{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:50:18Z","timestamp":1753890618355,"version":"3.41.2"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Type A aortic dissection (AD) is a lethal situation with high mortality within short time after onset. We present here a rare hemodialysis patient whose condition was comorbid with unrepaired type A AD. The challenge we face is whether low-molecular-weight heparin (LMWH) should be used during dialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 72-year-old man with a history of hemodialysis for 2 years and 7 months sought medical attention due to thrombosis of the dialysis catheter. He had been diagnosed with an unrepaired type A aortic dissection (involving the aortic root, the ascending aorta, the aortic arch, the descending aorta, the abdominal aorta, the left common iliac artery, and the femoral artery) for more than 5 years. LMWH was not given during the previous dialysis process because of concerns about the rupture of the dissection. The lesion was salvaged via urokinase thrombolysis. However, the anticoagulant-free dialysis pattern occasionally caused dialyzer clotting and further increased the risk of catheter dysfunction. The patient repeatedly experienced dysfunction of the catheter in the following 8 months, with 2 episodes resolved via thrombolysis and 2 episodes replaced with new catheters. Finally, LMWH was used for each dialysis session to prevent thrombosis, with the dosage gradually increasing from 1,000 units to 2,000 units. The dosage of 2,000 units could support sufficient 4-hour dialysis for each session. Twenty-five months have passed since then, the patient has not experienced any further occlusion of the catheter, and the aortic dissection has not shown obvious changes (neither obvious expansion nor rupture).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reducing the dosage of LMWH during hemodialysis is a feasible solution to maintain a balance between hemodialysis access patency and stable dissection status in this particular patient.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2025.1561645","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T08:11:01Z","timestamp":1742803861000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Maintaining a balance between vascular access patency and stable dissection status in a hemodialysis patient with unrepaired type A aortic dissection"],"prefix":"10.3389","volume":"12","author":[{"given":"Qiquan","family":"Lai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongtao","family":"Tie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziming","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1016\/j.jtcvs.2018.09.020","article-title":"Differential outcomes of open and clamp-on distal anastomosis techniques in acute type A aortic dissection","volume":"157","author":"Geirsson","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1161\/CIRCULATIONAHA.117.031264","article-title":"Insights from the international registry of acute aortic dissection: a 20-year experience of collaborative clinical research","volume":"137","author":"Evangelista","year":"2018","journal-title":"Circulation"},{"key":"B3","doi-asserted-by":"publisher","first-page":"ivaf009","DOI":"10.1093\/icvts\/ivaf009","article-title":"Survival outcomes after surgery for type A aortic dissection: a contemporary Dutch nationwide registry study","volume":"40","author":"Timmermans","year":"2025","journal-title":"Interdiscip Cardiovasc Thorac Surg"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1307935","DOI":"10.3389\/fcvm.2023.1307935","article-title":"Baseline risk factors of in-hospital mortality after surgery for acute type A aortic dissection: an ERTAAD study","volume":"10","author":"Biancari","year":"2024","journal-title":"Front Cardiovasc Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.jacasi.2022.08.009","article-title":"Current surgical management of acute type A aortic dissection in China: a multicenter registry study","volume":"2","author":"Zhao","year":"2022","journal-title":"JACC Asia"},{"key":"B6","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/j.jtcvs.2018.11.021","article-title":"The fate of unrepaired chronic type A aortic dissection","volume":"158","author":"Kim","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B7","doi-asserted-by":"publisher","first-page":"726","DOI":"10.26574\/maedica.2023.18.4.726","article-title":"Aortic dissection: spectacular survival or nightmare?","volume":"18","author":"Nemtut","year":"2023","journal-title":"Maedica (Buchar)"},{"key":"B8","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1161\/CIRCULATIONAHA.121.056546","article-title":"Blood pressure, hypertension, and the risk of aortic dissection incidence and mortality: results from the J-SCH study, the UK biobank study, and a meta-analysis of cohort studies","volume":"145","author":"Hibino","year":"2022","journal-title":"Circulation"},{"key":"B9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12882-016-0231-9","article-title":"Prevalence of intradialytic hypotension, clinical symptoms and nursing interventions - 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