{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:09:41Z","timestamp":1790208581313,"version":"4.1.0"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p><jats:italic>Fusarium<\/jats:italic>, a genus of soil and vegetation-based fungi, is a rare cause of infections in immunocompromised individuals, including transplant recipients. In this case, we describe successful treatment of <jats:italic>Fusarium falciforme<\/jats:italic> mediastinitis in the recipient of an orthotopic heart transplant. Treatment included multiple courses of combination antibiotic and antifungal therapy several surgical debridements, continuous mediastinal irrigation with antifungal agents, and staged closure with an omental flap. This is the first report describing successful eradication of <jats:italic>fusarium sp.<\/jats:italic> mediastinitis and provides a template for treating complex cases of mediastinitis and osteomyelitis.<\/jats:p>","DOI":"10.3389\/fcvm.2024.1480392","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T05:15:47Z","timestamp":1736140547000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Fusarium falciforme pericardial and sternal wound infection following orthotopic heart transplantation"],"prefix":"10.3389","volume":"11","author":[{"given":"Jeffrey","family":"Rodgers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanford","family":"Zeigler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1128\/CMR.00014-07","article-title":"Fusarium infections in immunocompromised patients","volume":"20","author":"Nucci","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1016\/j.transproceed.2012.09.059","article-title":"Risk factors, clinical characteristics, and outcomes of invasive fungal infections in solid organ transplant recipients","volume":"44","author":"Bodro","year":"2012","journal-title":"Transplant Proc"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3973","DOI":"10.1128\/AAC.05035-14","article-title":"Optimization of polyene-azole combination therapy against aspergillosis using an in vitro pharmacokinetic-pharmacodynamic model","volume":"59","author":"Siopi","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1086\/319753\/2\/32-8-1237-TBL002","article-title":"Fusarium infection after solid-organ transplantation","volume":"32","author":"Sampathkumar","year":"2001","journal-title":"Clin Infect Dis"},{"key":"B5","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/J.1365-2133.2007.08020.X","article-title":"Fatal disseminated angioinvasive Fusarium falciforme infection in a patient with acute myeloid leukaemia","volume":"157","author":"Yun","year":"2007","journal-title":"Br J Dermatol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e12872","DOI":"10.1111\/TID.12872","article-title":"Fatal Fusarium infection manifesting as osteomyelitis following previous treatment with amphotericin B in a multi-visceral transplant: case report and review of Fusarium infections in solid organ transplantation","volume":"20","author":"Nambiar","year":"2018","journal-title":"Transpl Infect Dis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1097\/01.INF.0000143649.90952.41","article-title":"Fusarium solani endocarditis successfully treated with liposomal amphotericin B and voriconazole","volume":"23","author":"Guzman-Cottrill","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e107","DOI":"10.1055\/s-0043-1775559","article-title":"Efficacy of continuous saline irrigation therapy for descending necrotizing mediastinitis","volume":"9","author":"Ohashi","year":"2023","journal-title":"Surg J"},{"key":"B9","doi-asserted-by":"publisher","first-page":"101468","DOI":"10.1016\/J.EUCR.2020.101468","article-title":"Successfully treated bilateral renal fungal balls with continuous Anidulafulgin irrigation","volume":"34","author":"van Merode","year":"2021","journal-title":"Urol Case Rep"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.21470\/1678-9741-2020-0040","article-title":"Two-stage omental flap approach for ascending aortic graft infection","volume":"35","author":"Andrade","year":"2020","journal-title":"Braz J Cardiovasc Surg"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1480392\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T05:15:49Z","timestamp":1736140549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2024.1480392\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,6]]},"references-count":10,"alternative-id":["10.3389\/fcvm.2024.1480392"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2024.1480392","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,6]]},"article-number":"1480392"}}