{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:50:44Z","timestamp":1753890644117,"version":"3.41.2"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiomyopathy characterized by high risks of sustained ventricular tachycardia (sVT) and sudden cardiac death. Identifying patients with high risk of sVT is crucial for the management of ACM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 147 ACM patients were retrospectively enrolled in the observational study and divided into training and validation groups. The least absolute shrinkage and selection operator (LASSO) regression model was employed to identify factors associated with sVT. Subsequently, a nomogram was constructed based on multivariable logistic regression analysis. The performance of the nomogram was evaluated using the area under the curve (AUC) of the receiver operating characteristic (ROC) curve and calibration curve. Decision curve analysis was conducted to assess the clinical utility of the nomogram.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven parameters were incorporated into the nomogram: age, male sex, syncope, heart failure, T wave inversion in precordial leads, left ventricular ejection fraction (LVEF), SDNN level. The AUC of the nomogram to predict the probability of sVT was 0.867 (95% CI, 0.797\u20130.938) in the training group and 0.815 (95% CI, 0.673\u20130.958) in the validation group. The calibration curve demonstrated a good consistency between the actual clinical results and the predicted outcomes. Decision curve analysis indicated that the nomogram had higher overall net benefits in predicting sVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We have developed and internally validated a new prediction model for sVT in ACM. This model could serve as a valuable tool to accurately identify ACM patients with high risk of sVT.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2024.1477931","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T06:18:57Z","timestamp":1734329937000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A new prediction model for sustained ventricular tachycardia in arrhythmogenic cardiomyopathy"],"prefix":"10.3389","volume":"11","author":[{"given":"Baowei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinbo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizhang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaorong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1056\/NEJMra1509267","article-title":"Arrhythmogenic right ventricular cardiomyopathy","volume":"376","author":"Corrado","year":"2017","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/j.jacc.2023.01.041","article-title":"Sudden cardiac death among adolescents in the United Kingdom","volume":"81","author":"Finocchiaro","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1186\/s12916-024-03593-8","article-title":"Hyperactivation of ATF4\/TGF-beta1 signaling contributes to the progressive cardiac fibrosis in arrhythmogenic cardiomyopathy caused by DSG2 variant","volume":"22","author":"Zhang","year":"2024","journal-title":"BMC Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"3997","DOI":"10.1093\/eurheartj\/ehac262","article-title":"2022 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death","volume":"43","author":"Zeppenfeld","year":"2022","journal-title":"Eur Heart J"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60010094","article-title":"Inherited arrhythmias in the pediatric population: an updated overview","volume":"60","author":"Mariani","year":"2024","journal-title":"Medicina (Kaunas)"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e301","DOI":"10.1016\/j.hrthm.2019.05.007","article-title":"2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy","volume":"16","author":"Towbin","year":"2019","journal-title":"Heart Rhythm"},{"key":"B7","doi-asserted-by":"publisher","first-page":"26","DOI":"10.15420\/aer.2020.39","article-title":"Risk stratification in arrhythmogenic right ventricular cardiomyopathy","volume":"10","author":"Wallace","year":"2021","journal-title":"Arrhythm Electrophysiol Rev"},{"key":"B8","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1136\/heartjnl-2021-319113","article-title":"Arrhythmogenic right ventricular cardiomyopathy: a focused update on diagnosis and risk stratification","volume":"108","author":"Bosman","year":"2022","journal-title":"Heart"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1093\/eurheartj\/ehz103","article-title":"A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy","volume":"40","author":"Cadrin-Tourigny","year":"2019","journal-title":"Eur Heart J"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac180","article-title":"A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy","author":"Cadrin-Tourigny","year":"2022","journal-title":"Eur Heart J"},{"key":"B11","doi-asserted-by":"publisher","first-page":"3053","DOI":"10.1093\/eurheartj\/ehac235","article-title":"Importance of genotype for risk stratification in arrhythmogenic right ventricular cardiomyopathy using the 2019 ARVC risk calculator","volume":"43","author":"Protonotarios","year":"2022","journal-title":"Eur Heart J"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.1016\/j.jacc.2020.04.023","article-title":"Prognostic value of magnetic resonance phenotype in patients with arrhythmogenic right ventricular cardiomyopathy","volume":"75","author":"Aquaro","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1093\/europace\/euz352","article-title":"Long-term follow-up analysis of a highly characterized arrhythmogenic cardiomyopathy cohort with classical and non-classical phenotypes-a real-world assessment of a novel prediction model: does the subtype really matter","volume":"22","author":"Casella","year":"2020","journal-title":"Europace"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.hrthm.2019.01.019","article-title":"Cardiac sympathectomy for refractory ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy","volume":"16","author":"Assis","year":"2019","journal-title":"Heart Rhythm"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1044797","DOI":"10.3389\/fcvm.2022.1044797","article-title":"Impaired heart rate variability in patients with arrhythmogenic cardiomyopathy: a multicenter retrospective study in China","volume":"9","author":"Zhang","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1093\/eurheartj\/ehq025","article-title":"Diagnosis of arrhythmogenic right ventricular cardiomyopathy\/dysplasia: proposed modification of the task force criteria","volume":"31","author":"Marcus","year":"2010","journal-title":"Eur Heart J"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e24174","DOI":"10.1002\/clc.24174","article-title":"The significance of heart rate variability in patients with frequent premature ventricular complex originating from the ventricular outflow tract","volume":"47","author":"Zhang","year":"2024","journal-title":"Clin Cardiol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1016\/j.jacc.2011.06.043","article-title":"Incidence and predictors of implantable cardioverter-defibrillator therapy in patients with arrhythmogenic right ventricular dysplasia\/cardiomyopathy undergoing implantable cardioverter-defibrillator implantation for primary prevention","volume":"58","author":"Bhonsale","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1046\/j.1460-9592.2002.01285.x","article-title":"Heart rate variability in arrhythmogenic right ventricular cardiomyopathy correlation with clinical and prognostic features","volume":"25","author":"Folino","year":"2002","journal-title":"Pacing Clin Electrophysiol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1161\/CIRCULATIONAHA.117.030792","article-title":"Risk stratification in arrhythmogenic right ventricular cardiomyopathy","volume":"136","author":"Calkins","year":"2017","journal-title":"Circulation"},{"key":"B21","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/s41569-019-0200-7","article-title":"Molecular mechanisms of arrhythmogenic cardiomyopathy","volume":"16","author":"Austin","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1093\/ehjci\/jez277","article-title":"Myocardial fibrosis in arrhythmogenic cardiomyopathy: a genotype-phenotype correlation study","volume":"21","author":"Segura-Rodriguez","year":"2020","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1093\/cvr\/cvaa084","article-title":"Arrhythmogenic cardiomyopathy: pathogenesis, pro-arrhythmic remodelling, and novel approaches for risk stratification and therapy","volume":"116","author":"van der Voorn","year":"2020","journal-title":"Cardiovasc Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.hrthm.2012.11.018","article-title":"Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy","volume":"10","author":"Noorman","year":"2013","journal-title":"Heart Rhythm"},{"key":"B25","doi-asserted-by":"publisher","first-page":"115448","DOI":"10.1016\/j.biopha.2023.115448","article-title":"Molecular insight into arrhythmogenic cardiomyopathy caused by DSG2 mutations","volume":"167","author":"Zhang","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"B26","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.jacep.2021.12.002","article-title":"Arrhythmogenic right ventricular Cardiomyopathy","volume":"8","author":"Krahn","year":"2022","journal-title":"JACC Clin Electrophysiol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/s41467-017-00127-0","article-title":"Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm","volume":"8","author":"Cerrone","year":"2017","journal-title":"Nat Commun"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1161\/CIRCULATIONAHA.119.039710","article-title":"Disruption of ca(2+)i homeostasis and connexin 43 hemichannel function in the right ventricle precedes overt arrhythmogenic cardiomyopathy in plakophilin-2-deficient mice","volume":"140","author":"Kim","year":"2019","journal-title":"Circulation"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/j.hrthm.2019.02.004","article-title":"The sympathetic nervous system and arrhythmogenic right ventricular cardiomyopathy: further evidence of a strong tie","volume":"16","author":"Dusi","year":"2019","journal-title":"Heart Rhythm"},{"key":"B30","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1161\/01.CIR.89.2.667","article-title":"Regional myocardial sympathetic dysinnervation in arrhythmogenic right ventricular cardiomyopathy. An analysis using 123I-meta-iodobenzylguanidine scintigraphy","volume":"89","author":"Wichter","year":"1994","journal-title":"Circulation"},{"key":"B31","doi-asserted-by":"publisher","first-page":"3626","DOI":"10.1093\/eurheartj\/ehy600","article-title":"Treatments targeting inotropy","volume":"40","author":"Maack","year":"2019","journal-title":"Eur Heart J"},{"key":"B32","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/s41569-019-0221-2","article-title":"The autonomic nervous system and cardiac arrhythmias: current concepts and emerging therapies","volume":"16","author":"Herring","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jacc.2014.04.035","article-title":"Ventricular arrhythmias in the north American multidisciplinary study of ARVC: predictors, characteristics, and treatment","volume":"64","author":"Link","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1016\/j.jacc.2016.09.951","article-title":"Arrhythmogenic right ventricular cardiomyopathy: clinical course and predictors of arrhythmic risk","volume":"68","author":"Mazzanti","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1161\/CIRCULATIONAHA.109.913871","article-title":"Prophylactic implantable defibrillator in patients with arrhythmogenic right ventricular cardiomyopathy\/dysplasia and no prior ventricular fibrillation or sustained ventricular tachycardia","volume":"122","author":"Corrado","year":"2010","journal-title":"Circulation"},{"key":"B36","doi-asserted-by":"publisher","first-page":"3084","DOI":"10.1161\/01.CIR.0000103130.33451.D2","article-title":"Implantable cardioverter-defibrillator therapy for prevention of sudden death in patients with arrhythmogenic right ventricular cardiomyopathy\/dysplasia","volume":"108","author":"Corrado","year":"2003","journal-title":"Circulation"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e45850","DOI":"10.7759\/cureus.45850","article-title":"Recurrent syncope in a patient with arrhythmogenic right ventricular cardiomyopathy","volume":"15","author":"Castillo","year":"2023","journal-title":"Cureus"},{"key":"B38","doi-asserted-by":"publisher","first-page":"131447","DOI":"10.1016\/j.ijcard.2023.131447","article-title":"Proposed diagnostic criteria for arrhythmogenic cardiomyopathy: european task force consensus report","volume":"395","author":"Corrado","year":"2024","journal-title":"Int J Cardiol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.hroo.2021.07.009","article-title":"The RV(1)-V(3) transition ratio: a novel electrocardiographic criterion for the differentiation of right versus left outflow tract premature ventricular complexes","volume":"2","author":"Efremidis","year":"2021","journal-title":"Heart Rhythm O2"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1093\/europace\/euac267","article-title":"Electrocardiographic findings in patients with arrhythmogenic cardiomyopathy and right bundle branch block ventricular tachycardia","volume":"25","author":"Laredo","year":"2023","journal-title":"Europace"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.33963\/v.phj.102391","article-title":"Arrhythmogenic right ventricular cardiomyopathies (ARVC): diagnostic challenges from imaging to genetics","author":"Casian","year":"2024","journal-title":"Kardiol Pol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"e003672","DOI":"10.1161\/CIRCGEN.121.003672","article-title":"Variant location is a novel risk factor for individuals with arrhythmogenic cardiomyopathy due to a desmoplakin (DSP) truncating variant","volume":"16","author":"Hoorntje","year":"2023","journal-title":"Circ Genom Precis Med"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1477931\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T06:18:59Z","timestamp":1734329939000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1477931\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":42,"alternative-id":["10.3389\/fcvm.2024.1477931"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2024.1477931","relation":{},"ISSN":["2297-055X"],"issn-type":[{"type":"electronic","value":"2297-055X"}],"subject":[],"published":{"date-parts":[[2024,12,16]]},"article-number":"1477931"}}