{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T17:19:05Z","timestamp":1779124745146,"version":"3.51.4"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with atrial fibrillation (AF) and atrial septal defect (ASD) face elevated thromboembolic risks, yet evidence on combined left atrial appendage closure (LAAC) and ASD closure remains limited. We aimed to assess the feasibility and safety of a \u201cone-stop\u201d strategy for simultaneous LAAC and ASD closure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis included 40 patients with non-valvular AF and ASD undergoing combined procedures (2016\u20132024). Procedural success, complications, and long-term outcomes (mean follow-up: 1,194.3 days) were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All procedures were technically successful. No major complications (stroke, device embolization, or death) occurred during follow-up. Peri-device leak (PDL) was observed in 19 patients (47.5%), with only one case of device-related thrombus (resolved with anticoagulation).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The \u201cone-stop\u201d approach is a safe and effective strategy for stroke prevention in AF patients with ASD, particularly those unsuitable for long-term anticoagulation.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2025.1579786","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T05:30:45Z","timestamp":1750311045000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["\u201cOne-stop\u201d combined percutaneous left atrial appendage and atrial septal defect closure in atrial fibrillation: safety and feasibility from a single-center cohort"],"prefix":"10.3389","volume":"12","author":[{"given":"Gaofeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiqiang","family":"Jie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kailing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dujiang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2660","DOI":"10.1093\/eurheartj\/ehab646","article-title":"Atrial septal defect in adulthood: a new paradigm for congenital heart disease","volume":"43","author":"Brida","year":"2022","journal-title":"Eur Heart J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","article-title":"2024 ESC guidelines for the management of atrial fibrillation developed in collaboration with the European association for cardio-thoracic surgery (EACTS)","volume":"45","author":"Van Gelder","year":"2024","journal-title":"Eur Heart J"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1016\/S0735-1097(01)01635-7","article-title":"Surgical treatment for secundum atrial septal defects in patients >40 years old. 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