{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:07:09Z","timestamp":1787962029681,"version":"build-2784847793"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Arterial hypertension plays a significant role in promoting organ damage and the development of atherosclerosis. The neutrophil\u2013lymphocyte ratio (NLR) is an accessible and cost-effective biomarker that has been strongly associated with adverse outcomes in patients with coronary artery disease and chronic heart failure. The aim of this study was to evaluate the clinical utility of NLR as a surrogate biomarker of subclinical atherosclerotic damage in patients with essential hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From January 2024 to November 2024, we consecutively enrolled 346 patients with essential hypertension. For all patients, we collected medical history, anthropometric data, biochemical analyses, and subclinical organ damage, including 24-h urinary excretion of microalbuminuria, carotid intima\u2013media thickness, and transthoracic echocardiography. We excluded patients with arterial hypertension, coronary artery disease, or cerebrovascular or peripheral artery disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In our study, we found that patients with higher NLR were associated with high blood pressure values, the use of more than three antihypertensive medications, and a higher prevalence of dyslipidemia and obstructive sleep apnea syndrome. Moreover, elevated NLR values correlated with a higher prevalence of subclinical organ damage (left cardiac ventricular mass, carotid atherosclerosis, and increased microalbuminuria).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study shows that in patients with essential hypertension, NLR is significantly correlated with some cardiovascular comorbidities and subclinical organ damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2025.1579930","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:25:26Z","timestamp":1761891926000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Neutrophil\u2013lymphocyte ratio and subclinical atherosclerosis in essential hypertensive patients"],"prefix":"10.3389","volume":"12","author":[{"given":"Luigi","family":"Petramala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Circosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Cremonesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Menichelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Cim\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Servello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Anastasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Letizia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1097\/HJH.0000000000003480","article-title":"2023 ESH guidelines for the management of arterial hypertension the task force for the management of arterial hypertension of the European society of hypertension: endorsed by the International Society of Hypertension (ISH) and the European Renal Association","volume":"41","author":"Mancia","year":"2023","journal-title":"J Hypertens"},{"key":"B2","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1038\/hr.2011.6","article-title":"Are blood pressure and diabetes additive or synergistic risk factors? 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