{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T07:29:49Z","timestamp":1783582189656,"version":"3.55.0"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Left ventricular (LV) guidewire pacing has been proven to be a safe and effective pacing mode for transcatheter aortic valve replacement (TAVR). However, the high pacing voltage threshold and impedance of LV guidewire pacing are potential risks for loss of capture and valve embolization. Moreover, decisions surrounding whether and when to perform percutaneous coronary intervention (PCI) are always heterogeneous in patients with severe aortic stenosis and coronary artery disease. As described in this case report, we attempted an optimized LV guidewire pacing mode with the lowest pacing voltage threshold and impedance, avoiding complications associated with additional vascular access and further reducing TAVR costs. In addition, we successfully performed simultaneous PCI in this patient with a vertically downward orifice of the right coronary artery (RCA), severe calcified stenosis in the RCA, horizocardia, and a dilated ascending aorta. This case report provides new evidence for LV guidewire pacing and the opportunity for PCI in TAVR procedures.<\/jats:p>","DOI":"10.3389\/fcvm.2025.1515954","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T05:38:04Z","timestamp":1753940284000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Optimized guidewire pacing in transcatheter aortic valve replacement combined with complex PCI in a patient with severe aortic stenosis and regurgitation"],"prefix":"10.3389","volume":"12","author":[{"given":"Ruisong","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.carrev.2024.05.003","article-title":"Impact of coronary artery disease and revascularization on outcomes of transcatheter aortic valve replacement for severe aortic stenosis","volume":"68","author":"Yamashita","year":"2024","journal-title":"Cardiovasc Revasc Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.3390\/jcm9041017","article-title":"Direct rapid left ventricular wire pacing during balloon aortic valvuloplasty","volume":"9","author":"Kleczynski","year":"2020","journal-title":"J Clin Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.cjca.2023.09.023","article-title":"Aortic stenosis with coronary artery disease: SAVR or TAVR\u2014when and how?","volume":"40","author":"del Portillo","year":"2024","journal-title":"Can J Cardiol"},{"key":"B4","first-page":"19","article-title":"Recurrent respiratory papillomatosis in children: a retrospective study of management and complications","volume":"65","author":"Morgan","year":"1986","journal-title":"Ear Nose Throat J"},{"key":"B5","first-page":"139","article-title":"Daily travel of Sundanese mothers in an agricultural community of West Java: evidence of restriction by childcare","volume":"15","author":"Takasaka","year":"1986","journal-title":"J Hum Ergol (Tokyo)"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1016\/j.jcin.2022.07.002","article-title":"The dilemma of CAD in TAVR candidates: useful to find it, useless to treat it?","volume":"15","author":"Stefanini","year":"2022","journal-title":"JACC Cardiovasc Interv"},{"key":"B7","doi-asserted-by":"publisher","first-page":"101339","DOI":"10.1016\/j.cpcardiol.2022.101339","article-title":"Clinical outcomes of revascularization with percutaneous coronary intervention prior to transcatheter aortic valve replacement: a comprehensive meta-analysis","volume":"47","author":"Altibi","year":"2022","journal-title":"Curr Probl Cardiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.xjon.2022.02.019","article-title":"Staged versus concomitant transcatheter aortic valve replacement and percutaneous coronary intervention: a national analysis","volume":"10","author":"Tran","year":"2022","journal-title":"JTCVS Open"},{"key":"B9","doi-asserted-by":"publisher","first-page":"92","DOI":"10.25270\/jic\/22.00254","article-title":"Short-and mid-term outcomes of complex and high-risk versus standard percutaneous coronary interventions in patients undergoing transcatheter aortic valve replacement a total of 276 consecutive patients with severe","volume":"35","author":"Kodra","year":"2023","journal-title":"Index J Invasive Cardiol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1097\/mca.0000000000001373","article-title":"Comparison of the outcomes of concurrent versus staged TAVR combined with PCI in patients with severe aortic stenosis and coronary artery disease: a systematic review and meta-analysis","volume":"35","author":"Zhang","year":"2024","journal-title":"Coron Artery Dis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s12928-020-00753-4","article-title":"A systematic review and meta-analysis of delayed coronary artery access for coronary angiography with or without percutaneous coronary intervention (PCI) in patients who underwent transcatheter aortic valve replacement (TAVR)","volume":"37","author":"Diaz","year":"2022","journal-title":"Cardiovasc Intervention Ther"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1016\/j.jcin.2019.09.029","article-title":"Left ventricular rapid pacing via the valve delivery guidewire in transcatheter aortic valve replacement","volume":"12","author":"Faurie","year":"2019","journal-title":"JACC Cardiovasc Interv"},{"key":"B13","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.ijcard.2022.05.035","article-title":"Comparison of left ventricular with right ventricular rapid pacing on tamponade during TAVI","volume":"360","author":"Savvoulidis","year":"2022","journal-title":"Int J Cardiol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s12928-020-00676-0","article-title":"A novel technique to avoid perforation of the right ventricle by the temporary pacing lead during transcatheter aortic valve implantation","volume":"36","author":"Tanaka","year":"2021","journal-title":"Cardiovasc Intervention Ther"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1383264","DOI":"10.3389\/fcvm.2024.1383264","article-title":"Case report of snare-assisted coaxiality optimized technique during valve deployment in patient with pure aortic regurgitation","volume":"11","author":"Yu","year":"2024","journal-title":"Front Cardiovasc Med"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1515954\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T05:38:07Z","timestamp":1753940287000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1515954\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,31]]},"references-count":15,"alternative-id":["10.3389\/fcvm.2025.1515954"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2025.1515954","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,31]]},"article-number":"1515954"}}