{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:54:38Z","timestamp":1785801278343,"version":"3.56.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cardioneuroablation (CNA) is a new approach to treat reflex syncope and functional bradyarrhytmias caused by autonomic imbalance. We report our experience using CNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>From September 2022 to July 2023, we took care of 21 patients (mean age 42\u2009\u00b1\u200921 years; 62% male) affected by reflex syncope or functional bradyarrhythmias. All patients underwent CNA under conscious sedation targeting the superior and\/or inferior paraseptal ganglionated plexus (GPs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine patients were affected by vasovagal syncope (VVS) and twelve by functional bradyarrhythmias. In 3 cases (14%) the ablation was performed only on the GPs of the right atrium, while in the remaining 86% of cases we performed biatrial lesions. As regards the acute results, we highlighted an increase in sinus heart rate (12\u2009\u00b1\u200915 bpm, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), a shortening of the PQ interval (\u221218\u2009\u00b1\u200918\u2005msec, <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001), a reduction of the correct sinus node recovery times (cSNRT) (\u2212142\u2009\u00b1\u2009204\u2005msec, <jats:italic>p<\/jats:italic>\u2009=\u20090.114), a shortening of the AH interval (\u221231\u2009\u00b1\u200926\u2005msec, <jats:italic>p<\/jats:italic>\u2009=\u20090.008), a reduction of the effective refractory period of the atrio-ventricular node (\u2212156; interquartile range from \u221230 to \u2212160\u2005msec, <jats:italic>p<\/jats:italic>\u2009=\u20090.042) and an increase in the Wencheback point (27\u2009\u00b1\u200920 bpm, <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001). At follow-up, a single patient, due to persistent symptoms and bradyarrhythmic disorder, underwent permanent pacemaker implantation; no other patient had recurrence of syncope, and all remained persistently asymptomatic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results confirm the efficacy and safety of CNA for the treatment of VVS and functional bradyarrhythmias, although further studies are needed to support these findings.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2024.1526825","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T06:12:11Z","timestamp":1736748731000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Cardioneuroablation for reflex syncope or functional bradyarrhytmias: new insight from a single center 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