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Hypokalemia (3.5\u20132.0\u2005mmol\/L) dose-dependently triggered abnormal arrhythmias and increased the incidence of arrhythmias, while SAL (5\u2005ug\/ml) improved this situation. Transcriptomics revealed that hypokalemia upregulated Mt-nd6 and disrupted the inflammatory\/immune pathways, while SAL reversed these changes and activated PPAR-related genes. SAL improves the electrophysiological abnormalities caused by hypokalemia by regulating inflammation, immunity and energy metabolism, and has the potential to treat related arrhythmias.<\/jats:p>","DOI":"10.3389\/fcvm.2025.1628940","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T05:31:43Z","timestamp":1754976703000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Salidroside ameliorates abnormalities in electrophysiological indices induced by perfusion of the heart with low-potassium 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