{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T20:48:32Z","timestamp":1772052512411,"version":"3.50.1"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The 6\u2005min walk test (6MWT) is widely used to evaluate functional exercise capacity, therapeutic effects, and prognosis in patients with cardiopulmonary diseases. However, its application in phase I cardiac rehabilitation (CR) after coronary artery bypass grafting (CABG) remains under explored. This study investigates the physical performance of CABG patients during the early 6MWT and analyzes factors influencing their walking performance during inpatient CR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 360 patients who underwent isolated off-pump coronary artery bypass (OPCAB, <jats:italic>n<\/jats:italic>\u2009=\u2009240) or minimally invasive direct coronary artery bypass (MIDCAB, <jats:italic>n<\/jats:italic>\u2009=\u2009120) surgery. Participants, with a median age of 63 years (range: 36\u201380), comprised 285 males and 75 females. The study was conducted from November 22, 2023, to December 25, 2024. It specifically included patients who completed the 6MWT within 5\u2009\u00b1\u20092 days during phase I CR post-surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median 6\u2005min walk distance (6MWD) was 183\u2009\u00b1\u2009125 meters (33\u2009\u00b1\u200920% of predicted). Notably, the walking distances were significantly shorter in OPCAB patients than MIDCAB patients (175\u2009\u00b1\u2009125 vs. 200\u2009\u00b1\u2009134 meters, <jats:italic>Z<\/jats:italic>\u2009=\u2009\u22123.426, <jats:italic>P<\/jats:italic>\u2009=\u20090.001), in older patients than younger patients (<jats:italic>H<\/jats:italic>\u2009=\u200920.489, <jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.001) and in females than males (150\u2009\u00b1\u200984 vs. 200\u2009\u00b1\u2009100 meters, <jats:italic>Z<\/jats:italic>\u2009=\u2009\u22125.919, <jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.001). Univariate analysis showed 6MWD significantly correlated with height, weight, body mass index (BMI), diastolic blood pressure (DBP) and peripheral oxygen saturation (SpO2) before the test, as well as heart rate (HR), systolic blood pressure (SBP), DBP, SpO2, and respiratory rate (RR) after the test, and the mean values of HR and RR during the test. The stepwise multivariate regression analysis identified that gender, type of surgery, HR and RR at the end of the test, and DBP before the test were independent predictors of the 6MWD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study is the first to describe early 6MWD in CABG patients during phase I CR. The 6MWT is feasible and well-tolerated in adults and older patients shortly after CABG. The findings provide valuable insights into factors affecting walking distance, aiding clinical assessment and informing phase II CR program development post-discharge.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2025.1580442","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T05:38:43Z","timestamp":1753940323000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Physical performance on the early 6-minute walk test in coronary artery bypass grafting patients during inpatient cardiac rehabilitation"],"prefix":"10.3389","volume":"12","author":[{"given":"Yao","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqun","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.3892\/etm.2016.3541","article-title":"Epidemiological aspects of heart diseases","volume":"12","author":"Shi","year":"2016","journal-title":"Exp Ther Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1161\/01.Cir.0000138790.14877.7d","article-title":"ACC\/AHA 2004 guideline update for coronary artery bypass graft surgery: summary article: a report of the American college of cardiology\/American heart association task force on practice guidelines (committee to update the 1999 guidelines for coronary artery bypass graft surgery)","volume":"110","author":"Eagle","year":"2004","journal-title":"Circulation"},{"key":"B3","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1056\/NEJMoa0804626","article-title":"Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease","volume":"360","author":"Serruys","year":"2009","journal-title":"N Engl J Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1177\/2047487313502405","article-title":"The 6-minute walking test and all-cause mortality in patients undergoing a post-cardiac surgery rehabilitation program","volume":"22","author":"La Rovere","year":"2015","journal-title":"Eur J Prev Cardiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1002\/clc.23296","article-title":"Cardiac rehabilitation in older adults: new options","volume":"43","author":"Kumar","year":"2020","journal-title":"Clin Cardiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1753944719870084","DOI":"10.1177\/1753944719870084","article-title":"6-minute Walking test: a useful tool in the management of heart failure patients","volume":"13","author":"Giannitsi","year":"2019","journal-title":"Ther Adv Cardiovasc Dis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1177\/1741826711422991","article-title":"Six-minute walking test but not ejection fraction predicts mortality in elderly patients undergoing cardiac rehabilitation following coronary artery bypass grafting","volume":"19","author":"Cacciatore","year":"2012","journal-title":"Eur J Prev Cardiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1164\/ajrccm.166.1.at1102","article-title":"ATS Statement: guidelines for the six-minute walk tes","volume":"166","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1097\/ccm.0000000000001059","article-title":"Postoperative critical care of the adult cardiac surgical patient. 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