{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:49:53Z","timestamp":1783619393195,"version":"3.55.0"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In hypoplastic left heart syndrome (HLHS) patients, neo-aortic valve regurgitation can negatively impact right ventricular (RV) function. We assessed neo-aortic valve function and RV volumetric parameters by analysing serial cardiovascular magnetic resonance (CMR) studies in HLHS patients after completion of total cavopulmonary connection (TCPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive CMR examinations of 80 patients (female: 22) with two (<jats:italic>n<\/jats:italic>\u2009=\u200980) or three (<jats:italic>n<\/jats:italic>\u2009=\u200945) examinations each were retrospectively analysed. RV volumetry was performed using short-axis cine images. RV end-diastolic and end-systolic volumes normalised to body surface area (BSA, RVEDVi, RVESVi), ejection fraction (RVEF) and stroke volume (RVSV) were measured. Neo-aortic flow, regurgitant fraction (RF) and peak velocity were quantified from phase-contrast cine images.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median neo-aortic regurgitation was mild at all three examinations (RF &amp;lt;20%) and there was no significant increase in RF over time (<jats:italic>p<\/jats:italic>\u2009&amp;gt;\u20090.05). None of the patients had significant neo-aortic valve stenosis (peak velocity &amp;gt;3\u2005m\/s). RF correlated with RVESVi and RVEF at the second examination. At the third examination, RF correlated with RVESVi and RVEDVi even in patients with RF &amp;lt;15% (RVESVi: <jats:italic>r<\/jats:italic>\u2009=\u20090.40, <jats:italic>p<\/jats:italic>\u2009=\u20090.001; RVEDVi: <jats:italic>r<\/jats:italic>\u2009=\u20090.34, <jats:italic>p<\/jats:italic>\u2009=\u20090.031).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Assessment of serial CMR studies in HLHS patients after TCPC completion demonstrates a preserved neo-aortic valve function. Nevertheless, thorough follow-up is mandatory as even mild neo-aortic dysfunction might impact RV size and function over a longer term.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2024.1466982","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T06:11:02Z","timestamp":1730787062000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The neo-aortic valve in patients with hypoplastic left heart syndrome is largely preserved: a serial follow-up CMR study"],"prefix":"10.3389","volume":"11","author":[{"given":"Abigail","family":"Burleigh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik 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