{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:49:56Z","timestamp":1753890596352,"version":"3.41.2"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>It is crucial to investigate whether there are prognostic disparities among AMI-CS patients undergoing VA-ECMO support. However, there is currently limited data available from China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the gender differences in the characteristics, management, and outcomes among patients with AMI-CS received VA-ECMO support in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients admitted with AMI-CS at the Chest Pain Center of Guangxi Zhuang Autonomous Region People's Hospital between 2018 and 2023 were included. Sex differences in baseline characteristics, in-hospital management, and outcomes were compared. The primary endpoint was in-hospital mortality. Propensity score matching (PSM) was performed to reduce the impact of baseline clinical differences. Cox regression analysis was conducted to assess the association between gender and in-hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 193 patients presenting with AMI-CS, 15.54% were women. Women were older (67.23\u2009\u00b1\u200913 vs. 60.37\u2009\u00b1\u200912.98, <jats:italic>p<\/jats:italic>\u2009=\u20090.0028), had a higher prevalence of comorbidities, and a lower proportion of smoking history. Women were less likely to receive vascular reconstruction (70% vs. 88%, <jats:italic>p<\/jats:italic>\u2009=\u20090.023), had a significantly shorter duration of ECMO support (2.72 days vs. 4.87 days, <jats:italic>p<\/jats:italic>\u2009=\u20090.027), as well as shorter hospitalization days compared to male patients (11.73\u2009\u00b1\u200910.52 vs. 16.89\u2009\u00b1\u200910.74, <jats:italic>p<\/jats:italic>\u2009=\u20090.026). In-hospital all-cause mortality was notably higher among female patients (90.0%) compared to male patients (71.2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.023). However, after PSM, the difference in in-hospital mortality rates between genders was not statistically significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.16).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this retrospective study, women were less likely to receive revascularization and exhibited worse in-hospital outcomes compared to men. However, the observed sex difference in in-hospital mortality was attenuated after adjusting for clinical characteristics and acute treatments among AMI-CS patients receiving ECMO support.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2025.1461580","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T05:27:05Z","timestamp":1747891625000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gender disparities in patients treated with veno-arterial ECMO for cardiogenic shock complicating acute myocardial infarction"],"prefix":"10.3389","volume":"12","author":[{"given":"Lingyue","family":"Qiu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingzhong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiying","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingkuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiyong","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhua","family":"Mo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qili","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xubin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengde","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guozheng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwen","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingwei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1001\/jama.2021.18323","article-title":"Cardiogenic shock after acute myocardial infarction: a review","volume":"326","author":"Samsky","year":"2021","journal-title":"JAMA"},{"key":"B2","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1097\/SHK.0000000000001895","article-title":"Cardiogenic shock complicating ST-segment elevation myocardial infarction: an 18-year analysis of temporal trends, epidemiology, management, and outcomes","volume":"57","author":"Vallabhajosyula","year":"2022","journal-title":"Shock"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e001250","DOI":"10.1161\/JAHA.114.001250","article-title":"Trends in early aspirin use among patients with acute myocardial infarction in China, 2001\u20132011: the China PEACE-retrospective AMI study","volume":"3","author":"Gao","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"B4","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/S0140-6736(14)60921-1","article-title":"ST-segment elevation myocardial infarction in China from 2001 to 2011 (the China PEACE-Retrospective acute myocardial infarction study): a retrospective analysis of hospital data","volume":"385","author":"Li","year":"2015","journal-title":"Lancet"},{"key":"B5","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1056\/NEJM199908263410901","article-title":"Early revascularization in acute myocardial infarction complicated by cardiogenic shock. 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