{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:48:48Z","timestamp":1753890528122,"version":"3.41.2"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Takotsubo syndrome (TTS) is an acute cardiac condition characterized by transient regional left ventricular systolic dysfunction. Traditionally, it has been associated with physical or psychological stressors. Clinically, the onset of TTS is similar to acute coronary syndrome, requiring appropriate differential diagnosis to distinguish between the two clinical entities. Its treatment is usually conservative, and the prognosis is generally favorable. We report the case of a 57-year-old woman who was referred to the Department of Rehabilitation after suffering a non-ST-segment elevation myocardial infarction. During her eighth physical rehabilitation session, she developed palpitations and hypertension. Initial telemetry monitoring showed ventricular bigeminy with extrasystoles, tachycardia episodes, and ST-segment elevation. She was admitted to the Department of Cardiology, and cardiac catheterization and subsequent coronary angiography were performed, revealing no incidence of coronary lesions. However, ventriculography demonstrated severe left ventricular dysfunction in the systolic phase, characterized by akinesia of the mid-apical segments. These findings were suggestive of Takotsubo syndrome, which was subsequently confirmed by cardiac magnetic resonance imaging.<\/jats:p>","DOI":"10.3389\/fcvm.2025.1560087","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T04:10:22Z","timestamp":1750738222000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Onset of Takotsubo syndrome during a heart rehabilitation session"],"prefix":"10.3389","volume":"12","author":[{"given":"Ana Bel\u00e9n","family":"Jim\u00e9nez-Jim\u00e9nez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Mu\u00f1oz-Paz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Ladera-Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngela","family":"Heredia-Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Caballero-Villarraso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Mayordomo-Riera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1016\/j.jacc.2018.07.072","article-title":"Stress cardiomyopathy diagnosis and treatment: JACC state-of-the-art review","volume":"72","author":"Medina de Chazal","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/ejhf.2400","article-title":"Pathophysiology of Takotsubo syndrome\u2014a joint scientific statement from the heart failure association Takotsubo syndrome study group and myocardial function working group of the European Society of Cardiology\u2014part 1: overview and the central role for catecholamines and sympathetic nervous system","volume":"24","author":"Omerovic","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"B3","first-page":"107","article-title":"A comparative retrospective study of patients with Takotsubo syndrome and acute coronary syndrome","volume":"23","author":"Moady","year":"2021","journal-title":"Isr Med Assoc J"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yjmcc.2024.04.009","article-title":"An update on the mechanisms of Takotsubo syndrome: \u201cat the end an acute coronary syndrome\u201d","volume":"191","author":"Crea","year":"2024","journal-title":"J Mol Cell Cardiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1286975","DOI":"10.3389\/fcvm.2023.1286975","article-title":"Comparative electrocardiographic analysis of midventricular and typical Takotsubo syndrome","volume":"10","author":"Padilla-Lopez","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"821067","DOI":"10.3389\/fcvm.2021.821067","article-title":"The role of cardiac magnetic resonance in myocardial infarction and non-obstructive coronary arteries","volume":"8","author":"Liang","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1177\/11795468211065782","article-title":"Takotsubo syndrome: a review of presentation, diagnosis and management","volume":"16","author":"Assad","year":"2022","journal-title":"Clin Med Insights Cardiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"38","DOI":"10.31083\/j.rcm2301038","article-title":"Takotsubo cardiomyopathy","volume":"23","author":"Matta","year":"2022","journal-title":"Rev Cardiovasc Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1136\/heartjnl-2020318028","article-title":"Survival and risk of recurrence of Takotsubo syndrome","volume":"107","author":"Lau","year":"2021","journal-title":"Heart"},{"key":"B10","doi-asserted-by":"publisher","first-page":"114","DOI":"10.55729\/2000-9666.1394","article-title":"An unlikely cause of chest pain: recurrent Takotsubo cardiomyopathy","volume":"14","author":"Colantonio","year":"2024","journal-title":"J Community Hosp Intern Med Perspect"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e73533","DOI":"10.7759\/cureus.73533","article-title":"A case of Takotsubo cardiomyopathy in a 65-year-old woman triggered by emotional stress","volume":"16","author":"Bader","year":"2024","journal-title":"Cureus"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e32384","DOI":"10.7759\/cureus.32384","article-title":"Emotional stress induced broken heart syndrome: a case report","volume":"14","author":"Wei Juan","year":"2022","journal-title":"Cureus"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1059638","DOI":"10.3389\/fcvm.2022.1059638","article-title":"Case report: Takotsubo syndrome induced by severe hypoglycemia","volume":"9","author":"Xia","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"225","DOI":"10.5811\/cpcem.2022.2.55463","article-title":"Takotsubo cardiomyopathy following traumatic hand amputation: a case report","volume":"6","author":"Bacro-Duverger","year":"2022","journal-title":"Clin Pract Cases Emerg Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"951882","DOI":"10.3389\/fcvm.2022.951882","article-title":"The impact of UEFA Euro 2020 football championship on Takotsubo syndrome: results of a multicenter national registry","volume":"9","author":"Polimeni","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"931054","DOI":"10.3389\/fcvm.2022.931054","article-title":"Case report: changes in the levels of stress hormones during Takotsubo syndrome","volume":"9","author":"Ruiz","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1093\/eurheartj\/ehad274","article-title":"Takotsubo syndrome is a coronary microvascular disease: experimental evidence","volume":"44","author":"Dong","year":"2023","journal-title":"Eur Heart J"},{"key":"B18","doi-asserted-by":"publisher","first-page":"691","DOI":"10.2459\/JCM.0000000000001528","article-title":"An update on Takotsubo syndrome","volume":"24","author":"Alim","year":"2023","journal-title":"J Cardiovasc Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"oeac009","DOI":"10.1093\/ehjopen\/oeac009","article-title":"Takotsubo syndrome and respiratory diseases: a systematic review","volume":"2","author":"Li","year":"2022","journal-title":"Eur Heart J Open"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1418316","DOI":"10.3389\/fcvm.2024.1418316","article-title":"Case report: asymptomatic SARS-COV2 infection triggering recurrent Takotsubo syndrome","volume":"11","author":"Dall'Ara","year":"2024","journal-title":"Front Cardiovasc Med"},{"key":"B21","doi-asserted-by":"publisher","first-page":"100990","DOI":"10.1016\/j.ijcha.2022.100990","article-title":"Update of Takotsubo cardiomyopathy: present experience and outlook for the future","volume":"39","author":"Bairashevskaia","year":"2022","journal-title":"Int J Cardiol Heart Vasc"},{"key":"B22","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.hrtlng.2020.12.006","article-title":"Cardiac rehabilitation in Takotsubo cardiomyopathy: predictors of utilization and effects of exercise training","volume":"50","author":"Gobeil","year":"2021","journal-title":"Heart Lung"},{"key":"B23","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s43044-024-00542-x","article-title":"Incidence of Takotsubo cardiomyopathy in patients with acute coronary syndrome: a single center retrospective analysis","volume":"76","author":"Poruban","year":"2024","journal-title":"Egypt Heart J"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1560087\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T04:10:23Z","timestamp":1750738223000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1560087\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":23,"alternative-id":["10.3389\/fcvm.2025.1560087"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2025.1560087","relation":{},"ISSN":["2297-055X"],"issn-type":[{"type":"electronic","value":"2297-055X"}],"subject":[],"published":{"date-parts":[[2025,6,24]]},"article-number":"1560087"}}