{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:12:50Z","timestamp":1778692370208,"version":"3.51.4"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970286"],"award-info":[{"award-number":["81970286"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>A previous investigation reported that an abnormal P-wave terminal force in lead V1 (PTFV1) is a marker for electrical remodeling of the left atrium (LA). We aimed to assess the relationship of PTFV1 with LA tachyarrhythmia (LATA) recurrence after radiofrequency catheter ablation (RFCA) in patients with paroxysmal atrial fibrillation (PAF) and normal LA size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with PAF and normal LA size (LA volume index\u2009&amp;lt;\u200934\u2005ml\/m<jats:sup>2<\/jats:sup>) who underwent RFCA were consecutively included between January 2018 and December 2020 and divided into two groups based on the presence (recurrence group) or absence (nonrecurrence group) of LATA recurrence. PTFV1 was measured according to preprocedural electrocardiography. The association between PTFV1 and the recurrence of LATA was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 385 patients were included. After a median follow-up period of 745 (467, 977) days, 109 (28.3%) patients experienced LATA recurrence. PTFV1 was greater in the recurrence group. Multivariate Cox regression analysis demonstrated that the hazard ratio and 95% confidence interval for PTFV1 per 1,000\u2005\u03bcV*ms increase and PTFV1\u2009&amp;gt;\u20094,000\u2005\u03bcV*ms were 1.22 (1.13\u20131.32, <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001) and 2.32 (1.54\u20133.48, <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PTFV1 is an independent predictor for LATA recurrence after RFCA in patients with PAF and normal LA size.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2024.1467585","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T04:42:52Z","timestamp":1728535372000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["P-wave terminal force in lead V1 is associated with recurrence after catheter ablation in patients with paroxysmal atrial fibrillation and normal left atrial size"],"prefix":"10.3389","volume":"11","author":[{"given":"Zhao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binhao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Che","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunlong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e143","DOI":"10.1161\/CIRCULATIONAHA.112.129759","article-title":"An update on the prognosis of patients with atrial fibrillation","volume":"126","author":"McManus","year":"2012","journal-title":"Circulation"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1161\/CIR.0000000000001193","article-title":"2023 ACC\/AHA\/ACCP\/HRS guideline for the diagnosis and management of atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines","volume":"149","author":"Joglar","year":"2024","journal-title":"Circulation"},{"key":"B3","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1161\/CIRCEP.109.923771","article-title":"Long-term outcome after successful catheter ablation of atrial fibrillation","volume":"3","author":"Tzou","year":"2010","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e004549","DOI":"10.1161\/JAHA.112.004549","article-title":"Long-term outcomes of catheter ablation of atrial fibrillation: a systematic review and meta-analysis","volume":"2","author":"Ganesan","year":"2013","journal-title":"J Am Heart Assoc"},{"key":"B5","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.jjcc.2021.08.004","article-title":"Clinical impact of very early recurrence of atrial fibrillation after radiofrequency catheter ablation","volume":"78","author":"Ukita","year":"2021","journal-title":"J Cardiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1111\/j.1540-8167.2010.01786.x","article-title":"Long-term outcome of atrial fibrillation ablation: impact and predictors of very late recurrence","volume":"21","author":"Wokhlu","year":"2010","journal-title":"J Cardiovasc Electrophysiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1177\/0300060519828522","article-title":"Radiofrequency catheter ablation for paroxysmal atrial fibrillation: outcomes during a 3-year follow-up period","volume":"47","author":"Wang","year":"2019","journal-title":"J Int Med Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"4863","DOI":"10.3390\/jcm10214863","article-title":"The effect of diabetes mellitus on the recurrence of atrial fibrillation after ablation","volume":"10","author":"Guckel","year":"2021","journal-title":"J Clin Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1097\/HCO.0b013e328341398e","article-title":"The role of obesity and sleep apnea in atrial fibrillation","volume":"26","author":"Needleman","year":"2011","journal-title":"Curr Opin Cardiol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1093\/europace\/euq434","article-title":"Predictors of recurrence following radiofrequency ablation for persistent atrial fibrillation","volume":"13","author":"McCready","year":"2011","journal-title":"Europace"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1136\/hrt.2009.191460","article-title":"Predicting atrial fibrillation recurrence with circulating inflammatory markers in patients in Sinus rhythm at high risk for atrial fibrillation: data from the GISSI atrial fibrillation trial","volume":"96","author":"Masson","year":"2010","journal-title":"Heart"},{"key":"B12","doi-asserted-by":"publisher","first-page":"368","DOI":"10.4070\/kcj.2021.0323","article-title":"Electrical remodeling of left atrium is a better predictor for recurrence than structural remodeling in atrial fibrillation patients undergoing radiofrequency catheter ablation","volume":"52","author":"Kim","year":"2022","journal-title":"Korean Circ J"},{"key":"B13","doi-asserted-by":"publisher","first-page":"4055","DOI":"10.1002\/ehf2.13488","article-title":"Abnormal P-wave terminal force in lead V1 is a marker for atrial electrical dysfunction but not structural remodelling","volume":"8","author":"Lebek","year":"2021","journal-title":"ESC Heart Fail"},{"key":"B14","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1378\/chest.09-1584","article-title":"Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation","volume":"137","author":"Lip","year":"2010","journal-title":"Chest"},{"key":"B15","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American society of echocardiography and the European association of cardiovascular imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"B16","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1002\/ana.24482","article-title":"Electrocardiographic left atrial abnormality and stroke subtype in the atherosclerosis risk in communities study","volume":"78","author":"Kamel","year":"2015","journal-title":"Ann Neurol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s12872-021-01930-w","article-title":"Effectiveness of P-wave ECG Index and left atrial appendage volume in predicting atrial fibrillation recurrence after first radiofrequency catheter ablation","volume":"21","author":"Li","year":"2021","journal-title":"BMC Cardiovasc Disord"},{"key":"B18","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ejim.2022.04.019","article-title":"Atrial cardiomyopathy markers and new-onset atrial fibrillation risk in patients with acute myocardial infarction","volume":"102","author":"Li","year":"2022","journal-title":"Eur J Intern Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/s0008-6363(02)00258-4","article-title":"Electrical, contractile and structural remodeling during atrial fibrillation","volume":"54","author":"Allessie","year":"2002","journal-title":"Cardiovasc Res"},{"key":"B20","doi-asserted-by":"publisher","first-page":"889","DOI":"10.21873\/invivo.11854","article-title":"Recurrence of atrial fibrillation in dependence of left atrial volume Index","volume":"34","author":"Kranert","year":"2020","journal-title":"In Vivo"},{"key":"B21","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1093\/europace\/eux013","article-title":"Left atrial volume predicts atrial fibrillation recurrence after radiofrequency ablation: a meta-analysis","volume":"20","author":"Njoku","year":"2018","journal-title":"Europace"},{"key":"B22","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s10554-017-1243-7","article-title":"Left atrial volume computed by 3D rotational angiography best predicts atrial fibrillation recurrence after circumferential pulmonary vein isolation","volume":"34","author":"Strisciuglio","year":"2018","journal-title":"Int J Cardiovasc Imaging"},{"key":"B23","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1093\/europace\/euv028","article-title":"Low P-wave amplitude <0.1 MV) in lead I is associated with displaced inter-atrial conduction and clinical recurrence of paroxysmal atrial fibrillation after radiofrequency catheter ablation","volume":"18","author":"Park","year":"2016","journal-title":"Europace"},{"key":"B24","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s10840-011-9641-6","article-title":"Predictive value of left atrial volume measured by non-invasive cardiac imaging in the treatment of paroxysmal atrial fibrillation","volume":"34","author":"von Bary","year":"2012","journal-title":"J Interv Card Electrophysiol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.ipej.2016.11.002","article-title":"Electrophysiological abnormalities in patients with paroxysmal atrial fibrillation in the absence of overt structural heart disease","volume":"16","author":"Arroja","year":"2016","journal-title":"Indian Pacing Electrophysiol J"},{"key":"B26","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.hrthm.2014.12.007","article-title":"Mechanical and substrate abnormalities of the left atrium assessed by 3-dimensional speckle-tracking echocardiography and electroanatomic mapping system in patients with paroxysmal atrial fibrillation","volume":"12","author":"Watanabe","year":"2015","journal-title":"Heart Rhythm"},{"key":"B27","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jacc.2004.10.035","article-title":"Pre-existent left atrial scarring in patients undergoing pulmonary vein antrum isolation: an independent predictor of procedural failure","volume":"45","author":"Verma","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e12653","DOI":"10.1111\/anec.12653","article-title":"Prolonged P-wave duration in sinus rhythm Pre-ablation is associated with atrial fibrillation recurrence after pulmonary vein isolation\u2014a systematic review and meta-analysis","volume":"24","author":"Pranata","year":"2019","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.jacep.2017.12.001","article-title":"The duration of the amplified sinus-P-wave identifies presence of left atrial low voltage substrate and predicts outcome after pulmonary vein isolation in patients with persistent atrial fibrillation","volume":"4","author":"Jadidi","year":"2018","journal-title":"JACC Clin Electrophysiol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1007\/s00392-019-01590-z","article-title":"Amplified P-wave duration predicts new-onset atrial fibrillation in patients with heart failure with preserved ejection fraction","volume":"109","author":"M\u00fcller-Edenborn","year":"2020","journal-title":"Clin Res Cardiol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1110165","DOI":"10.3389\/fcvm.2023.1110165","article-title":"Amplified sinus-P-wave analysis predicts outcomes of cryoballoon ablation in patients with persistent and long-standing persistent atrial fibrillation: a multicentre study","volume":"10","author":"Creta","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1038\/s41440-021-00713-2","article-title":"Effect of intensive blood pressure lowering on left atrial remodeling in the SPRINT","volume":"44","author":"Kamel","year":"2021","journal-title":"Hypertens Res"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1161\/CIRCEP.114.001557","article-title":"Prevalence and prognostic significance of abnormal P terminal force in lead V1 of the ECG in the general population","volume":"7","author":"Eranti","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.06.031","article-title":"P-wave terminal force in lead V1 predicts paroxysmal atrial fibrillation in acute ischemic stroke","volume":"26","author":"Goda","year":"2017","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"B35","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.recesp.2011.04.023","article-title":"P wave morphology and recurrence after cardioversion of lone atrial fibrillation","volume":"65","author":"Garc\u00eda","year":"2012","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1007\/s10840-023-01710-w","article-title":"Association between P-wave terminal force in lead V1 and extent of left atrial low-voltage substrate in older patients with paroxysmal atrial fibrillation","volume":"67","author":"Qiu","year":"2024","journal-title":"J Interv Card Electrophysiol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.ahj.2023.03.006","article-title":"P-wave terminal force in lead V1 and outcomes in patients with persistent atrial fibrillation undergoing catheter ablation","volume":"260","author":"Sudo","year":"2023","journal-title":"Am Heart J"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1467585\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T04:42:54Z","timestamp":1728535374000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1467585\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,10]]},"references-count":37,"alternative-id":["10.3389\/fcvm.2024.1467585"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2024.1467585","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,10]]},"article-number":"1467585"}}