{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:51:32Z","timestamp":1753890692503,"version":"3.41.2"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Anti-melanoma differentiation-associated gene 5 dermatomyositis (anti-MDA5 Ab+ DM) is characterized by amyopathic DM with interstitial lung disease. Its impact on the right ventricle remains unclear. We aim to evaluate RV involvement in anti-MDA5 Ab+ DM patients using cardiovascular magnetic resonance (CMR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single-center, prospective cohort study included 43 anti-MDA5 Ab+ DM patients (24 males, mean age\u2009=\u200944.7\u2009\u00b1\u200911.1 years) and 30 age- and gender-matched healthy controls (18 males, mean age\u2009=\u200944.8\u2009\u00b1\u200910.4 years). All patients underwent CMR before treatment. RV functional parameters, including ejection fraction (RVEF), end-diastolic\/end-systolic remodeling index (RVEDRI\/RVESRI), and right ventricular long-axis strain (RV-LAS), and RV and LV T1 and T2 mapping were analyzed. Differences between the two groups were evaluated, and correlations with clinical data were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anti-MDA5 Ab+ DM patients exhibited a significant decrease in RVEF (45.7\u2009\u00b1\u20095.9% vs. 52.7\u2009\u00b1\u20096.6%, <jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.001) and RV-LAS across all techniques. Increased RVESRI (1.38\u2009\u00b1\u20090.14 vs. 1.29\u2009\u00b1\u20090.14, <jats:italic>P<\/jats:italic>\u2009=\u20090.031) indicated RV subclinical dysfunction. The RV and LV blood pool T2 ratio was elevated in patients (0.96\u2009\u00b1\u20090.02 vs. 0.94\u2009\u00b1\u20090.03, <jats:italic>P<\/jats:italic>\u2009=\u20090.007). Patients in the inflammatory marker-positive group exhibited significantly worse RV-LAS compared with the negative group. RV-LAS<jats:sub>Ins\/mid<\/jats:sub> negatively correlated with hsTnl levels (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.34, <jats:italic>P<\/jats:italic>\u2009=\u20090.026), and ferritin (FER) is moderately positively correlated with RV-LAS<jats:sub>LVapex\/peri<\/jats:sub> (<jats:italic>r<\/jats:italic>\u2009=\u20090.487, <jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>RV subclinical dysfunction is common in patients with anti-MDA5 Ab+ DM. RV parameters on CMR such as RV-LAS and RVESRI serve as valuable imaging markers for early detection and risk stratification. These findings underscore the importance of routine cardiac evaluation in anti-MDA5 Ab+ DM.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2025.1558800","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:42:07Z","timestamp":1746186127000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of right ventricular involvement in patients with anti-MDA5 Ab+ DM: a prospectively observational study with cardiac magnetic resonance 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