{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:21:24Z","timestamp":1785853284635,"version":"3.56.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>While the hybrid intravascular ultrasound-optical coherence tomography (IVUS-OCT) imaging system offers theoretical advantages for enhanced characterization of vascular morphology and histopathology through multimodal integration, its clinical efficacy lacks systematic validation. We conducted a comprehensive comparative analysis of this novel hybrid imaging modality against conventional single-modality OCT and IVUS systems, aiming to establish an evidence-based foundation for its clinical implementation and broader adoption in interventional cardiology practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the clinical advantages of hybrid intravascular ultrasound-optical coherence tomography (IVUS-OCT) system compared with single-modality imaging techniques in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The hybrid IVUS-OCT intracoronary imaging system was employed to evaluate the characteristics of coronary atherosclerotic plaques and the immediate post-stent outcomes and compared against single-modality OCT and IVUS. The post-stent immediate effects were evaluated by the clear stent capture rate (CSCR), identification of incomplete stent apposition, tissue protrusion, and stent edge dissection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>74 patients underwent successful hybrid imaging (82 vessels imaged). Plaque analysis (23 vessels) identified 41 plaques [21 lipid, 20 calcified, 2 thin-cap fibroatheromas (TCFAs)]. OCT alone detected 21 lipid, 16 calcified, 3 possible TCFAs (maximal calcified arc accuracy: 68.75%). IVUS alone detected 15 lipid, 20 calcified, 0 TCFAs (maximal calcified arc accuracy: 85%). For post-stent evaluation (74 vessels), hybrid imaging visualized all stents (CSCR\u2009=\u2009100%), detecting 23 incomplete stent apposition, 10 tissue protrusions, and 10 edge dissections. OCT detected 66 CSCR (89.19%), 23 incomplete stent apposition (100%), 10 tissue protrusions (100%), and 10 edge dissections (100%). IVUS detected 37 CSCR (50%), 8 incomplete stent apposition (34.78%), 2 tissue protrusions (20%), and 7 edge dissections (70%). Hybrid IVUS-OCT and OCT significantly outperformed IVUS in CSCR, tissue protrusion, and incomplete stent apposition detection (<jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The hybrid IVUS-OCT intracoronary imaging system outperforms single-modality IVUS or OCT in evaluating coronary atherosclerotic plaque characteristics and immediate post-stent outcomes.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2025.1595889","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T15:28:11Z","timestamp":1751642891000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Advantages of hybrid intravascular ultrasound-optical coherence tomography system in clinical 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