{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:37:28Z","timestamp":1771511848797,"version":"3.50.1"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Blood donation is a common procedure, yet its acute effects on central and peripheral hemodynamics are not fully understood. This study aimed to systematically quantify immediate cardiovascular changes induced by whole blood donation in healthy adults, with a primary focus on arterial pressure and central hemodynamic parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty healthy volunteers (12 female, 18 male; median age 34 years, IQR 24\u201353) underwent standardized whole blood donation. Non-invasive measurements of central and peripheral hemodynamics were performed immediately before and after donation using the VascAssist 2 device, enabling assessment of brachial and aortic blood pressures, heart rate, augmentation index (AIx), pulse wave velocity (PWV), and left ventricular ejection time (LVET).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Blood donation resulted in a significant reduction in brachial systolic blood pressure (SBP) [pre: 131\u2005mmHg [IQR 121\u2013138] vs. post: 127\u2005mmHg [IQR 116\u2013134]; median change \u22124mmHg, IQR \u221210 to 0; <jats:italic>p<\/jats:italic>\u2009=\u20090.002]. No statistically significant changes were observed in heart rate [pre: 72\u2005bpm [IQR 68\u201380] vs. post: 74\u2005bpm [IQR 64\u201381]; <jats:italic>p<\/jats:italic>\u2009=\u20090.82], diastolic blood pressure (DBP) [pre: 75\u2005mmHg [IQR 68\u201381] vs. post: 74\u2005mmHg [IQR 70\u201385]; <jats:italic>p<\/jats:italic>\u2009=\u20090.66], aortic SBP, or central PWV. Significant reductions were observed in augmentation index [AIx75: pre 1% [IQR \u22129 to 6] vs. post \u22125% [IQR \u221211 to 4]; <jats:italic>p<\/jats:italic>\u2009=\u20090.02] and LVET [pre: 244\u2005ms [IQR 225\u2013257] vs. post: 231\u2005ms [IQR 215\u2013243]; <jats:italic>p<\/jats:italic>\u2009=\u20090.0005]. No statistically significant correlations were identified between these hemodynamic responses and sex, age, body mass index, or hemoglobin concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acute whole blood donation induces a mild but statistically significant decrease in peripheral SBP, accompanied by reductions in AIx and LVET, while central aortic blood pressure and vascular stiffness remain unchanged. These findings indicate that healthy individuals exhibit immediate adaptive mechanisms that preserve central cardiovascular stability in response to mild volume depletion. The results support the overall hemodynamic tolerability of blood donation and provide insight into the transient vascular and cardiac adaptations elicited by acute blood loss.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fcvm.2025.1628366","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T05:28:16Z","timestamp":1758605296000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Changes in central and peripheral hemodynamic parameters during blood donation"],"prefix":"10.3389","volume":"12","author":[{"given":"Babak","family":"Yazdani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6khan","family":"Y\u00fccel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Kayser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behnam","family":"Shaygi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine","family":"Poschauko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard K.","family":"Kr\u00e4mer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Duerschmied","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Hohneck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"B1","volume-title":"Global Status Report on Blood Safety and Availability","year":"2021"},{"key":"B2","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/S0140-6736(24)01550-2","article-title":"The global blood donation index: an imperfect measure of transfusion need","volume":"404","author":"Jacobs","year":"2024","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1001\/jama.299.19.2279","article-title":"Adverse reactions to allogeneic whole blood donation by 16- and 17-year-olds","volume":"299","author":"Eder","year":"2008","journal-title":"JAMA"},{"key":"B4","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1111\/trf.15701","article-title":"Reduced risk of vasovagal reactions in Australian whole blood donors after national implementation of applied muscle tension and water loading","volume":"60","author":"Thijsen","year":"2020","journal-title":"Transfusion"},{"key":"B5","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jsams.2021.10.012","article-title":"Effects of blood withdrawal on cardiac, hemodynamic, and pulmonary responses to a moderate acute workload in healthy middle-aged and older females","volume":"25","author":"Pentz","year":"2022","journal-title":"J Sci Med Sport"},{"key":"B6","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1111\/j.1537-2995.2003.00663.x","article-title":"Cerebral oxygenation and hemodynamics during blood donation studied by near-infrared spectroscopy","volume":"44","author":"Menke","year":"2004","journal-title":"Transfusion"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1016\/j.ijcard.2012.04.155","article-title":"Measurement accuracy of non-invasively obtained central blood pressure by applanation tonometry: a systematic review and meta-analysis","volume":"167","author":"Cheng","year":"2013","journal-title":"Int J Cardiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1038\/ajh.2011.146","article-title":"Quantification of the calibration error in the transfer function-derived central aortic blood pressures","volume":"24","author":"Shih","year":"2011","journal-title":"Am J Hypertens"},{"key":"B9","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1152\/japplphysiol.00405.2017","article-title":"Multiple coupled resonances in the human vascular tree: refining the westerhof model of the arterial system","volume":"124","author":"Schumacher","year":"2018","journal-title":"J Appl Physiol (1985)"},{"key":"B10","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0021-9290(69)90024-4","article-title":"Analog studies of the human systemic arterial tree","volume":"2","author":"Westerhof","year":"1969","journal-title":"J Biomech"},{"key":"B11","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1007\/s00392-017-1080-7","article-title":"Automated oscillometric blood pressure and pulse-wave acquisition for evaluation of vascular stiffness in atherosclerosis","volume":"106","author":"Massmann","year":"2017","journal-title":"Clin Res Cardiol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1093\/ajh\/hpaa174","article-title":"Automated noninvasive central blood pressure measurements by oscillometric radial pulse wave analysis: results of the MEASURE-cBP validation studies","volume":"34","author":"Trinkmann","year":"2021","journal-title":"Am J Hypertens"},{"key":"B13","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1093\/ajh\/hpae156","article-title":"Central vs. brachial blood pressure and pulse pressure amplification for mortality risk prediction in patients undergoing coronary angiography","volume":"38","author":"Daschner","year":"2025","journal-title":"Am J Hypertens"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1053\/j.jvca.2025.04.002","article-title":"Prognostic value of noninvasive central blood pressure and arterial stiffness in hemodynamic shock","volume":"39","author":"Markakis","year":"2025","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"B15","first-page":"175","article-title":"Noninvasive central hemodynamic monitoring in the primary care setting: improving prevention and management of cardiovascular diseases","volume":"9","author":"Grogan","year":"2023","journal-title":"J Clin Transl Res"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e2350","DOI":"10.6061\/clinics\/2021\/e2350","article-title":"Predictors and reference equations for augmentation index, an arterial stiffness marker, in healthy children and adolescents","volume":"76","author":"Santos","year":"2021","journal-title":"Clinics (Sao Paulo)"},{"key":"B17","doi-asserted-by":"publisher","first-page":"R1540","DOI":"10.1152\/ajpregu.00368.2015","article-title":"Impact of blood pressure perturbations on arterial stiffness","volume":"309","author":"Lim","year":"2015","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1186\/s12887-025-05731-4","article-title":"The near-infrared spectroscopy to evaluate neonatal improvement after transfusion: a systematic review and meta-analysis","volume":"25","author":"Zheng","year":"2025","journal-title":"BMC Pediatr"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1616125","DOI":"10.3389\/fphys.2025.1616125","article-title":"Continuous wavelet based transfer function analysis of cerebral autoregulation dynamics for neuromonitoring using near-infrared spectroscopy","volume":"16","author":"Thudium","year":"2025","journal-title":"Front Physiol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1111\/trf.13975","article-title":"Donating blood on a regular basis appears to reduce blood pressure, but appearances can be deceiving","volume":"57","author":"France","year":"2017","journal-title":"Transfusion"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.3390\/jcm14072230","article-title":"Association between arterial stiffness, high blood pressure, and hypertensive phenotypes: insights from the PAMELA study","volume":"14","author":"Quarti-Trevano","year":"2025","journal-title":"J Clin Med"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1101\/2025.06.26.25330379","article-title":"Central and brachial pressures: effects on arterial stiffness in older adults","author":"Gupta","year":"2025","journal-title":"medRxiv"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1113972","DOI":"10.3389\/fphys.2023.1113972","article-title":"Aortic systolic and pulse pressure invasively and non-invasively obtained: comparative analysis of recording techniques, arterial sites of measurement, waveform analysis algorithms and calibration methods","volume":"14","author":"Bia","year":"2023","journal-title":"Front Physiol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12245-023-00563-4","article-title":"Volume replacement in the resuscitation of trauma patients with acute hemorrhage: an umbrella review","volume":"16","author":"Gianola","year":"2023","journal-title":"Int J Emerg Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1097\/00000658-196310000-00016","article-title":"Transcapillary refilling after hemorrhage in normal man: basal rates and volumes; effect of norepinephrine","volume":"158","author":"Lister","year":"1963","journal-title":"Ann Surg"},{"key":"B26","doi-asserted-by":"publisher","first-page":"R425","DOI":"10.1152\/ajpregu.00011.2005","article-title":"Plasma protein and blood volume restitution after hemorrhage in conscious pregnant and ovarian steroid-replaced rats","volume":"290","author":"Blair","year":"2006","journal-title":"Am J Physiol Regul Integr Compar Physiol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.autneu.2010.11.008","article-title":"The effects of acute blood loss on blood pressure recovery from the valsalva maneuver","volume":"160","author":"Paprika","year":"2011","journal-title":"Auton Neurosci"},{"key":"B28","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1097\/HJH.0000000000001583","article-title":"Myocardial preload alters central pressure augmentation through changes in the forward wave","volume":"36","author":"van de Velde","year":"2018","journal-title":"J Hypertens"}],"container-title":["Frontiers in Cardiovascular Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1628366\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T05:28:18Z","timestamp":1758605298000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fcvm.2025.1628366\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,23]]},"references-count":28,"alternative-id":["10.3389\/fcvm.2025.1628366"],"URL":"https:\/\/doi.org\/10.3389\/fcvm.2025.1628366","relation":{},"ISSN":["2297-055X"],"issn-type":[{"value":"2297-055X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,23]]},"article-number":"1628366"}}