{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:12:20Z","timestamp":1787026340281,"version":"build-2736575974"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Cardiovasc. Med."],"abstract":"<jats:p>Selective adrenal artery embolization (SAAE) has emerged as a promising minimally invasive alternative to traditional therapies for primary aldosteronism (PA). However, incomplete ablation of aldosterone-producing adenomas (APA) tissue remains a key limitation. To address this challenge, we propose a novel hybrid approach integrating SAAE with selective adrenal venous embolization (SAVE), designed to optimize the therapeutic efficacy of APA. We report a 37-year-old man with confirmed unilateral PA. Left adrenal APA was diagnosed through computerized tomography and adrenal venous sampling. The patient underwent combined selective adrenal artery and venous embolization (SAAE-SAVE) for left-sided APA. Trans-catheter embolization of the dominant left adrenal artery and primary draining vein was performed using 2\u2005ml anhydrous ethanol. This SAAE-SAVE protocol successfully normalized serum hypokalemia levels and achieved sustained blood pressure control at 1-month follow-up. SAAE-SAVE represents a transformative therapeutic alternative for APA treatment, and further research is needed to validate its safety and efficacy.<\/jats:p>","DOI":"10.3389\/fcvm.2025.1628754","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T05:33:29Z","timestamp":1756791209000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: A hybrid approach of selective adrenal artery and venous embolization for the treatment of unilateral aldosterone-producing adenoma"],"prefix":"10.3389","volume":"12","author":[{"given":"Changqiang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1016\/j.jacc.2017.01.052","article-title":"Prevalence and clinical manifestations of primary aldosteronism encountered in primary care practice","volume":"69","author":"Monticone","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1161\/HYPERTENSIONAHA.106.086116","article-title":"Is there an unrecognized epidemic of primary aldosteronism? 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