{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:12:20Z","timestamp":1787026340275,"version":"build-2736575974"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Mitochondrial disorders frequently precipitate progressive conduction system degeneration, with complete heart block representing a critical therapeutic challenge in pediatric populations, which ultimately requires permanent pacemaker implantation. However transjugular venous implantation of the Aveir leadless pacemaker in a pediatric patient with mitochondrial disease has not been previously reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>An 8.7-year-old, female patient (weight: 25\u2005kg) with genetically confirmed mitochondrial disease presented with cardiac syncope secondary to the complete atrioventricular block. Comorbidities included insulin-dependent diabetes and pocket infection from a conventional permanent pacemaker implanted four months prior. Given her history of device-related complications and restricted venous access, a retrievable leadless pacemaker (Abbott Aveir) was successfully implanted via the internal jugular vein under fluoroscopic guidance without complication. Stability testing confirmed adequate fixation with pacing threshold of 1.0V@0.2\u2005ms and impedance of 610\u03a9 at one-month follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The Aveir VR leadless pacemaker can be safely implanted via the internal jugular vein approach in pediatric patients with mitochondrial disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fcvm.2025.1593438","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:45:28Z","timestamp":1760100328000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Aveir implantation in an 8.7-year-old, 25-kg pediatric patient with mitochondrial disease via internal jugular 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