelian randomization study using the inverse-variance weighted method. Heterogeneity testing, sensitivity analyses, and instrumental variable strength assessments confirmed the robustness of the findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SLE exhibited a correlation with increased stroke volume (\u03b2<jats:sub>LVSV<\/jats:sub>\u2009=\u20090.007, <jats:italic>P<\/jats:italic>\u2009=\u20090.045), regional peak circumferential strain (\u03b2<jats:sub>Ecc_AHA_9<\/jats:sub>\u2009=\u20090.013, <jats:italic>P<\/jats:italic>\u2009=\u20090.002; \u03b2<jats:sub>Ecc_AHA_12<\/jats:sub>\u2009=\u20090.009, <jats:italic>P<\/jats:italic>\u2009=\u20090.043; \u03b2<jats:sub>Ecc_AHA_14<\/jats:sub>\u2009=\u20090.013, <jats:italic>P<\/jats:italic>\u2009=\u20090.006), and global peak circumferential strain of the LV (\u03b2<jats:sub>Ecc_global<\/jats:sub>\u2009=\u20090.010, <jats:italic>P<\/jats:italic>\u2009=\u20090.022), as well as decreased regional radial strain (\u03b2<jats:sub>Err_AHA_11<\/jats:sub>\u2009=\u2009\u22120.010, <jats:italic>P<\/jats:italic>\u2009=\u20090.017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This research presents evidence of a potential causal association between traits of SLE and alterations in cardiac function, guiding cardiac examinations and disease prevention in lupus patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2024.1454645","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T04:29:09Z","timestamp":1727929749000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of systemic lupus erythematosus on cardiovascular morphologic and functional phenotypes: a Mendelian randomization 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